DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and Trhde

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	953	Identity:	288/953 - (30%)
Similarity:	467/953 - (49%)	Gaps:	113/953 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 PVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIE-RDVSKVTSW 330
            |..:|.: |.|....:|..: |:|....:||||:|::...:.....:|.:.:||. |:.::.
Mouse   162 PSAQPPS-EEEREQWQPWTQ-LRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRY--- 221

  Fly   331 EPIVLDVHNVSISNVRVIRALADGASNAS------EEQDLDFDSDYGEDNATFVINLSKTLAVET 389
              :||....|::..|:|....|.||...:      :.|.|             |:.|::||  :.
Mouse   222 --VVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVL-------------VVVLNRTL--DA 269

  Fly   390 QLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSI 454
            |....|.:.:.:.:.:.|.|.:::||.....:  .::..|||||..||:||||||.|..||.|.|
Mouse   270 QRHYNLKIIYNALIENELLGFFRSSYVIHGER--RFLGVTQFSPTHARKAFPCFDEPIYKATFKI 332

  Fly   455 SIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPR 519
            ||.....: ::|||||...|.....|::.|.|..||.|.||.:|:.:.|.. .|..:..||:.
Mouse   333 SIKHQATY-LSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFT-YRETTTKSGVV-- 393

  Fly   520 VEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRD 582
            |.::.||..:  |...||..:.::.:.:|||:|.:...|||:||::||...:||||||||..|.:
Mouse   394 VRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVE 458

  Fly   583 SALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAH 647
            ..:|:...:   ||..::..|..:|.||:.|||||:||||.||:|:|||||||.|..:...::.:
Mouse   459 QRILLDPSV---SSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLY 520

  Fly   648 PEFQSMDTLTMLE--FKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVG 710
            |.: :|:....|.  ..|.|..|...:||.:|.:|....|:.|:||.|:|.||..|:|||.:.:|
Mouse   521 PAW-NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMG 584

  Fly   711 DVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNV-- 773
            ...|:...:|.|....|||..|:|||..|:......|   |.::::::||.|..|.||||:.:
Mouse   585 HSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALRRNG---KYVNIQEVMDQWTLQMGYPVITILG 646

  Fly   774 ----ERRGADLVLRQERYL--LPSKNTADQ-----STWFIPITFETDELRKGDNIPTHWMRSEDE 827
                |.|   :::.|:.::  :.:|..|.|     ..|.||:|.....            ||...
Mouse   647 NTTAENR---ILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGN------------RSHVS 696

  Fly   828 EELIVGNVFAHSSNSDNVIYL--------NLNRQGYYRVNYDMTSWL----ALKKNFSTLPRITR 880
            .|.|:.  .::.|....:.||        |:|:.||:|||||:.:|.    .|.:|...|....|
Mouse   697 SEAIIW--VSNKSEHHRIAYLDRGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNR 759

  Fly   881 AQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLIYNLKREPAYETFRAFM 945
            |.|:|||..|::|.||..:|||..:..|.:. .|.|.|.||...|..|...|.|   .|.:..|.
Mouse   760 AALIDDAFSLARAGYLPQNIPLEIIRYLSEE-KDFLPWHAASRALYPLDKLLDR---MENYNIFN 820

  Fly   946 KFIVRP-AFDHYGLHEPDNE----------SHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWM 999
            ::|::. |..:..|..|.|.          .|.:|:...::  .||.|....|.|:|.....:|:
Mouse   821 EYILKQVATTYIKLGWPRNNFNGSLVQASYQHEELRREVIM--LACSFGNKHCHQQASTLISDWI 883

  Fly  1000 RDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYL 1064
            ...:|. |..|::.::|||.::......|.|.:.::.:||:.|||:.:|.:|.|:....|||:.|
Mouse   884 SSNRNR-IPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLL 947

  Fly  1065 NMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYM 1129
            |:::| :..:|.||.......||.|..|.::|:.|.:...|.:...||:.....|::|..:|.::
Mouse   948 NLSLN-SEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFL 1011

  Fly  1130 NKDYHKHQLLDLAATCRKLGLHAVESA-IELALEQVNNNIYWR 1171
            |.:....:|.:...:     ...|.|| ...|:|.|..|:.|:
Mouse  1012 NTEGELKELKNFMKS-----YDGVASASFSRAVETVEANVRWK 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	137/412 (33%)
		M1_APN_2	297..769	CDD:189008	161/482 (33%)
		ERAP1_C	846..1138	CDD:288671	92/314 (29%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	159/477 (33%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	97/336 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950