DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and trhde.2

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	936	Identity:	282/936 - (30%)
Similarity:	462/936 - (49%)	Gaps:	84/936 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 RPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRA 350
            |.|:|....||.||.|.:...:.....:|.:.||.|    .|.|.:.|||....:.:..|.|
Zfish   106 RHLRLPATLRPRHYDLRLTVHMENFSFSGEVNIEFE----CVNSTKLIVLHSDRLELDKVLV--- 163

  Fly   351 LADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVL-LSLDFVSQVTDTLQGIYKTS 414
            .:|.....:......|   :.:....:||.|.:.:   ..||.. :::.|.:.:...|.|.:::|
Zfish   164 FSDSKKAGAMRIQRRF---HYQPKQVYVIALHREM---KPLRTYKINITFTAHIEHELLGFFRSS 222

  Fly   415 Y-TNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFR 478
            | .|.:.:   ::..|||||..||:||||||.|..||.|.:|:.....:: :|||||...:....
Zfish   223 YMLNGERR---FLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQ-SLSNMPVEATTSDE 283

  Fly   479 RGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRK 541
            .|::.:.|..||:|.||.:|:.|.|.. .:.|..|:|:.  :.::.||..:  |...||.::.::
Zfish   284 DGWVTNHFSRTPRMSTYYLAWAVCNFT-YKEAVADNGVL--IRLYARPDAIQSGSGDYALRITKR 345

  Fly   542 FLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGI 606
            .|.:|:|:|.:|..|||:||::||...:||||||||..|.:..:|:..|:   ||..:...:..:
Zfish   346 LLQFYQDYFKVKYSLPKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDV---SSFSYQMELTMV 407

  Fly   607 IAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLE--FKESMEHDA 669
            :.||:.|||||:||||.||:|:|||||||.|..|...:...|:: :|:....|.  ..|.|..|.
Zfish   408 VVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKW-NMEKQRFLTDVLHEVMLLDG 471

  Fly   670 DNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDD 734
            ..:||.||..|....|:.|:||.|:|.||..|:|||.:::|...|:.|..|.|....|||..|||
Zfish   472 LASSHPISQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDD 536

  Fly   735 LWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGA---DLVLRQERYLLPSK---- 792
            ||..|:.....:|   ||:::.|:||.|..|.|||||.:.:..:   .:.:.||.::..:.
Zfish   537 LWNKLSEAMQREG---KDINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQ 598

  Fly   793 -----NTADQSTWFIPITFETDELRKGDNIPTH---WMRSEDEEELIVGNVFAHSSNSDNVIYLN 849
                 |.:.|  |.||:|.   .:....:|.|.   |:.::.|... ||:|.     .:..:..|
Zfish   599 NPELFNKSFQ--WQIPLTL---AVGNASHISTETIIWVTNKSEAHR-VGHVV-----GETWLLGN 652

  Fly   850 LNRQGYYRVNYDMTSWLALKKNFSTLPRI----TRAQLLDDALHLSQAEYLTYDIPLTFLMELFD 910
            :|:.||:|||||:.:|..|.:..:..|.|    .||.|:||..:|::|.||..::||..:..|
Zfish   653 INQTGYFRVNYDLHNWKLLIQQLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYL-- 715

  Fly   911 AVDDELL-WIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYG--LHEPDNESHLQLKHR 972
            :.:.|.| |.||...|..|...|.|...:..|..::...|.|.:...|  ...||.    .|.|.
Zfish   716 SQETEFLPWHAASRALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDG----SLMHS 776

  Fly   973 AL--------VAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWY 1029
            |.        |...||.|....|.::|.....:|:...||. |.||::.::|||.::......|.
Zfish   777 AYQTEELQREVIMLACSFGNKHCHRQAVSLISDWISSNKNR-IPPNVRDIVYCTGVSLMDEDVWE 840

  Fly  1030 FAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGIL-KQDGALAFRAVASNAIGH 1093
            |.:.::.::|:.|||:.:|.:|.|:...:||::.||:::  ||.:: .||.......||.|.:|.
Zfish   841 FIWMKFHSSTAVSEKKVLLEALTCSDNIFLLNRLLNLSL--TSDLVPDQDVIDVIIHVARNPLGR 903

  Fly  1094 EIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIE 1158
            .:|:.:.:.....:...||:.....|::|..:|.::|.:...::|.:...|.......|...|:|
Zfish   904 HLAWRYFREKWDILNSRYGEALFMNSKLISGVTEFLNTEAELNELKEFILTSGGESAPAFARAVE 968

  Fly  1159 LALEQVNNNIYWRSHSYHSLKNFLEG 1184
            :....|..:|.::...|..|:...:|
Zfish   969 IVQANVKWHILFQEQFYQWLRKAPDG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	134/407 (33%)
		M1_APN_2	297..769	CDD:189008	162/477 (34%)
		ERAP1_C	846..1138	CDD:288671	86/307 (28%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	136/414 (33%)
		M1_APN_2	118..568	CDD:189008	162/476 (34%)
		ERAP1_C	649..968	CDD:288671	90/327 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040