DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and CG9806

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	242/921 - (26%)
Similarity:	424/921 - (46%)	Gaps:	91/921 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 RPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSW---EPIVLDVHNVSI-SNVRVIRALADG- 354
            |||||:|.:...|.....:|:.:.|:   :.::..|   ..|:|..:.:.: .||.::|....|
  Fly    28 RPLHYNLSLLTEVEPLKLSGNFSGEV---IIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGR 89

  Fly   355 -------ASNASEEQDLDFDSD--YGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGI 410
                   .:::..:..:.|:|.  .||: .|.|:..|..|               |:.:....|.
  Fly    90 VTVRKMWQASSVHQLGIVFNSMLWLGEE-YTLVVQFSGQL---------------SRASGYFVGG 138

  Fly   411 YKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMP--KSG 473
            |..|..:|     :|:..||.:|..|...||||:.....|.|.:::..| :...|:|||.  |:.
  Fly   139 YMDSKHHP-----QWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHP-RGTNAVSNMRVLKTS 197

  Fly   474 SRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKM 538
            ... :..::...|:.||.|....:||.::...:...|....|  |.:..|.||:......||..:
  Fly   198 DHE-KDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKG--PALTTWLRPKIADQGDYAISI 259

  Fly   539 VRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVV 603
            ..:.:.::...||......|||.:.:||..:.:.|:.||:::.::|.|....   .|::...|.|
  Fly   260 TPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQ---RSTTRAKQQV 321

  Fly   604 AGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHD 668
            |..:|.|.||.|..:|.....:   ||..|.:.|:|..|:::..|.::..:...:.:....:..|
  Fly   322 ASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVED 383

  Fly   669 ADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRD 733
            :.::::.:|....|.:.     |..:..|..:|.|||:|::|..||.:|.|..|::...|:....
  Fly   384 SKSSAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQ 443

  Fly   734 D-LWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERR--GADLVLRQERYLL-PSK-N 793
            . ||..|......|.:|.:|:.|.|:||||..|||||::.|.|.  ..::.:.|||:|. |.| .
  Fly   444 AFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLM 508

  Fly   794 TADQSTWFIPITFETDELRK-GDNIPTHWMRSEDEE---ELIVGNVFAHSSNSDNVIYLNLNRQG 854
            ...|..|::|:||.|..:.. ...:|:.|:..:..:   .||:..|    :..|..:..||....
  Fly   509 QKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEV----AQPDKWVVFNLRLAT 569

  Fly   855 YYRVNYDMTSWLALKK-----NFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDD 914
            ..|:.||..:|..:..     |.|::.|.|||||:.|.|:|:.|..:|||:.|.||..|.:. |:
  Fly   570 PCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNE-DE 633

  Fly   915 ELLWIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHE---PDNESHLQLKHRALVA 976
            .::|.||...|.:|...|::.....||:.||:.:::..||.....:   .:|.:..:|  ..:|.
  Fly   634 FIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITEL--MVIVL 696

  Fly   977 YFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSA 1041
            ..:|:.:.:.|...|..:|.....:....|:  :|...||||::..|:..:|....:.|..:..:
  Fly   697 QLSCRTDLESCADFALKEFAGLTLETNRIPV--DLSETIYCTAIQFGTEADWTLLRRLYTRSNVS 759

  Fly  1042 SEKEEILTSLGCTTKPWLLSKYLNMTINPTSG--ILKQDGALAFRAVASNAIGHEIAFDFLQGNI 1104
            .|:..:|:::.|:.:.|.|.|.||:..   :|  :.|.|..|.|.|||.|.:|:.||..:|..||
  Fly   760 EERRILLSAMACSRENWALDKLLNLAF---AGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNI 821

  Fly  1105 KEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRK--LGLHAVESAIELALEQVNNN 1167
            |.|::.||   |...|:.:.:|:.|.:...:.:|..|....|.  ..|...|.|....||...:|
  Fly   822 KAIIKLYG---SNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDN 883

  Fly  1168 IYWRSHSYHSL 1178
            |.|.:..||:|
  Fly   884 ISWHNRQYHNL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	92/417 (22%)
		M1_APN_2	297..769	CDD:189008	119/488 (24%)
		ERAP1_C	846..1138	CDD:288671	85/301 (28%)
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	91/327 (28%)
		Peptidase_M1	25..392	CDD:279741	90/397 (23%)
		GluZincin	30..480	CDD:301352	119/488 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950