DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	1083	Identity:	296/1083 - (27%)
Similarity:	487/1083 - (44%)	Gaps:	189/1083 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 PP--SGVYVSKACLIIAAFITVLALLFTIAITYFVTRQGLNPKEVTPPSCITADHPDVNATPIQT 210
            ||  ||:|||:...::.|.:|.:.||   |:.......|         ||......::::..::.
  Rat     3 PPFSSGIYVSRGVALLLAGLTAVLLL---ALVVLAALYG---------SCAHVQSSELDSHLVKD 55

  Fly   211 AGWVSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGE 275
            ...    |||..|..|     .|||.:..||.|:
  Rat    56 TSL----SPPGGQEWT-----QPTPAHESTVGTS------------------------------- 80

  Fly   276 VEDNTTKPINRP---LKLYEGWRPLHYSLLIEPSV-ATSISNGSLT------IEIERDVS----- 325
               ...:|.:.|   |:|.....||||.|.:.|.: ..::|..|||      |.:...|:
  Rat    81 ---QDWRPPSGPWDHLRLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLL 142

  Fly   326 ---------KVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINL 381
                     :|..|.|:..|..|.::..|.:            |......|..|      .|::|
  Rat   143 LHSFFLNYKQVEVWGPLAPDTRNATVGRVPL------------ENVWFALDMQY------VVLDL 189

  Fly   382 SKTLAVETQLRVLLSLDFVSQV-TDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDR 445
            .::|...:...  |:.||..|| .:..:|::...||:.|....  :|:||..|..||..|||||.
  Rat   190 GQSLDPGSSYE--LNFDFSGQVLQEGSEGLFLNLYTDEDQLRA--LIATQMEPTFARHVFPCFDE 250

  Fly   446 PDMKANFSISIVRPMQFKMALSNMPK---------SGSRRFRRGFIRDDFETTPKMPTYLVAFIV 501
            |.:||.|:|:|:....: :||||||:         :|||     :....|.|||:|||||||.::
  Rat   251 PALKATFNITIIHHPGY-VALSNMPQLGQSHRIDVNGSR-----WTVTSFHTTPRMPTYLVALVI 309

  Fly   502 SNMVDSRLASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSV 564
            .:.  ..::..:.|  ..:.:|.|...:  |...:|.........:.||.|.|...|||.|::::
  Rat   310 CDF--DYVSRTERG--KEIRVWARKDDIADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIAL 370

  Fly   565 PDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLW 629
            |.|...|||||||:.| |::||:..|..|   .|...::..|::||:.|||||||||..||:::|
  Rat   371 PTFVNGAMENWGLMIF-DASLLLELDDDL---PEKRAMILSILSHEVGHQWFGNLVTMSWWNNIW 431

  Fly   630 LKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRS---TNDVRRIFD 691
            |.||||.|.......:.:|:........:....:.:|.|....|.|:|..|.:   |.::.|:||
  Rat   432 LNEGFASYFEVGLTNYFYPKVPRNMIFFLTVLHDILEDDHSLESRAVSTPVENFTETREINRLFD 496

  Fly   692 PISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVK 756
            ..:|.||..:..||...:....|.:|.:..|:.|:|.|.::||||..:.....||..:....:||
  Rat   497 IYTYKKGACMAWMLAGFLSQHLFINALKSYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVK 561

  Fly   757 QIMDSWITQPGYPVVNVERRGADLVLRQERYLL---PSKNTADQSTWFIPITFETDELRKGDNIP 818
            :|||||..|.|:||:.:  ..:..|::||.:.|   .::.....:||.:||.:    ::.|...|
  Rat   562 RIMDSWTHQSGFPVITL--NASTGVVKQEPFYLERVENQTLLSHNTWIVPIFW----MKNGITQP 620

  Fly   819 THWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTLPRIT 879
            ..|:   |:..:|...:....|:||.|| ||.|..||||||||...|    ..|:|:...:|.|.
  Rat   621 LVWL---DKSSMIFPGMKLSDSDSDWVI-LNFNVTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIN 681

  Fly   880 RAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL-WIAAKPGL--NYLIYNLKREPAYETF 941
            |.||:.||..||:..|:..:..|.  :..:.|.:||:| |......|  ..::|::|....|...
  Rat   682 RLQLVSDAFALSKNNYIEIETALD--LTKYIAKEDEILVWFEVLVNLINREVVYDVKNYYLYPLL 744

  Fly   942 RAFMKFIVRPAFDHYGLHEPDNESHLQ---LKHRALVAYF--ACKFNYDRCTQKAQMKFREWMRD 1001
            :.:....:...:..|.....:|.:.||   |....|..:|  ||....:.|.|.::..||:||..
  Rat   745 KKYFLKRLNSIWTIYSAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMAH 809

  Fly  1002 PKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEE---ILTSLGCTTKPWLLSKY 1063
            |: ..|.|.::.|:.|.::|.||:.:|.|.:..|...|  .|:|:   ::.::||:..|..|:::
  Rat   810 PE-TAIPPQIEKVVLCNAIALGSNKDWDFLFNLYINKT--EEQEDLFHLVHAMGCSKDPRTLNRF 871

  Fly  1064 L--NMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVE----------YYGDGFS 1116
            :  ::|:.|:    :.:.......||.:.:|..:|.|||..|...:.|          |:...::
  Rat   872 MEYDITVFPS----RFNETNLIEVVAESEVGRYVAKDFLINNWVAVYESPSLSPLLQQYFVSVWT 932

  Fly  1117 TLSEMIKSLTIYMNKD-YHKHQLLDLAATCRKLGLHAVESAIE 1158
            |::|   ..::::.:| .|:.....:||..:    |.|..|.|
  Rat   933 TIAE---HSSVHLREDCQHRSAGYGVAAVPQ----HCVGGAPE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	132/437 (30%)
		M1_APN_2	297..769	CDD:189008	156/507 (31%)
		ERAP1_C	846..1138	CDD:288671	84/319 (26%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	154/502 (31%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	79/281 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850