DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and ENPEP

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	987	Identity:	293/987 - (29%)
Similarity:	477/987 - (48%)	Gaps:	114/987 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDI-PVVEPAAGEVEDNTTKPINRPLKLYE 292
            |..:|.|::.|:.|.:.:.|.:.::           || |..|..:|:.::         .:|.:
Human    51 PGTAPAPSHLPSSTASPSGPPAQDQ-----------DICPASEDESGQWKN---------FRLPD 95

  Fly   293 GWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASN 357
            ...|:||.|.::|.:......|:::|.|.........|    |.:....|:.:..::..:
Human    96 FVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLW----LHLRETRITRLPELKRPS----- 151

  Fly   358 ASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRV---------LLSLDFVSQVTDTLQGIYKT 413
                      .|..:....|.....:.:.||.:..:         ||:::|...:..:|.|.|:|
Human   152 ----------GDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRT 206

  Fly   414 SYT-NPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRF 477
            :|| |...|:   :::|...|.|||::|||||.|:.||.::|||..|.::. ||||||.:.....
Human   207 TYTENGQVKS---IVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYG-ALSNMPVAKEESV 267

  Fly   478 RRGFIRDDFETTPKMPTYLVAFIVSNMVDS--RLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVR 540
            ...:.|..||.:..|.||||.|.| :..||  |:::....||    |:.:|:......||..:.:
Human   268 DDKWTRTTFEKSVPMSTYLVCFAV-HQFDSVKRISNSGKPLT----IYVQPEQKHTAEYAANITK 327

  Fly   541 KFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLV-PEDLQLASSSEHMQVVA 604
            ....|:|::|.:...|||:|.:::||||..|||||||||:|::.||. |::    |:|.:.|.||
Human   328 SVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKE----SASSNQQRVA 388

  Fly   605 GIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDA 669
            .::||||.||||||:||..||:||||.||||.:..:..:.||..::|..|.:.:.:.....|.|:
Human   389 TVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDS 453

  Fly   670 DNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDD 734
            ..:||.|...|.:.:::..:||.||||||:.:||||...:....|:...:..|:|:.:.|....|
Human   454 LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSD 518

  Fly   735 LWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLL-----PSKNT 794
            .||.|    .|...||    ||::||:|..|.||||:||  .|...: .|:|:||     ||:..
Human   519 FWAAL----EEASRLP----VKEVMDTWTRQMGYPVLNV--NGVKNI-TQKRFLLDPRANPSQPP 572

  Fly   795 ADQS-TWFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQ--GYY 856
            :|.. ||.||:.:..      |||.:..:.:..|:|.|..|    |||.....:|.:|..  |:|
Human   573 SDLGYTWNIPVKWTE------DNITSSVLFNRSEKEGITLN----SSNPSGNAFLKINPDHIGFY 627

  Fly   857 RVNYDMTSW----LALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL 917
            ||||::.:|    .||..|..|.....||.|:|||..|::|:.|.|.:.|. |.:.....::.|.
Human   628 RVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALN-LTKYLKREENFLP 691

  Fly   918 WIAAKPGLNYLIYNLKRE-PAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACK 981
            |......:.|:|...:.: ..|.....:.:..|:|..|..|.:  |...|:....|:.|..||||
Human   692 WQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWN--DAGDHVTKLLRSSVLGFACK 754

  Fly   982 FNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLA-EGSSPEWYFAYKQYKTTTSASEKE 1045
            .........|...|.:|:....:.|:  ||:.::|...:. .|:...|.:..:||:.|:.|.|||
Human   755 MGDREALNNASSLFEQWLNGTVSLPV--NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817

  Fly  1046 EILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEY 1110
            ::|..|.......|||:||:: :..|:.|..||.....|.::.|:.|..:|::::|.|...:|..
Human   818 KLLYGLASVKNVTLLSRYLDL-LKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNR 881

  Fly  1111 YGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSY 1175
            |......|..:: ::....|.:....|:....|...:.|  |.|...|..||.|.|||.|.....
Human   882 YTLNNRNLGRIV-TIAEPFNTELQLWQMESFFAKYPQAG--AGEKPREQVLETVKNNIEWLKQHR 943

  Fly  1176 HSLK----NFLE 1183
            ::::    |.||
Human   944 NTIREWFFNLLE 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	135/414 (33%)
		M1_APN_2	297..769	CDD:189008	158/484 (33%)
		ERAP1_C	846..1138	CDD:288671	79/299 (26%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83		9/42 (21%)
		Peptidase_M1	92..482	CDD:279741	136/421 (32%)
		M1_APN_2	100..545	CDD:189008	158/484 (33%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		2/3 (67%)
		ERAP1_C	617..931	CDD:288671	86/322 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870