DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and CG3502

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	257/935 - (27%)
Similarity:	444/935 - (47%)	Gaps:	89/935 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 LYEGWR------PLHYSLLIEPSVATSISN------GSLTIE-IERDVSKVTSWEPIVLDVHNVS 341
            :||.:|      ||||:|    .:.|.:::      ||:||: :.|:.:|            |::
  Fly    24 VYEDYRLPRSVEPLHYNL----RILTHLNSTDQRFEGSVTIDLLARETTK------------NIT 72

  Fly   342 ISNVRVIRALADGASNASEEQDLDFDS-DYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTD 405
            : :...::...:..|..|.::....:. :..|.:..::::|.:.| |:.|: ..|.:.|.:.:.|
  Fly    73 L-HAAYLKIDENRTSVVSGQEKFGVNRIEVNEVHNFYILHLGREL-VKDQI-YKLEMHFKAGLND 134

  Fly   406 TLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMP 470
            :..|.||::||:..||....:..|||||..||:||||||.|..||.|:|::....:: |.||.||
  Fly   135 SQSGYYKSNYTDIVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKY-MGLSGMP 198

  Fly   471 --KSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRV--EIWTRPQFVGM 531
              :.........::..|.:|..:..||||||.|.::.::  |:::|..:.||  ..|.:|:.:|.
  Fly   199 VLRCQDHDSLTNYVWCDHDTLLRTSTYLVAFAVHDLENA--ATEESKTSNRVIFRNWMQPKLLGQ 261

  Fly   532 THYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASS 596
            ...:.::..|.|.:||:.|.|...|.|:|.::||...|.|||||||:|:.:..|  |:: |....
  Fly   262 EMISMEIAPKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERL--PQN-QGDYP 323

  Fly   597 SEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEF 661
            .:.....|..:|||.||||||||||..||:|||||||.:.|..|.||:...||::..:.....:.
  Fly   324 QKQKDSTAFTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDL 388

  Fly   662 KESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFA 726
            ......|::.|..|||.||::..:|...|....|.||::.:|||:.:||:.||....|..|::|:
  Fly   389 ANFFSKDSNATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFS 453

  Fly   727 YGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVER--RGADLVLRQERYLL 789
            :||:.:.|||..|.....:...:..|.::.:.||||..|.|||:|.:.|  :..::.|.|.|:..
  Fly   454 FGNVAQADLWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQ 518

  Fly   790 PSKNTADQSTWFIPITFETDELRK-GDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQ 853
            ........|.|::|:.|....|.. ....|..|:......:::  .:..|.| :|..:.||....
  Fly   519 EHGIEKASSCWWVPLRFVRQNLPDFNQTTPQFWLECPLNTKVL--KLPDHLS-TDEWVILNPQVA 580

  Fly   854 GYYRVNYDMTSW------LALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAV 912
            ..:|||||..:|      |....|...:.::.:||||||.:.|:......||.... |:|.....
  Fly   581 TIFRVNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFD-LLEYLKKE 644

  Fly   913 DDELLWIAAKPGLNYL--IYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALV 975
            .|.|.|..|...||.|  :.|:...   ..|:.:|:.::.|.::.:.......|:...:|....
  Fly   645 QDFLPWQRAIGILNRLGALLNVAEA---NKFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPF- 705

  Fly   976 AYF----ACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYK 1036
            |:|    ||:::...||.:|:: .....|......:..:.:.|.||:.|.||...|:...:..::
  Fly   706 AHFAYSQACRYHVADCTDQAKI-LAITHRTEGQLELPSDFQKVAYCSLLDEGGDAEFLEVFGLFQ 769

  Fly  1037 TTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQ 1101
            .:|:.|::..:.::|||........::||.|:.....:|.....||.::..:.........:::.
  Fly   770 NSTNGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTANYII 834

  Fly  1102 GNIKEIVEYYGDGF--STLSEMIKSLTIYMNK----DYHKHQLLDLAATCRKLGLHAVESAIELA 1160
            .:.|::    |:.|  ..|:.::.||...:..    |..|.||.|         |...|..::.|
  Fly   835 SHAKKL----GEKFKKKELTGLLLSLAQNLRSTEEIDRLKAQLED---------LKEFEEPLKKA 886

  Fly  1161 LEQVNNNIYWRSHSYHSLKNFLEGI 1185
            |.|...|..|:.   ....:|:|.|
  Fly   887 LYQGKMNQKWQK---DCSSDFIEAI 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	131/413 (32%)
		M1_APN_2	297..769	CDD:189008	155/483 (32%)
		ERAP1_C	846..1138	CDD:288671	68/309 (22%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	132/420 (31%)
		M1_APN_2	37..496	CDD:189008	155/483 (32%)
		ERAP1_C	573..890	CDD:288671	75/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462091
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.950