DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and Aopep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_008769651.1	Gene:	Aopep / 290963	RGDID:	1309592	Length:	886	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	116/575 - (20%)
Similarity:	193/575 - (33%)	Gaps:	186/575 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 VLDVHNVSISNV---------------------RVIRALADGASNASEEQ--------------D 363
            ||.|..|.::.|                     .::|.|....::|..||              :
  Rat   217 VLKVEEVDVAAVPDLEKFTKAPNLTAAPEKRRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGE 281

  Fly   364 LDFDSDYGEDNATFVINLSKTLAVETQLR---VLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEW 425
            |.||||                ....|:|   |..:.||    ...::..||   |.|:.::..|
  Rat   282 LLFDSD----------------KWSLQIRKKGVPTAADF----PHAIRIWYK---TKPEGQSVTW 323

  Fly   426 --------MISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFI 482
                    .:.|..||::.|..|||.:.|...:.:..::.....|.:.:|....:.....|.|::
  Rat   324 TSDQDGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEKSAKPTPLREGYM 388

  Fly   483 RDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWT-------------------RPQF 528
            ...:..|..||.                   |..|..|..||                   ||..
  Rat   389 SWHYYVTMPMPA-------------------STFTIAVGCWTEMKPKTSPLDDLTEHTLPLRPSD 434

  Fly   529 VGM------THYAY--------KMVRKFLPYYEDFFG---IKNKLPKIDLVSVPDFGFAAMENWG 576
            ...      :|..|        ...:..:||  ..|.   ::....:..|..:|....||....|
  Rat   435 ADFRYGNTCSHMEYPCRFQSASAATQNIIPY--RVFAPVCLEGACREALLWLIPSCLSAAHSVLG 497

  Fly   577 LITF-RDSALLVPEDL-QLASSSEHM-----QVVAGI-------IAHELAHQWFGNLVTPKWWDD 627
            ...| |...|:||.:. .|..:|.|:     ..:.|.       :.||:||.|||..:..:.|.:
  Rat   498 THPFSRLDILIVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHAWFGLAIGARDWTE 562

  Fly   628 LWLKEGFACYMS------------YKALE-----------HAHPEFQSMDTLTMLEFKESMEHDA 669
            .||.||||.::.            ::|||           ....|.|:..     |..:.:..:.
  Rat   563 EWLSEGFATHLEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSP-----EGMQVLRPNK 622

  Fly   670 DNTSHAISFD---VRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGN-- 729
            :.|.|..:..   |::..:..:.|..:.|.||..|||.|...:|:..:....|..:..| :|.
  Rat   623 EKTGHVSASGASVVKNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLF-HGQLI 686

  Fly   730 MDRDDLWAMLTRHGHEQGTLPKD----LSVKQIMDSWITQPGYP-VVNVERRGAD 779
            :.:|.|..:|.       ::|::    |||:.|:..|:..||.| .:..||:..|
  Rat   687 LSQDFLQMLLE-------SIPENKRFGLSVENIVGDWLECPGIPKALQEERKAKD 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	91/485 (19%)
		M1_APN_2	297..769	CDD:189008	112/562 (20%)
		ERAP1_C	846..1138	CDD:288671
Aopep	XP_008769651.1	GluZincin	250..697	CDD:301352	98/496 (20%)
Aopep	XP_008769651.1	Leuk-A4-hydro_C	743..884	CDD:286244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840