DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and CG31233

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	980	Identity:	261/980 - (26%)
Similarity:	438/980 - (44%)	Gaps:	133/980 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 EKPEIRMVDPKVGDIPVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVAT--SISNG 314
            |.|..|:|      :|:.:      |||...|.:.        .|.||::.:..:|.|  ::.||
  Fly    40 ENPMQRLV------VPLAD------EDNYRLPYDT--------IPSHYAVSLSTNVHTGDTVFNG 84

  Fly   315 --SLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATF 377
              ::|:.:....:|:.        ||...:.|. ....:..|.:.| ..|:|.::.:...:..||
  Fly    85 TVAITLSVLNTTTKIV--------VHARQLENF-TASIIQQGVTEA-VAQELVYEYEAEREFLTF 139

  Fly   378 VINLSKT-LAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFP 441
                ||| |........:|::::...:.....|.|.::||: :..|.:::.:|||...|||.|||
  Fly   140 ----SKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYTD-EEGNTKYLATTQFESTDARHAFP 199

  Fly   442 CFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVD 506
            |:|.|..:|.|:|:|.....:. |:||||...|.  ..|.  ..|:.|..||:||||||||..|.
  Fly   200 CYDEPSKRAEFTITIKHDPSYN-AISNMPVDSSS--TSGV--TVFQKTVNMPSYLVAFIVSEFVF 259

  Fly   507 SRLASQDSGLTPRV---------EIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLV 562
            |.  .:.:||..||         :.|...  .||      :|.|.|..|   |.:...|||:|..
  Fly   260 SE--GELNGLPQRVFSRNGTEHEQEWALT--TGM------LVEKRLSGY---FDVPFALPKLDQA 311

  Fly   563 SVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDD 627
            .:|||...|||||||.|:|:..||...:....|:..:   :|.|.|||.||.|||:||..:||..
  Fly   312 GIPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTN---IATIEAHEDAHMWFGDLVAIEWWSF 373

  Fly   628 LWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDP 692
            ||||||||......|::.|:||:....|.....::.::.:||...:..:|..|:..:::..::|.
  Fly   374 LWLKEGFATLFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLYDS 438

  Fly   693 ISYSKGTILLRMLNSIVGDVAFRSATRDLL--KKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSV 755
            :||:|...:|.|....:.:..|:....:.|  .:|...|..:  |:..:.:...|:....| .:|
  Fly   439 VSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSK--LFEAIAKAAVEENYEVK-ATV 500

  Fly   756 KQIMDSWITQPGYPVVNVERR--GADLVLRQERYLLPSKNTADQSTWFIPITF---ETDELRKGD 815
            ..:|.||..|.|.|::.|.|.  .....::|..| ...|:..:...|::||.:   :..:.|..:
  Fly   501 PDMMGSWTNQGGVPLLTVTRNYDNGSFTVKQSVY-TNDKDYTNDKLWYVPINYAESKNPDFRNTE 564

  Fly   816 NIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQ--GYYRVNYDMTSWLALKKNFSTLPR- 877
              .||::.::.|..:.        |:.|...:|.||::  |||||.||..::..:.....|.|.
  Fly   565 --ATHYLLNQSEITIY--------SDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITRPHK 619

  Fly   878 ---ITRAQLLDDAL---------HLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLIY 930
               ..||||::|..         |.:..|.||| :|         ..|....|.|....:..|..
  Fly   620 IDPRNRAQLINDLYRFATSGRVPHATLLELLTY-LP---------QEDQYSPWSATNTVITLLNR 674

  Fly   931 NLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKF 995
            .|..:..|..|:.:::.:|...||.:|:::...:.||....|.::...||....:.|..:...|.
  Fly   675 YLSGDADYGNFQFYVRELVSLQFDKFGVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKL 739

  Fly   996 REWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLL 1060
            ...:.:  ...|:|||:|.:||..|.:.....:.|.:.:...:|..:|:..::::|||:.....|
  Fly   740 TALVEE--GTKIEPNLQSQVYCNGLKQADDKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQL 802

  Fly  1061 SKYLNMTINPTSGILKQDGALAFRAVASNA-IGHEIAFDFLQGNIKEIVEYYGD------GFSTL 1118
            .|::..:|.| .|:..|:.......|.|.. :|..:|.:|||.|    .|.||.      |.:.|
  Fly   803 EKFVYSSIEP-EGLRDQERITVLSPVYSRGEVGLLVAIEFLQKN----WEKYGQLNSGFGGVNPL 862

  Fly  1119 SEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALE-QVNNNIYWRSHSYHSLKNFL 1182
            ...|..::.|...|..|..|.:|..|.:  |...|.|.::.::: .||.|..|.:.:...|..::
  Fly   863 YSDIVGISAYTVNDKQKDALQELVDTVK--GSEYVPSTLQDSVDSNVNANYAWLASNRDPLMTWV 925

  Fly  1183 EGIVS 1187
            .|..|
  Fly   926 AGFRS 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	130/415 (31%)
		M1_APN_2	297..769	CDD:189008	145/487 (30%)
		ERAP1_C	846..1138	CDD:288671	78/313 (25%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	131/429 (31%)
		M1_APN_2	65..514	CDD:189008	145/487 (30%)
		ERAP1_C	587..905	CDD:288671	84/336 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448471
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.040