Protein Alignment CG46339 and ANPEP

DIOPT Version :9

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 1061
• Identity: 322/1061 - (30%)
• Similarity: 515/1061 - (48%)
• Gaps: 155/1061 - (14%)

  Fly   151 GVYVSKACLIIAAFITVLALLFTIAITYFVTRQGLNPKEVTPPSCITADHPDVNATPIQTAGWVS 215
            |.|:||:..|:...:.|.|:...||::...:::               .:.:.|::|:
Human     4 GFYISKSLGILGILLGVAAVCTIIALSVVYSQE---------------KNKNANSSPV------- 46

  Fly   216 MNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDNT 280
                     |:.||.||.| || |...|||                                 :.
Human    47 ---------ASTTPSASAT-TN-PASATTL---------------------------------DQ 67

  Fly   281 TKPINRPLKLYEGWRPLHYSLLIEPSVATS-----ISNGSLTIEIERDVSKVTSWEPIVLDVH-- 338
            :|..|| .:|....:|..|.:.:.|.:..:     :..||.|:..  ...:.|.    |:.:|
Human    68 SKAWNR-YRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRF--TCKEATD----VIIIHSK 125

  Fly   339 --NVSISNVR--VIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDF 399
              |.::|...  |:|.:     ..|:..|:| .::..|.....|::|..:|..::|..  :..:|
Human   126 KLNYTLSQGHRVVLRGV-----GGSQPPDID-KTELVEPTEYLVVHLKGSLVKDSQYE--MDSEF 182

  Fly   400 VSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKM 464
            ..::.|.|.|.|::.|...:.:  :.:.:||....|||::|||||.|.|||.|:|:::.|... .
Human   183 EGELADDLAGFYRSEYMEGNVR--KVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDL-T 244

  Fly   465 ALSNM-PKSGSRRFRR--GFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRP 526
            ||||| ||..|.....  .:...:|.|||||.|||:|||||.. |.......:|:.  :.||.||
Human   245 ALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEF-DYVEKQASNGVL--IRIWARP 306

  Fly   527 QFVGMTH--YAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPE 589
            ..:...|  ||..:....|.::...:.....|||.|.:.:|||...|||||||:|:|:::||..
Human   307 SAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFD- 370

  Fly   590 DLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMD 654
              .|:|||.:.:.|..:|||||||||||||||.:||:||||.||||.|:.|...::|.|.:...|
Human   371 --PLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKD 433

  Fly   655 TLTMLEFKESMEHDADNTSHAIS---FDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRS 716
            .:.:.:....|..||..:||.:|   .::.:...:..:||.||||||..:||||:|.:.:..|:.
Human   434 LMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQ 498

  Fly   717 ATRDLLKKFAYGNMDRDDLWAMLTRHGHEQG-TLPKDLSVKQIMDSWITQPGYPVVNVERRGADL 780
            .....|..|||.|....:||..|....:.:. .||  .:|:.||:.|..|.|:||:.|:....
Human   499 GLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLP--TTVRDIMNRWTLQMGFPVITVDTSTG-- 559

  Fly   781 VLRQERYLL-PSKNTADQS----TWFIPITFETDELRKGDNIPTHWM---RSEDEEELIVGNVFA 837
            .|.||.:|| |..|....|    .|.:|||    .:|.|.....:|:   |::::       :|:
Human   560 TLSQEHFLLDPDSNVTRPSEFNYVWIVPIT----SIRDGRQQQDYWLIDVRAQND-------LFS 613

  Fly   838 HSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTLPRITRAQLLDDALHLSQAEYLTY 898
            .|.|  ..:.||||..||||||||..:|    ..|:::.|.:|.|.|||:::||.:|:.|    :
Human   614 TSGN--EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASA----H 672

  Fly   899 DIPLTFLME--LFDAVDDELL-WIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHE 960
            .:|:|..:.  ||...:.:.: |.||...|:|......|...|...:.::|..|.|.|.|:..:.
Human   673 KVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNT 737

  Fly   961 ------PDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTS 1019
                  |:|......:..|:..  ||......|.:.....|::||.:|.||||.|||:|.:||.:
Human   738 NNWREIPENLMDQYSEVNAIST--ACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNA 800

  Fly  1020 LAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFR 1084
            :|:|...||.||::|::..|..:|.:::..:|.|:.:.|:|::||:.|:||.. |.|||......
Human   801 IAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDL-IRKQDATSTII 864

  Fly  1085 AVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLG 1149
            ::.:|.||..:.:||:|.|.|::...||.|..:.|.:|:::|...:.:|...||........:.|
Human   865 SITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETG 929

  Fly  1150 LHAVESAIELALEQVNNNIYW 1170
            ..:...|:|.|||:...||.|
Human   930 FGSGTRALEQALEKTKANIKW 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	141/420 (34%)
		M1_APN_2	297..769	CDD:189008	164/491 (33%)
		ERAP1_C	846..1138	CDD:288671	97/304 (32%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		14/100 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62		11/39 (28%)
		Metalloprotease	69..967		299/930 (32%)
		M1_APN-Q_like	84..545	CDD:341064	162/485 (33%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		1/6 (17%)
		Substrate binding. /evidence=ECO:0000269|PubMed:22932899	352..356		2/3 (67%)
		ERAP1_C	619..946	CDD:403137	105/333 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850