DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and CG14516

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	1028	Identity:	343/1028 - (33%)
Similarity:	515/1028 - (50%)	Gaps:	133/1028 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PMASPTPTNTPTVT----------TTLAMPAS---SEKPEIRMVDPKVGDIPVVEPAAGE----- 275
            ||.:.|||.|.|.:          ||..:.||   .....:..:.........:||.:.|
  Fly    27 PMNAATPTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCT 91

  Fly   276 ---------VEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSIS-NGSLTIEIE--RDVSKVT 328
                     ..|:|.| .:|.::|....|||.|::.|||.::.:.: .||:.|.|.  .|...:|
  Fly    92 SYHLRRLKAGHDDTPK-YDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNIT 155

  Fly   329 SWEPIVLDVH----NVSISNVRVIRALADGASNASEEQD-LDFDSDY--GEDNATFVINLSKTLA 386
                    :|    |:|.|:..|.|.    .:|...|.| |.....|  |. ...|||.|...|.
  Fly   156 --------MHAEELNISRSDASVHRV----QNNGEPEGDGLRIHKQYLVGA-KQFFVIELYDKLL 207

  Fly   387 VETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNE-EWMISTQFSPVDARRAFPCFDRPDMKA 450
            .:.:..|.|..|.:  :.|.|||.|::||   :..|| .|:.||||...||||||||||.|.:||
  Fly   208 KDVEYVVHLRFDGI--IEDYLQGFYRSSY---EVHNETRWVASTQFQATDARRAFPCFDEPALKA 267

  Fly   451 NFSISIVRPMQFKMALSNMP--KSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQD 513
            ||::.|.||... ..:||||  .|........::.|.|..:..|.|||||:.:|:....     .
  Fly   268 NFTLHIARPRNM-TTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHI-----S 326

  Fly   514 SGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLI 578
            ||   ...:|.|...:....||..:..:.|.:.:|||.:...|||||::::|:|...||||||||
  Fly   327 SG---NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLI 388

  Fly   579 TFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKAL 643
            |||::|:|....:..|::.   |.||.::.||||||||||||||.||.|:||.||||.||.|...
  Fly   389 TFRETAMLYDPGVATANNK---QRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTA 450

  Fly   644 EHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSI 708
            :...||::.:|...:.|.:...:.||.:|||.||.:|.:..::..|||.|||:||:.::||:...
  Fly   451 DAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHF 515

  Fly   709 VGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNV 773
            :.:..||......|::.||.:..:||||..||......|.|....|||:|||:|..|.|||||.|
  Fly   516 LTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKV 580

  Fly   774 ERR-GADLV-LRQERYLLPSKNTADQS-TWFIPITFETD-ELRKGDNIPTHWM-RSE----DEEE 829
            .|. .:|:: |.|.|::..:....|:| .|:|||||.|| ||...:..||.|| |::    :..|
  Fly   581 SRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRE 645

  Fly   830 LIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWLALKK------NFSTLPRITRAQLLDDAL 888
            |.:...|          ..|:.:.||||||||:.:|:|:.:      ||..:....||||:||.:
  Fly   646 LSLAKWF----------IFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVM 700

  Fly   889 HLSQAEYLTYDIPLTFLMELFDAVDDEL---LWIAAKPGLNYLIYNLKREPAYETFRAFMKFIVR 950
            :|::..||:|:.    .|.|...:..||   .|.||.....::.........|:..:.::...::
  Fly   701 NLARGSYLSYET----AMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLK 761

  Fly   951 PAFDHYGLHEPDNESH---LQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDP---KNNPIKP 1009
            ..:|..|..:..:||.   ::|| ||.:...||...:..|..:|...|:.||:.|   .||||.|
  Fly   762 KVYDQVGFKDSQDESEDILVKLK-RADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVP 825

  Fly  1010 NLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSG- 1073
            ||:.|:||:::..|:..||.||::::..|....||:.:|.:|||:.:||||.::|...|   ||
  Fly   826 NLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGI---SGQ 887

  Fly  1074 -ILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQ 1137
             |.|||....|.||::..:|..||||||:.|.:||..|.|...|::..:.|..|...|.   |.|
  Fly   888 HIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKFATKGFNS---KFQ 949

  Fly  1138 LLDLAATCRKLGLHAVESA-------IELALEQVNNNIYWRSHSYHSLKNFLE 1183
            |.:..        :.|:.|       ::..:|.:..::.|.:.:|.|:..:||
  Fly   950 LGEFE--------NFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWLE 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	156/414 (38%)
		M1_APN_2	297..769	CDD:189008	181/484 (37%)
		ERAP1_C	846..1138	CDD:288671	101/308 (33%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	158/421 (38%)
		M1_APN_2	121..576	CDD:189008	181/484 (37%)
		ERAP1_C	652..974	CDD:288671	106/350 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462114
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850