Protein Alignment CG46339 and erap1b

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_956500.2
• Gene: erap1b / 393175
• ZFINID: ZDB-GENE-040426-934
• Length: 963
• Species: Danio rerio
• Alignment Length: 1044
• Identity: 300/1044 - (28%)
• Similarity: 478/1044 - (45%)
• Gaps: 190/1044 - (18%)

  Fly   234 TPTNTPTVTTTLAMPASSEKPEIRM---VDPKVGDIPVVEPAAGEVEDNTTKPINRPLKLYEGWR 295
            |.|..|.:...:.:|       |.:   |.|:....|:  .::||     ..|.|: ::|.:...
Zfish     3 TMTRLPVLLNLIVLP-------IHLWAAVTPEPTSFPI--SSSGE-----PFPWNK-MRLPDTIS 52

  Fly   296 PLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNASE 360
            ||||:|||.|::.:....||:.|:||    .:...:.|:|...|:.||:.|::.|      |.::
Zfish    53 PLHYNLLIHPNLTSLDFTGSVQIQIE----VLQDTKTIILHSKNLQISSARLLDA------NIAQ 107

  Fly   361 EQDLD-FDSDYGEDNATF----VINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDT 420
            :|.|. .:..|.:..|..    ::......:||        |.|.:.::::..|.||::|..  :
Zfish   108 QQPLKVLEYPYFQQIALVSDKALLKRGHVYSVE--------LHFAANLSESFHGFYKSTYRT--S 162

  Fly   421 KNEEWMI-STQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRD 484
            |.:..:: ||||....||.||||||.|..|||||:.|.|..: .:|||||||..:...:.|...|
Zfish   163 KGDVRVVASTQFEATSARAAFPCFDEPAFKANFSVQIRREAK-HIALSNMPKLRTLELKNGLFED 226

  Fly   485 DFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDF 549
            .|:.:.||.|||||:|||:.:.....||..   .::.::..|:.:....:|.....|.|.:|:|:
Zfish   227 QFDVSVKMSTYLVAYIVSDFLSISKTSQHG---VQISVYAVPEKIDQAEFALDAAVKLLDFYDDY 288

  Fly   550 FGIKNKLPK--------------------IDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLA 594
            |.|...|||                    :||.::|||...|||||||.|:|:||||.  |...:
Zfish   289 FDIPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLF--DPHKS 351

  Fly   595 SSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTML 659
            |:|:.:.:.. ||||||||||||||||.:||:||||.||||.:|.:.::...:||.|..|.....
Zfish   352 SASDKLGITM-IIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQVEDYFLGK 415

  Fly   660 EFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKK 724
            .| |:||.|:.::||.:|..|.:...::.:||.:||.||..:|.||...:....|:......||.
Zfish   416 CF-EAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKYLKH 479

  Fly   725 FAYGNMDRDDLWAMLTR----HGHEQGTLPKD--------------------LSVKQIMDSWITQ 765
            ::|.|....:||..||.    .|.::|.|..|                    |.||.:|::|..|
Zfish   480 YSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMMETWTLQ 544

  Fly   766 PGYPVVNVERRGADLVLRQERYLLPSKNTADQST--WFIPITFETDELRKGDNIPTHWMRSEDEE 828
            .|:|::.:..:|.::.|.|||| |.|.:.:..|:  |.:|:|:.|     .|:...|
Zfish   545 EGFPLITIAVKGREVRLSQERY-LKSDDLSQTSSFLWQVPLTYIT-----SDSTTVH-------- 595

  Fly   829 ELIVGNVFAHSSNSDNVIYL---------NLNRQGYYRVNYDMTSW----LALKKNFSTLPRITR 880
                  .|...:.:| |:||         |::..|||.|:|:.:.|    ..||.|.:.|....|
Zfish   596 ------RFLLKTKTD-VLYLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSNDR 653

  Fly   881 AQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLI--YNL--KRE------ 935
            |.|:::|..|.....|..|..|.  :.|:.:.:.|::.:.  .|.|.|:  |.|  ||:
Zfish   654 ASLINNAFQLVSVGKLPLDKALD--LTLYLSKETEIMPVT--QGFNELVPLYKLMEKRDMVELEN 714

  Fly   936 --PAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAY---FACKFNYDRCTQKAQMKF 995
              ..| ..:.|.|.|.:..:...|          .:..|.|.:|   |.|...:..|...|...|
Zfish   715 QMKGY-ILQLFQKLIEQQLWTDEG----------SVSERMLRSYLLLFGCVRGHPPCVSNATQLF 768

  Fly   996 REWMRDPKNNPIKPN-LKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKP-- 1057
            ..| ||...|...|| :...::  |:...:...|.|.:::||.:...|.|..|..:|  .|.|
Zfish   769 NLW-RDSDGNMSLPNDVTMAVF--SVGARTEDGWDFLFEKYKESMYVSMKSRIKQAL--MTSPLD 828

  Fly  1058 ----WLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTL 1118
                |::.:.|...:     |..||......:|:.|...::.|:||||.|...:::.:..|..::
Zfish   829 HKLKWMMEQSLEGEL-----IKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSI 888

  Fly  1119 SEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIEL-----ALEQVNNNIYWRSHSYHSL 1178
            :.|:..:|    ..|...::  ||.......|...|:..||     |:|.:..||.|...:...|
Zfish   889 AHMVVGVT----NQYSTREM--LAEVRNFFSLLQPETGAELRCIQQAVENIEENIRWMDKNLPLL 947

  Fly  1179 KNFL 1182
            |.:|
Zfish   948 KAWL 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	174/516 (34%)
		ERAP1_C	846..1126	CDD:463368	75/314 (24%)
erap1b	NP_956500.2	M1_APN-Q_like	54..543	CDD:341064	174/516 (34%)
		ERAP1_C	614..934	CDD:463368	83/350 (24%)