DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	845	Identity:	262/845 - (31%)
Similarity:	426/845 - (50%)	Gaps:	78/845 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 EDNATF-VINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVD 435
            :|...| ||.|.:.|.|...  ..|..:|..::.|.|.|.|::.|.  :...|:.:.:||..|..
Zfish   151 QDQTEFMVIQLRENLQVGKS--YWLYTEFQGELADDLGGFYRSEYV--ENGVEKVVATTQMQPTA 211

  Fly   436 ARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRF---RRGFIRDDFETTPKMPTYLV 497
            ||.||||||.|.|||.|.::::.| ...:||:|..::|:...   .:..::..||.|.||.|||:
Zfish   212 ARTAFPCFDEPSMKAVFHLTLIHP-PGTVALANGMETGTENITIENQQVLQTRFEPTEKMSTYLL 275

  Fly   498 AFIVSNM--VDSRLASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPK 558
            ||::|..  :.|.|.:...    .|.||.|.:.:  |...||..:....|.|.|.::.....|.|
Zfish   276 AFVISEFPSIQSPLGANKI----LVRIWGRREAIENGEGDYALNVTFPVLKYLESYYNTTYPLSK 336

  Fly   559 IDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPK 623
            .|.:::|||...|||||||:|:|::.|.....:   ||.|..:.|..:|:|||||.|||||||.:
Zfish   337 SDQIALPDFSAGAMENWGLVTYRETFLFYEPKV---SSHEDKEGVITVISHELAHMWFGNLVTMR 398

  Fly   624 WWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISF---DVRSTND 685
            ||:||||.||||.|:||.|.::|.|.:...:.:.:.:...:...||..:||.:|.   .|.:...
Zfish   399 WWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALVSSHPLSSREDAVNTPQQ 463

  Fly   686 VRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLP 750
            :..:||.::||||..:||||:..:.:..|.....:.|::.||.|....|||..|.......|.:.
Zfish   464 IEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVYTDLWKKLQEVADSDGNVH 528

  Fly   751 KDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQST-----WFIPITFETDE 810
            ...|:::||:.||.|.|:|||.::.....  :.|:.:|:..:...::.:     ||:|||:
Zfish   529 LPASIEEIMNRWILQAGFPVVTIDTHTGS--ISQQHFLIDPEAVVNKPSDYNYEWFVPITW---- 587

  Fly   811 LRKGDNIPTHWMRSEDEE-ELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWLALKKNFST 874
            ::.|.|:..||:.::... ||:        ....|.|..|||..||||||||..:|..|.|..::
Zfish   588 MKNGRNMGQHWLLNKSTSYELM--------KTETNWILANLNVTGYYRVNYDSQNWERLIKQLTS 644

  Fly   875 ----LPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDE---LLWIAAKPGLNYLIYNL 932
                :|.:.|.|::|||..|::|:.|.    :|..:.....:.:|   :.|.:|...|.|.....
Zfish   645 DHQAIPVLNRGQIIDDAFTLARAKILN----ITMALRTTQYLSNEKEYIPWESAIRNLEYFFLMF 705

  Fly   933 KREPAYETFRAFMKFIVRPAFDHYGL------HEPDNESHLQLKHRALVAYFACKFNYDRCTQKA 991
            .|........|:::..|.|.|.::.:      .:|..  |:...::......|||.....|::..
Zfish   706 DRTEVRGPLEAYLRRKVEPLFHYFKVITSNWTRKPTR--HMDQYNQLNAITMACKTRVKACSELT 768

  Fly   992 QMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTK 1056
            .|.:|:||:||..||:..:||:|:||.::|.|...||.|.:..:|.:|.|:|.|:::..|.||.:
Zfish   769 SMWYRQWMKDPNVNPVPSDLKTVVYCNAIAAGGVEEWDFGWAMFKNSTVAAEAEKLMYGLSCTKE 833

  Fly  1057 PWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEM 1121
            ||||::||:..|:|.. |.|||.......:|||.||..:|:||.:...:.:.       :....:
Zfish   834 PWLLNRYLHYAIDPNL-IRKQDVTYPIVYIASNVIGQPLAWDFFRAKWQLMT-------TEFRVL 890

  Fly  1122 IKSLTIYMNKDYHKHQLL----DLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSLKNFL 1182
            |..:....:.::...||.    ::|.:...||.||:|.||    ||...|:.|.|.:...:.::|
Zfish   891 ILGIVKTFSTEFQLQQLQRFQEEVAESGVSLGTHAIEQAI----EQTKANVKWVSENKVQVMDWL 951

Fly 1183 1182
Zfish 952 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	118/336 (35%)
		M1_APN_2	297..769	CDD:189008	141/407 (35%)
		ERAP1_C	846..1138	CDD:288671	88/304 (29%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	141/407 (35%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	100/337 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920