DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and CG2111

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	945	Identity:	259/945 - (27%)
Similarity:	446/945 - (47%)	Gaps:	110/945 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PLHYSLLIEPSVATSIS------NGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADG 354
            ||.|.:    .:.|.|:      .|::.|::..:    .|.:.|||:.|:::|...|.: .|:|.
  Fly    32 PLSYRV----DIVTRINQPYQPFGGTVVIDLRSE----RSTKRIVLNAHDLAIGKRRAV-TLSDK 87

  Fly   355 ASNASEEQDLDFDSDYGEDNATFVINLSK-TLAVETQLRV----LLSLDFVSQVTDTLQGIYKTS 414
            ..|:.....:..|           |.||: |::::..|:|    .:.:.|.|.:.:...|.|.::
  Fly    88 NGNSVPVSSIQMD-----------IKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSN 141

  Fly   415 YTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRR 479
            |.:.:|...:|:.:|||.|..||.||||||.|..:..|.|::..|..:: ||||||.  .|..|.
  Fly   142 YVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYR-ALSNMPV--QRTIRH 203

  Fly   480 GFIRD----DFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVR 540
            ..::|    .|..:..|.||||||::|........|.:....| :..|.||..:..|.:|..:|.
  Fly   204 ASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCP-ISTWARPDALSQTEFANMVVA 267

  Fly   541 KFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAG 605
            ..|.:|||.|....:..|||||::|||.|.:.|||||..|.:.:||.  |.| .||.:..|.||.
  Fly   268 PLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLY--DSQ-RSSIDDQQGVAR 329

  Fly   606 IIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDAD 670
            .:|..:.:|||||||:..||.::|||..||.|:|...:....||:...:...:..:...:::||.
  Fly   330 AVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAH 394

  Fly   671 NTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDL 735
            ..:..::..|...:.:...::.|...|..:|..||:.::|:.|:.:|.|..|..:|.......|.
  Fly   395 VNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDF 459

  Fly   736 WAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVER----RGADLVLRQERYLLPS--KNT 794
            |.:|.......|.|.|.|::.:||..|:.|||||:|.|.|    |.| :|.:|..::.|.  ...
  Fly   460 WDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTA-IVSQQRFFITPQFRNRW 523

  Fly   795 ADQSTWFIPITFETDELRKGDNIP-THWMRSEDEEELIVGNVFAHSSNSDNV------------I 846
            |....|::|:::.....:..:.|. :.|:.....:.         ||.|:.|            |
  Fly   524 ARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKP---------SSKSNTVLLEKLEAEPTDWI 579

  Fly   847 YLNLNRQGYYRVNYDMTSWLALKK------NFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFL 905
            ..|:.....:|||||:.:|..|.|      .|..:.|:.||||:||...|:.:..:.||:.|..|
  Fly   580 LFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGIL 644

  Fly   906 MELFDAVDDELLWIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLK 970
            ..| :..|:.::|:|.:.....:....|..|.|..|:.:|:.::...|... :......|...:.
  Fly   645 GYL-EHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRV-ISSDLTSSSGNMT 707

  Fly   971 HRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSV-----IYCTSLAEGSSPEWYF 1030
            ||.::...||::....|...|:   ||:|   |..|.|....::     :.||::..|:..:...
  Fly   708 HRPVIIRLACEYELPACVSLAR---REFM---KGTPEKGGWMTIRERETVVCTAVKFGTEGDRDM 766

  Fly  1031 AYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEI 1095
            ....||.:..|:|||.:||:|.|:...:.|.:.|..|.. :||:.||:....|:||.||::|:.:
  Fly   767 VESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFE-SSGVRKQNARRTFKAVVSNSMGYRL 830

  Fly  1096 AFDFLQGNIKEIVEYYGDG----FSTLSEMIKSLT-----IYMNKDYHKHQLLDLAATCRKLGLH 1151
            |..::..|::.|..|..:.    .:.::.:|:.|:     :|.:| :.|..|.|         ::
  Fly   831 AKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSK-FFKEILRD---------MN 885

  Fly  1152 AVESAIELALEQVNNNIYWRSHSYHSLKNFLEGIV 1186
            ..|..|::.||:.|:||:|:...:..:...:..|:
  Fly   886 GSERLIKILLERGNDNIHWQRTKFRPMLQAIRDII 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	125/416 (30%)
		M1_APN_2	297..769	CDD:189008	147/486 (30%)
		ERAP1_C	846..1138	CDD:288671	81/311 (26%)
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	125/415 (30%)
		M1_APN_2	33..493	CDD:189008	147/486 (30%)
		ERAP1_C	579..897	CDD:288671	86/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462083
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950