Protein Alignment CG46339 and Trhde

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001102461.1
• Gene: Trhde / 366894
• RGDID: 728895
• Length: 1066
• Species: Rattus norvegicus
• Alignment Length: 962
• Identity: 288/962 - (29%)
• Similarity: 468/962 - (48%)
• Gaps: 116/962 - (12%)

  Fly   262 KVGDI-----PVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIE 321
            ::|::     |...|.: |.|....:|..: |:|....:||||:|::...:.....:|.:.:||.
  Rat   152 EIGEVGTAGTPSAHPPS-EEEQEQWQPWTQ-LRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIA 214

  Fly   322 RDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNAS------EEQDLDFDSDYGEDNATFVIN 380
              ....|.:  :||....|::..|:|....|.||...:      :.|.|             |:.
  Rat   215 --CQNATRY--VVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVL-------------VVV 262

  Fly   381 LSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDR 445
            |::||  :.|....|.:.:.:.:.:.|.|.:::||.....:  .::..|||||..||:||||||.
  Rat   263 LNRTL--DAQRHYNLKIIYNALIENELLGFFRSSYVIHGER--RFLGVTQFSPTHARKAFPCFDE 323

  Fly   446 PDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLA 510
            |..||.|.|||.....: ::|||||...|.....|::.|.|..||.|.||.:|:.:.|.. .|..
  Rat   324 PIYKATFKISIKHQATY-LSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFT-YRET 386

  Fly   511 SQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAME 573
            :..||:.  |.::.||..:  |...||..:.::.:.:|||:|.:...|||:||::||...:||||
  Rat   387 TTKSGVV--VRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAME 449

  Fly   574 NWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYM 638
            ||||..|.:..:|:...:   ||..::..|..:|.||:.|||||:||||.||:|:|||||||.|.
  Rat   450 NWGLSIFVEQRILLDPSV---SSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYF 511

  Fly   639 SYKALEHAHPEFQSMDTLTMLE--FKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTIL 701
            .:...::.:|.: :|:....|.  ..|.|..|...:||.:|.:|....|:.::||.|:|.||..|
  Rat   512 EFVGTDYLYPSW-NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDKVFDWIAYKKGAAL 575

  Fly   702 LRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQP 766
            :|||.:.:|...|:...:|.|....|||..|:|||..|:......|   |.::::::||.|..|.
  Rat   576 IRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG---KYVNIQEVMDQWTLQM 637

  Fly   767 GYPVVNV------ERRGADLVLRQERYL--LPSKNTADQ-----STWFIPITFETDELRKGDNIP 818
            ||||:.:      |.|   :::.|:.::  :.:|..|.|     ..|.||:|.....
  Rat   638 GYPVITILGNMTAENR---ILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGN-------- 691

  Fly   819 THWMRSEDEEELIVGNVFAHSSNSDNVIYL--------NLNRQGYYRVNYDMTSWL----ALKKN 871
                ||....|.|:.  .::.|....:.||        |:|:.||:|||||:.:|.    .|.:|
  Rat   692 ----RSHVSSEAIIW--VSNKSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRN 750

  Fly   872 FSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLIYNLKREP 936
            ...|....||.|:|||..|::|.||..:|||..:..|.:. .|.|.|.||...|..|...|.|
  Rat   751 HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEE-KDFLPWHAASRALYPLDKLLDR-- 812

  Fly   937 AYETFRAFMKFIVRPAFDHYG-LHEPDNE----------SHLQLKHRALVAYFACKFNYDRCTQK 990
             .|.:..|.::|::.....|. |..|.|.          .|.:|:...::  .||.|....|.|:
  Rat   813 -MENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEELRREVIM--LACSFGNKHCHQQ 874

  Fly   991 AQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTT 1055
            |.....:|:...:|. |..|::.::|||.::......|.|.:.::.:||:.|||:.:|.:|.|:.
  Rat   875 ASTLISDWISSNRNR-IPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSD 938

  Fly  1056 KPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSE 1120
            ...|||:.||:::| :..:|.||.......||.|..|.::|:.|.:...|.:...||:.....|:
  Rat   939 DRNLLSRLLNLSLN-SEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 1002

  Fly  1121 MIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESA-IELALEQVNNNIYWR 1171
            :|..:|.::|.:....:|.:...:     ...|.|| ...|:|.|..|:.|:
  Rat  1003 LISGVTEFLNTEGELKELKNFMKS-----YDGVASASFSRAVETVEANVRWK 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	158/476 (33%)
		ERAP1_C	846..1126	CDD:463368	90/302 (30%)
Trhde	NP_001102461.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..177		5/25 (20%)
		M1_APN-Q_like	190..635	CDD:341064	158/476 (33%)
		ERAP1_C	720..1044	CDD:463368	97/336 (29%)