DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and erap1a

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	956	Identity:	287/956 - (30%)
Similarity:	455/956 - (47%)	Gaps:	128/956 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 LKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALA 352
            ::|.|..:|.||.|||.|::.:....|.:.|:||  |.:.|  ..|:|...|:.:|     :||.
Zfish    42 MRLPEIVKPQHYDLLIHPNLTSLTFTGEVQIQIE--VKQDT--RAIILHSKNLQVS-----KALL 97

  Fly   353 DGASNASEEQDL---DFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTS 414
            .|:......|||   :|:::  |..|.|    |:....|....| :.|:|.:.::|:..|.||..
Zfish    98 LGSRQHHHHQDLQISEFEAN--EQIALF----SEGFTFEKGSHV-VHLEFYANLSDSFHGFYKGQ 155

  Fly   415 YTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRR 479
            ||. ::.....:.||||.|..||.||||||.|..||||:|.:.|..: .:::|||||..:.....
Zfish   156 YTT-NSGEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRESR-HISISNMPKLRTVELAD 218

  Fly   480 GFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLP 544
            |.:.|.|:|..||.|||||||:   .|....|:.|.....:.::|.|:.:....||.......|.
Zfish   219 GILEDQFDTMVKMSTYLVAFII---CDFHSISKKSQHGVEISVYTVPEKISQAEYALDTAVTMLD 280

  Fly   545 YYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAH 609
            :|:::|.|...|||.||.::|||...|||||||.|:|:|.||.  |.:.:|||:.:.:.. :|||
Zfish   281 FYDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTYRESGLLF--DPEKSSSSDKLGITK-VIAH 342

  Fly   610 ELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSH 674
            ||||||||||||.:||:||||.||||.:|.|.::...|||.|..|......| .::..|:.::||
Zfish   343 ELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPELQVNDYFLEKCF-TALSVDSLSSSH 406

  Fly   675 AISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAML 739
            .:|..|.:..::..:||.:||.||..:|.||...:....|:....:.|||.:|.|.....||..|
Zfish   407 PVSTPVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESL 471

  Fly   740 TR----HGHEQGTLPKD--------------------LSVKQIMDSWITQPGYPVVNVERRGADL 780
            |.    .|.:.|.|..|                    :.|..|||:|..|.|:|::.||.:|.::
Zfish   472 TNICTSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITVEVKGQEV 536

  Fly   781 VLRQERYLLPSKNTADQS-TWFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDN 844
            .|:|||:|..::::...| .|.:|:|:.|    .|.|....::...:.:
Zfish   537 TLKQERFLKGAESSNSSSFLWQVPLTYIT----SGSNAVQRFLLKTERD---------------- 581

  Fly   845 VIYL---------NLNRQGYYRVNYDMTSW----LALKKNFSTLPRITRAQLLDDALHLSQAEYL 896
            |.||         |::.:|||.|:|:...|    ..|:.|.:......||.|:.|...|...|.:
Zfish   582 VFYLPEKVEWIKFNVDLRGYYIVHYESGGWDCLIKQLRMNHTVFSSNDRASLIHDIFQLVSIEKV 646

  Fly   897 TYDIPLTFLMELFDAVDDELLWIAAKPGLNYLI--YNL--KR--EPAYETFRAFMKFIVRPAFDH 955
            ..|..|.  :.|:.:.:.|::.:.  .|.:.|:  |.|  ||  :......::.:..:.:|..|.
Zfish   647 PLDKALN--LSLYLSKESEIMPVT--QGFSELVPLYKLMEKRDMQELENQLKSHLVKLFQPLIDR 707

  Fly   956 YGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSL 1020
            ....:..:.|...|::..|:  |||...|..|...|...|.:|........:..::..|:|
Zfish   708 QSWSDNGSVSERMLRNYLLL--FACVRRYPSCVSTATQLFHKWKESDGKMWLPTDVSLVVY---- 766

  Fly  1021 AEGSSPE--WYFAYKQYKTTTSASEKEEILTSLGCT----TKPWLLSKYLNMTINPTSGILKQDG 1079
            .||:..:  |.|..::||.:.|.|||..|..:|..:    ...|||.:.....|..|     ||.
Zfish   767 TEGARTDDGWDFLLEKYKRSVSPSEKWMIKAALSYSPLAHKLQWLLERSSEGEIMKT-----QDL 826

  Fly  1080 ALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLD---- 1140
            .....:|:.|..|.::|:|||:.|..::|:.:..|.|.:|.::..:|    ..|...::||
Zfish   827 PSMLISVSKNPKGFKLAWDFLKSNWGKLVKKFDLGSSAISRVVVGVT----DQYSTKEMLDEVEL 887

  Fly  1141 ---LAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSLKNFLE 1183
               ..|..:..||.:::.    |||::..||.|...:...||.:|:
Zfish   888 FFGSLAQDQGSGLRSIQQ----ALEKIQQNILWMDRNVPLLKAWLD 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	153/404 (38%)
		M1_APN_2	297..769	CDD:189008	178/498 (36%)
		ERAP1_C	846..1138	CDD:288671	75/316 (24%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	155/411 (38%)
		M1_APN_2	52..525	CDD:189008	178/497 (36%)
		ERAP1_C	592..909	CDD:288671	80/339 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850