DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and lnpep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	1111	Identity:	296/1111 - (26%)
Similarity:	491/1111 - (44%)	Gaps:	213/1111 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 DYISKDRFLGGQLKTKNGQK------YVFNGPPSGVYVSKACLIIAAFITVLALLFTIAIT---- 177
            ||.|..|.||.....::..:      |....|      |.:|..::...|.:.:|..:.:.
Zfish    78 DYESSARLLGMSFMNRSSSQRSAASSYTRQQP------SNSCSPLSTKTTAVGVLILVLVVSMFM 136

  Fly   178 --YFV-----TRQGLNPKEVTPPSCITADHPDVNATPIQTAG----WVSMNSPPPLQAATPTPMA 231
              |||     |::|          |..::....:..||.|:|    |
Zfish   137 VIYFVPSCTFTKKG----------CQKSNSSMSSIYPISTSGELFPW------------------ 173

  Fly   232 SPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDNTTKPINRPLKLYEGWRP 296
                       |.|.:|.|.                                           .|
Zfish   174 -----------TDLRLPVSV-------------------------------------------HP 184

  Fly   297 LHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVH---NVSI--SNVRVIRALADGAS 356
            :||::.:.|.:.:....|:::|              :||.:|   |:.:  |::.:|:...|.
Zfish   185 VHYNISLHPDLNSMTFQGNVSI--------------VVLVMHETKNIILHSSDMNIIKVTFDD-- 233

  Fly   357 NASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTK 421
              .|.:.|:: ..:.:....|..:|.|.       :.:|...:.:.::::..|.|.:||.  ||.
Zfish   234 --KEYRFLEY-KPWQQIAIKFPEDLKKG-------QYVLKFSYKANLSNSYDGFYNSSYV--DTA 286

  Fly   422 NEEWMI-STQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRF-RRGFIRD 484
            ..:.:: :|||.|:.||:||||||.|..|:.|.:.:.|..:: ::||||||..:... ..|...|
Zfish   287 GTKRVLAATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKY-ISLSNMPKIKTTDLNENGLQED 350

  Fly   485 DFETTPKMPTYLVAFIVSNMVD-SRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYED 548
            :||::.||.||||||||:.... |:..|:.:     |.::..|......|||.:...|.|.:|..
Zfish   351 EFESSVKMSTYLVAFIVAEFSSHSKNVSKTT-----VSVYAVPDKKDQVHYALETACKLLKFYNT 410

  Fly   549 FFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAH 613
            ||.|:..|.|:|||::|||...|||||||||||::.|||...    ||....|:|..:|||||||
Zfish   411 FFEIEYPLSKLDLVAIPDFLAGAMENWGLITFRETTLLVGNQ----SSRFDKQLVTSVIAHELAH 471

  Fly   614 QWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISF 678
            ||||||||.:||:||||.||||.||.|.::|:..|:.........:.|| ::..||.|:||.:|.
Zfish   472 QWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPDLDIDIEFLNVRFK-ALAKDALNSSHPVST 535

  Fly   679 DVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHG 743
            .|.:...|..:||.:||.||..:|.|||:.:.|..|.....:.|:.:...|.:..|||..|::
Zfish   536 FVSTPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHKGVIEYLQNYNLSNTESKDLWNSLSQ-- 598

  Fly   744 HEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKN-TADQSTWFIPITFE 807
                ...:.|:|.::|::|....|:|:|.|:|.|..:.|.||.:||.::| |.|.|.|.||:|:.
Zfish   599 ----VSKQSLNVSEMMNTWTVHKGFPLVTVKRNGPQVTLSQEHFLLNAENGTDDSSLWHIPLTYV 659

  Fly   808 TDE---LRKGDNIPTHWMRSEDEEEL--IVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW-- 865
            .|.   ||....:    ...:|:|..  :.|.|        ..:..|....|:|.|:||...|
Zfish   660 NDSCSVLRSCKQV----FHLKDKEATLQLPGQV--------KWLKFNFRSDGFYIVHYDEQGWSD 712

  Fly   866 --LALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYL 928
              .|||.:.:.||...:|.|:::...||:...:::    ..::.|.|.:.:|.........|:.|
Zfish   713 LISALKVDVNVLPSEDKAALINNIFALSRLGKVSF----RQVLNLMDYIRNETETAPLTEALSQL 773

  Fly   929 --IYNLKREPAYETFRAFMKFIVRPAFDHYG-LHEPDN----ESHLQLKHRALVAYFACKFNYDR 986
              ||.|..:.:.....:.|...:.   .|:| |.|..:    .|..::..|:.:...||..|...
Zfish   774 GQIYRLLDKRSDLNLASSMTTYIE---SHFGSLMESQSWEVETSVSKMTLRSALLETACALNRPN 835

  Fly   987 CTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSL 1051
            ||.:|:..|.:|:...|...|..:|...::  .:|..:...|......||.:...:||.::|.:|
Zfish   836 CTTQARRLFDQWLASNKTLQIPSDLMRTVF--KVAAKTDEGWSKLLGSYKHSIYDTEKRKMLEAL 898

  Fly  1052 GCTTKP----WLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYG 1112
            ..|...    |:|.|.|:     .|.|..|:..|....|..:..|:..|:||::.|.::|.:.:.
Zfish   899 ASTQDVRKIIWVLQKSLD-----GSEIQNQEFPLVIHTVCRDFAGYLYAWDFMKENWEKITQKFP 958

  Fly  1113 DGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAI-ELALEQVNNNIYWRSHSYH 1176
            .|...:..:|.|.|...:...|   |.::......||....:..| :.|:|.:.:|:.|...:.:
Zfish   959 IGSFAIQSIITSTTSQFSTKTH---LAEVQNFFSSLGAKGSQMRIVQEAIETIKHNMRWMEKNLN 1020

  Fly  1177 SLKNFL 1182
            :|:::|
Zfish  1021 TLQSWL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	144/409 (35%)
		M1_APN_2	297..769	CDD:189008	162/479 (34%)
		ERAP1_C	846..1138	CDD:288671	71/306 (23%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	162/479 (34%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	77/335 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850