DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and CG5849

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_650979.1	Gene:	CG5849 / 42556	FlyBaseID:	FBgn0038897	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	238/947 - (25%)
Similarity:	399/947 - (42%)	Gaps:	101/947 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 MVDPKVGDIP------VVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSV--ATSISNG 314
            |:.|..|.:.      :|..:.||.|        |.|:|.....||.|.|.|...:  ...:.:|
  Fly     1 MITPPSGVVVLVTLGLLVSGSMGERE--------RSLRLPNATYPLFYQLHISSDIHKGQLLFSG 57

  Fly   315 SLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVI 379
            :.||    ||:...|...|||...|::...:.|.|.:|:|    ||..| |.........|..:|
  Fly    58 NATI----DVAIRQSTNEIVLHAKNLTDIQITVHRLMAEG----SEIVD-DLTHTLHPTAALLII 113

  Fly   380 N-LSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCF 443
            : :....|.|...:..|.:.:.:.:.....|:|...|.:.:..:..::.:||..|...|..|||:
  Fly   114 HPIENYQAFEEGQQYRLEILYTAIMASRPAGLYYMDYRDEENNHTVYVAATQCEPTYGRLIFPCY 178

  Fly   444 DRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIR-DDFETTPKMPTYLVAFIVSNMVDS 507
            |.|..|:||||.|....... |:||||.  ......|.:: ..|.|||.:.||||||::|:.  .
  Fly   179 DEPGFKSNFSIKITHGSSHS-AISNMPV--KEVLAHGDLKTTSFHTTPPISTYLVAFVISDF--G 238

  Fly   508 RLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAM 572
            .::....|:|.  .|:|.|........|.|...:.:...||:||:...|||:|.|::.....|||
  Fly   239 SISETYRGITQ--SIYTSPTSKEKGQVALKNAVRTVAALEDYFGVSYPLPKLDHVALKKNYGAAM 301

  Fly   573 ENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACY 637
            |||||||::|..||    ..::|..:..::......||:|||||||||:|:||...|:.||||.|
  Fly   302 ENWGLITYKDVNLL----KNISSDGQKRKLDLITQNHEIAHQWFGNLVSPEWWTYTWMNEGFATY 362

  Fly   638 MSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNT--------SHAISFDVRSTNDVRRIFDPIS 694
            .||...:..:|..:.||..        |.|:||:.        .|.:|..|....|:..:||.||
  Fly   363 FSYVITDLIYPNDKMMDMF--------MTHEADSAYSYNSFFDVHPMSHYVEGEKDIMGVFDIIS 419

  Fly   695 YSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQ-----GTLPKDLS 754
            |.:|..:::|.:.......|.......|:|:.|...:..:|:..|  |...|     ...|....
  Fly   420 YKRGACVIKMFHHAFRQKLFVRGISHFLEKYRYSVANELNLFDAL--HSELQDDEYFSHQPWASR 482

  Fly   755 VKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQSTWFIPITFETDELRKGDNIPT 819
            :::||.||......|::.|.|...:..:   .:...|.:..|: .|:|||.|.|.:....::...
  Fly   483 IREIMLSWTHSEWLPILVVTRNYENNTI---TFTQRSVHMKDE-LWWIPINFATTQSPNFEDTQV 543

  Fly   820 H-WMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQ--GYYRVNYDMTSWLA----LKKNFSTLPR 877
            . :|..:.:..:.:.::..|.|..|   ::.:|:|  |:|.|.||..:.:|    |:.|.|.:..
  Fly   544 DMFMPPQPQYTVSLEDLNIHVSGRD---WIMVNKQHTGFYLVRYDTDNLMAIARQLQTNHSVIHP 605

  Fly   878 ITRAQLLDDALHLSQAEYLTYDIPLTF-LMELFDAVDDELLWIAAKPGLNYLIYNLKREPAYETF 941
            |.|..|..|...|.:...:. .:.:.| |::..:..:|.|.|...:..:..|..||....:...|
  Fly   606 INRLGLFRDLGPLIEHNEIE-QVEVVFELLKYLELEEDVLTWNQLQDTIECLTRNLHGTSSQSLF 669

  Fly   942 RAFMKFIVRPAFDHYGLHEPDNESHLQLKHRAL---VAYFACKFNYDRCTQKAQMKFREWMRDP- 1002
            ..|::.:|.|.|....:     |..:.|....:   :...||..:...|.:..:...:|.:.|.
  Fly   670 NEFVRRLVGPTFRRVYV-----EQGVNLAEDGMFRGILEIACSADLPECLEYTRRLAKEHIIDKI 729

  Fly  1003 --KNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSAS-EKEEILTSLGCTTKPWLLSKYL 1064
              |:......:...:.|..:...|..::.......:....|| ..::|:.:|.||.....|..||
  Fly   730 YFKDGSDYHAIIDSVLCMGVRYLSDQDFQRIIDMMQEIDRASVYYDDIIYALRCTQSHRHLLYYL 794

  Fly  1065 N--MTINPTSGILK--QDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSL 1125
            .  |..|.|..:|.  :|.........||.....:.:.:::.|.|.:..     .....|..|.|
  Fly   795 EGLMGENSTHMVLSEFEDLMYLLYIYKSNLASRPVIWQYIERNYKVLCR-----APNFLEHFKQL 854

  Fly  1126 TIYMNKDYHKH-QLL--DLAATCRKLGLHAVESAIEL 1159
            ..::.:....| :.|  .:|....:.||:..::.||:
  Fly   855 AGFVPRHQRSHFERLRQTIANHMMQEGLNTNQTLIEV 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	131/413 (32%)
		M1_APN_2	297..769	CDD:189008	145/488 (30%)
		ERAP1_C	846..1138	CDD:288671	61/310 (20%)
CG5849	NP_650979.1	Peptidase_M1	30..423	CDD:279741	132/420 (31%)
		M1_APN_2	38..497	CDD:189008	145/488 (30%)
		ERAP1_C	570..>841	CDD:288671	57/276 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448469
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.950