DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and LVRN

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	1066	Identity:	308/1066 - (28%)
Similarity:	489/1066 - (45%)	Gaps:	163/1066 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GPP--SGVYVSKA-CLIIAAFITVLAL-LFTIAITYFVTRQGLNPKEVTPPSCITADHP---DVN 204
            |||  ||.|||:| .|::|..:..|.| |..:|..|       ...|..|||    :.|   |:.
Human     2 GPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALY-------GHCERVPPS----ELPGLRDLE 55

  Fly   205 ATPIQTAGWVSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVV 269
            |           .|.|||:       ..||||..|:....||:
Human    56 A-----------ESSPPLR-------QKPTPTPKPSSARELAV---------------------- 80

  Fly   270 EPAAGEVEDNTTKPIN-RP------LKLYEGWRPLHYSLLIEPSV-ATSISNGSL--TIEIERDV 324
                      ||.|.| ||      |:|.....||||.|.:.|.: ...:..|||  |..:...|
Human    81 ----------TTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITV 135

  Fly   325 SKVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVET 389
            ....:...::|...........|...|:.|..||:..:....|..:..|....|:.||:.|...:
Human   136 RCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGS 200

  Fly   390 QLRVLLSLDFVSQVTDTL-QGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFS 453
            ...  |.|.|...|.:.| :|::...||  |......::::|..|..||..|||||.|.:||.|:
Human   201 SYE--LQLSFSGLVKEDLREGLFLNVYT--DQGERRALLASQLEPTFARYVFPCFDEPALKATFN 261

  Fly   454 ISIVRPMQFKMALSNMPKSGSRRFRRGFIRDD----------FETTPKMPTYLVAFIVSNMVDSR 508
            |:::....: :|||||||.|...      ::|          |.|||.||||||||::.:.  ..
Human   262 ITMIHHPSY-VALSNMPKLGQSE------KEDVNGSKWTVTTFSTTPHMPTYLVAFVICDY--DH 317

  Fly   509 LASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAA 571
            :...:.|  ..:.||.|...:  |...:|..:......:.||.|.|...|||.|::::|.|...|
Human   318 VNRTERG--KEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHA 380

  Fly   572 MENWGLITFRDSALLV-PEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFA 635
            ||||||:.|.:|.||: |:| ||   :|...:::.:::||:.|||||||||..||:::||.||||
Human   381 MENWGLMIFDESGLLLEPKD-QL---TEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFA 441

  Fly   636 CYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRS--TNDVRRIFDPISYSKG 698
            .|..::.:.:.:|:....:..........:..|....:.|::..|.:  |::::.:||..:||||
Human   442 SYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506

  Fly   699 TILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWI 763
            ..:.|||:..:.:..|.||.:..||.|:|.|.::||||........:|.|:....::|.|||||.
Human   507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWT 571

  Fly   764 TQPGYPVV--NVERRGADLVLRQERYLLPS-KN---TADQSTWFIPITFETDELRKGDNIPTHWM 822
            .|.|:||:  ||...    |::||.:.|.: ||   .....||.:||.:    ::.|...|..|:
Human   572 HQSGFPVITLNVSTG----VMKQEPFYLENIKNRTLLTSNDTWIVPILW----IKNGTTQPLVWL 628

  Fly   823 RSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTLPRITRAQL 883
               |:...:...:....|:.|.|| ||||..||||||||...|    ..|:|:...:|.|.|.||
Human   629 ---DQSSKVFPEMQVSDSDHDWVI-LNLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQL 689

  Fly   884 LDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL-WIAAKPGLNYLIYNLKRE-PAYETFRAFMK 946
            :|||..||:..|:..:..|.....|  |.:||:: |....  :|.:..:|..| ..|:.:....:
Human   690 IDDAFSLSKNNYIEIETALELTKYL--AEEDEIIVWHTVL--VNLVTRDLVSEVNIYDIYSLLKR 750

  Fly   947 FIVRP---AFDHYGLHEPDNESHLQLKHRALVA-----YFACKFNYDRCTQKAQMKFREWMRDPK 1003
            ::::.   .::.|.....:|...||..:.||::     ..||....:.|.|.::..|.:|:..|:
Human   751 YLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPE 815

  Fly  1004 NNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTI 1068
            |....| :|.|:.|..:|.||..||......|..||:..||.::..::.|:..||:|::|:...|
Human   816 NEIPYP-IKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAI 879

  Fly  1069 NPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGD----------GFSTLSEM-I 1122
            : ||.....:..: ...|||:.:|..:|.|||..|.:.:.:.||.          |.:..::: |
Human   880 S-TSPFTSNETNI-IEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQI 942

  Fly  1123 KSLTIYMNKDYHKHQLLDLAATCRKL 1148
            ..|..:.:....:||.:.:.|..:.:
Human   943 VELQQFFSNMLEEHQRIRVHANLQTI 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	128/420 (30%)
		M1_APN_2	297..769	CDD:189008	154/490 (31%)
		ERAP1_C	846..1138	CDD:288671	88/316 (28%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		20/92 (22%)
		Peptidase_M1	97..506	CDD:279741	129/427 (30%)
		M1_APN_2	105..577	CDD:189008	154/490 (31%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	88/310 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850