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Protein Alignment CG46339 and LNPEP

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	1219	Identity:	328/1219 - (26%)
Similarity:	523/1219 - (42%)	Gaps:	266/1219 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FTNPKLQIP--LMASAIY--APTTITTNTTSTAGTPTSAKNASASASASASASLSSPAGPSAAGS 85
            |||.:||:|  ::.::::  .|..:..                      |......|..|.
Human     4 FTNDRLQLPRNMIENSMFEEEPDVVDL----------------------AKEPCLHPLEPD---- 42

  Fly    86 ASTSSAPAGGGPWQGLVAKLRNFKLDDTKNIRKRFHFDYISKDRFLG--------GQLKTKNGQK 142
             .....|.|.   :.||..|...::::.:.       ||.|..:.||        |...:..|
Human    43 -EVEYEPRGS---RLLVRGLGEHEMEEDEE-------DYESSAKLLGMSFMNRSSGLRNSATG-- 94

  Fly   143 YVFNGPPSGVYVSKAC-------LIIAAFITVLALLFTIAITYFV-----TRQGLNPKEVTPPSC 195
              :...|.|     ||       :::.||:.|:| :..|.:.|.:     |::|.:.|.
Human    95 --YRQSPDG-----ACSVPSARTMVVCAFVIVVA-VSVIMVIYLLPRCTFTKEGCHKKN------ 145

  Fly   196 ITADHPDVNATPIQTAGWVSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVD 260
                         |:.|.:.                       |..|.....|.:    :||:..
Human   146 -------------QSIGLIQ-----------------------PFATNGKLFPWA----QIRLPT 170

  Fly   261 PKVGDIPVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVS 325
            ..|                                ||.|.|.:.|::.:....||:||.::  ..
Human   171 AVV--------------------------------PLRYELSLHPNLTSMTFRGSVTISVQ--AL 201

  Fly   326 KVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQ 390
            :|| |. |:|.....:||.|..:.|:      :|:|:..:. .:|.......::.....||..
Human   202 QVT-WN-IILHSTGHNISRVTFMSAV------SSQEKQAEI-LEYAYHGQIAIVAPEALLAGH-- 255

  Fly   391 LRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNE-EWMISTQFSPVDARRAFPCFDRPDMKANFSI 454
             ...|.:::.:.::.:..|.|..|||  |..|| ::..:|||.|:.||.||||||.|..||.|.|
Human   256 -NYTLKIEYSANISSSYYGFYGFSYT--DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFII 317

  Fly   455 SIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPR 519
            .|:|..|: .|||||||..|.....|.::|:|..:.||.||||||||..|   :..|||...| .
Human   318 KIIRDEQY-TALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEM---KNLSQDVNGT-L 377

  Fly   520 VEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSA 584
            |.|:..|:.:|..|||.:...|.|.:::::|.|:..|.|:|||::|||...|||||||:|||:..
Human   378 VSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREET 442

  Fly   585 LLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPE 649
            ||...:   .||....::|..||||||||||||||||.|||:||||.||||.:|.|.:||....|
Human   443 LLYDSN---TSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKE 504

  Fly   650 FQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAF 714
            ..|.:......|| :|:.|:.|:||.||..|:|:..:..:||.:||.||:.||.||.:.:.:..|
Human   505 LSSYEDFLDARFK-TMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVF 568

  Fly   715 RSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGAD 779
            :.|....|...:|.::..||||.....      ...:.|.||::|.:|..|.|:|:|.|:::|.:
Human   569 QHAVVLYLHNHSYASIQSDDLWDSFNE------VTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKE 627

  Fly   780 LVLRQERYLL---PSKNTADQS-TWFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSS 840
            |.::|||:.|   |....:|.| .|.||:::.|:    |.|...:...|..:::..|.|:
Human   628 LFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTE----GRNYSKYQSVSLLDKKSGVINL----- 683

  Fly   841 NSDNVIY--LNLNRQGYYRVNYDMTSWLA----LKKNFSTLPRITRAQLLDDALHLSQAEYLTYD 899
             ::.|::  :|:|..|||.|:|....|.|    ||.|...|....||.|:::...|:...    .
Human   684 -TEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLG----K 743

  Fly   900 IPLTFLMELFDAVDDELLWIAAKPGLNY------------LIYNLKREPAY---------ETFRA 943
            :||....:|.:.:.:|          |:            |||||..:..|         ..|:.
Human   744 VPLKRAFDLINYLGNE----------NHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKL 798

  Fly   944 FMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIK 1008
            ....|.:..:...|     ..|..:|  |:.:..|||..|...|:..|...|.:||.......:.
Human   799 LQNQIQQQTWTDEG-----TPSMREL--RSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLP 856

  Fly  1009 PNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKP----WLLSKYLNMTIN 1069
            .::.:.::  .:...:...|.|...:|.:..|.:||.:||.:|..:...    ||:...||
Human   857 TDVMTTVF--KVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLN---- 915

  Fly  1070 PTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYH 1134
             ......|..:...|.|..:..||.:|:||::.|..::|:.:..|..|:..::...|...:...|
Human   916 -GDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTH 979

  Fly  1135 KHQLL-----DLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSL 1178
            ..::.     ...||.|   |..|:.|:|:    :..||.|...:..||
Human   980 LSEVQAFFENQSEATFR---LRCVQEALEV----IQLNIQWMEKNLKSL 1021

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.