DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and CG11951

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	317/974 - (32%)
Similarity:	491/974 - (50%)	Gaps:	128/974 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 EDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSIS-------NGSLTIEIERDVSKVTSWEPIV 334
            |.:|......|..|    ||..|.:    .:.|.:.       ||::.|:||           ::
  Fly    18 EGSTYDHFRLPTAL----RPQSYDV----RILTQLENPDDFHFNGTVKIQIE-----------VL 63

  Fly   335 LDVHNVSISNVRVIRALADGASNASEEQDLDFD------SDYGEDNAT---------------FV 378
            .:.||:::                 ..:||..|      |..|.:..|               ::
  Fly    64 QNTHNITL-----------------HSKDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYI 111

  Fly   379 INLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCF 443
            :|..|.|.......  |||.|.:::.|.|.|.|::||.|.......|:..|||.|..||.|||||
  Fly   112 LNTCKELLAGQFYE--LSLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCF 174

  Fly   444 DRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRR--GFIRDDFETTPKMPTYLVAFIVSNMVD 506
            |.|..||:|:|::....:: ..|||||.:.:|....  .::...||.:..|.|||||:.: |...
  Fly   175 DEPGYKASFAITLGYHKKY-TGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSL-NDFS 237

  Fly   507 SRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAA 571
            .:.::..:|...|.  |.||..:....||.::..|.|.|||:.||||..|||:|.::||||...|
  Fly   238 HKPSTLPNGTLFRT--WARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGA 300

  Fly   572 MENWGLITFRDSALLV-PEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFA 635
            ||||||:||.:|.||. ||    .||.|..|..|.|:||||||||||||||.|||.||||.||||
  Fly   301 MENWGLVTFAESTLLYSPE----YSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFA 361

  Fly   636 CYMSYKALEHAHPEF-----QSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISY 695
            .|::...:|..||::     :||..|..:..|:|:|     :||.||..:..|:.:...||.|||
  Fly   362 TYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLE-----SSHPISRPIEMTSQISESFDEISY 421

  Fly   696 SKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMD 760
            .||:.::||::..:|:.|||:..:..|:|:.|.|.::|:||..||:..|:.|:||||.::|.|||
  Fly   422 QKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMD 486

  Fly   761 SWITQPGYPVVNVER----RGADLVLRQERYLLPSKNT----ADQSTWFIPITFETDELRKGDN- 816
            ||..|.||||:||.|    |.|.  |.||||||   ||    |.:..|::|:::...|.:..:|
  Fly   487 SWTLQTGYPVINVTRDYTSRTAK--LSQERYLL---NTDVSRAHKGCWWVPLSYTNQEEKDFNNT 546

  Fly   817 IPTHWMRSEDEEELIVGNVFAHS-SNSDNVIYLNLNRQGYYRVNYDMTSWLAL-----KKNFSTL 875
            .|..||...:..|.:...:  |. ...|..:..|......|:||||..:|..|     .:::.::
  Fly   547 APKEWMECTETGESVPKTI--HDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSI 609

  Fly   876 PRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL-WIAAKPGLNYLIYNLKREPAYE 939
            ..:.||||:||.|:.:......|:|.|..:..|  ..:.||| |.:|...|.::...|::.|.:.
  Fly   610 HVVNRAQLIDDVLYFAWTGEQDYEIALQVISYL--ERERELLPWKSAFDNLQFVSGILRQTPNFR 672

  Fly   940 TFRAFMKFIVRPAFDHY-GLHEPDNESHLQLKH--RALVAYFACKFNYDRCTQKAQMKFREWMRD 1001
            .|:.|.:.::.|.::|. |:::.......|.|.  :|:||.:||.|....|..:|...:|.| |.
  Fly   673 FFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSW-RS 736

  Fly  1002 PKN----NPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSK 1062
            ..|    ||:...::.|:|||::..|...:|.|.:.:|:....|:||:.||.||||:.:.|:|.:
  Fly   737 EANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQR 801

  Fly  1063 YLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLT- 1126
            ||....:....|.|||....|:|:|.:.:|..:|..:|..|:..|.::|.....::||::..|:
  Fly   802 YLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSE 866

  Fly  1127 -IYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSLKNFLEGIVSEF 1189
             |:..:||  .:.::..|: .|..|..:|..|..:||.:..|:.|:..:|   :.|...|...|
  Fly   867 QIFTQRDY--DEFMNFMAS-SKDQLKDIEQTISQSLETMLINVQWKERNY---ERFTRAISKHF 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	152/437 (35%)
		M1_APN_2	297..769	CDD:189008	182/507 (36%)
		ERAP1_C	846..1138	CDD:288671	88/306 (29%)
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	180/501 (36%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	95/333 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920