Protein Alignment CG46339 and Y67D8C.9

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001122826.1
• Gene: Y67D8C.9 / 177088
• WormBaseID: WBGene00022073
• Length: 1144
• Species: Caenorhabditis elegans
• Alignment Length: 1267
• Identity: 286/1267 - (22%)
• Similarity: 476/1267 - (37%)
• Gaps: 361/1267 - (28%)

  Fly   140 GQKYVFNGPPSGVYV-------------SKACL--IIAAFITVLALLFTIAITYFVTR------- 182
            |:..:.||..:...|             ::.|:  |:...|.:||:|..:.|.::::.
 Worm    14 GEPCIRNGSGAAATVHFRQESRRRKSDFARKCIAVILLHAIFLLAILAALIIGHWISEENQKLSN 78

  Fly   183 --------------QGLNPKEVTPPSCITADHPDVNATPIQTAGWVSMNSPP-------PLQAAT 226
                          :|:.......|..::..|..:..|.....|.....:||       ||:
 Worm    79 RTMLNITLAEAYLLEGIYTTSTATPESLSHHHTHLLTTSSAALGQSKKKTPPRVVERLIPLE--- 140

  Fly   227 PTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPA-AGEVEDNTTKPINRPLKL 290
                    .....|::.....||.             |...:.|.. |......:|..:..||.|
 Worm   141 --------KKRNFTISDVFPPPAD-------------GGFGIAEQLHAVRANKLSTDALLVPLPL 184

  Fly   291 YEGWRPLHYSLLIEPSVATS--ISNGSLTIEIERDVSKVTSWEPIVLDVH---NVSISNVRVIRA 350
            |  ..|.||.|.::.|...:  ....:::|.:|   |...|.|. .:..|   |:.:..:|:.:
 Worm   185 Y--ILPYHYDLQLDFSQFDTHLFIRANISIHLE---SYGNSTED-EIQFHLGPNIKMERMRLRK- 242

  Fly   351 LADGASNASEEQDLDFDSDYGE-------DNATFVINL--SKTLAVETQLRVLLSLDFVSQVTDT 406
              ||....::....:.....|.       ....:::.:  :.|:..|....|..|||  :|...:
 Worm   243 --DGKKFYAKTFKREESKKLGRISLRDPLQKGKYILEMTYNMTICDEDVDGVRCSLD--NQTNSS 303

  Fly   407 LQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMP- 470
            |:.   ||:|            |:|.|..||..|||:|.|.:||.|:||:....::.: |||||
 Worm   304 LKA---TSFT------------TKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTV-LSNMPP 352

  Fly   471 ------KSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFV 529
                  ||...:|:...    |:|||.|.|||:||.:...|  :|.|:.....| |.:||.|:.|
 Worm   353 VESHDHKSWEDQFKTTV----FQTTPPMSTYLLAFAIGEFV--KLESRTERGIP-VTVWTYPEDV 410

  Fly   530 GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLA 594
            ....:..:.........||...|...|||:||::..:|....||||||:.|..:::.....:
 Worm   411 MSMKFTLEYAPVIFDRLEDALEIPYPLPKVDLIAARNFHVGGMENWGLVVFEFASIAYTPPI--- 472

  Fly   595 SSSEHMQV----------VAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHP- 648
              ::|:..          :..:||||.||||||||||.:.|.:|:|.||||.:..|:.:....|
 Worm   473 --TDHVNETVDRMYNEFRIGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPV 535

  Fly   649 --EFQSMDTLTMLEFKESMEHDADNTSHAISF--DVRSTNDVRRIFDPIS-YSKGTILLRMLNSI 708
              :|:..|:|..|...:|.|      .|.:|.  ::.:.:.|...|.|.: |:||.:|:|||..:
 Worm   536 TAQFEYYDSLASLILAQSEE------DHRLSLVRELATESQVESSFHPTNLYTKGCVLIRMLRDL 594

  Fly   709 VGDVAFRSATRDLLKKFAYGNMDRDDLWAML---TRHGHEQGTLPKDLSVKQIMDSWITQPGYPV 770
            |.|..|::|.|..|:|.||.::.||||:|.|   ..||.||..|      ..:::.|....|.|.
 Worm   595 VSDFDFKAAVRRYLRKNAYRSVSRDDLFASLPAYADHGAEQEKL------SHVLEGWFVNEGIPE 653

  Fly   771 VNVERR-----------------------------------------GADL-------------- 780
            :.:.|.                                         |:.|
 Worm   654 ITLIRNYDNEMMTISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKK 718

  Fly   781 ---------------------VLRQERYLLPSKNTADQSTWFIPITFETDELR--KGDNIPTHWM 822
                                 :.|::....|.:..|.|..|.||||:....|:  :|..|...|:
 Worm   719 DRRRKHRPIRRKTSTPPSISPISRRDELRKPRRVGASQDLWTIPITYMFGSLKTSEGQVIREFWL 783

  Fly   823 RSEDEEELIVGNVFAHSSNSDN-VIYLNLNRQGYYRVNYDMTSW--LA--LKKNFSTLPRITRAQ 882
            ::....       |..:..|.| .:.:|...:..||||||:.:|  ||  |.:|...:...:|.|
 Worm   784 KNRTVS-------FGDAEISPNQAVLVNPEWKYPYRVNYDLLNWKLLARTLHQNHLEINEKSRMQ 841

  Fly   883 LLDDALHLSQAEYLTYDIPLTFLMELFDAVDDEL-LWIAAKPGLNYLIYNLKREPAYETFRAFMK 946
            |:.|      |||.           |.::|:..| |::     |.||.:..|.|.......|..|
 Worm   842 LILD------AEYF-----------LSNSVNPHLYLYL-----LGYLAHETKMEVMLFGIDAVYK 884

  Fly   947 FIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFN-YDRCTQKAQMKFRE---WMRDPKNNPI 1007
            ||             |.....|| ::|::.||....: .|....::|:....   |:       :
 Worm   885 FI-------------DVYKATQL-NKAILVYFEPVISQMDHLLNESQVDAETASLWL-------V 928

  Fly  1008 KPNLKSVIYCTSLAEG---------------SSPEW-YFAYKQY---------KTTTSASEKEEI 1047
            :|...:.:|....|.|               |..|| ...:||.         .|.......:::
 Worm   929 RPERLAKLYQMRCAAGLSSCKNDYYTQRWSRSPDEWTEDVHKQVTAVCHQLFTNTPDEVKTVQDL 993

  Fly  1048 LTS-LGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVAS--NAIGHEIAFDFLQGNIKEIVE 1109
            |.| |..:...|.|:..| ...:....:|::..    ||:.|  ||:.:..|   ||.:..   .
 Worm   994 LDSRLQSSGAKWALTVQL-AACSHDQKLLRRTA----RAIVSTKNAVVYASA---LQSDFS---L 1047

  Fly  1110 YYGDGFSTL--SEMIKSLTIYMNKDYHKHQLLDLAAT----CRKLGLHAVESAIELALEQVNNNI 1168
            :|...|...  :|:.|..|      :.|..|....:|    ..::.||:|::..|  |:|:...:
 Worm  1048 HYNPTFRKYLWAEIAKMST------FEKTALFSTNSTDILPASRILLHSVKTIDE--LQQIRGLL 1104

  Fly  1169 -YW---RSHSYHSLKNFL-------EGIVSEF 1189
             .|   .|..:..|:.:|       :|::.:|
 Worm  1105 TNWGPLLSLHFEYLERYLLWVSSVSQGVLHQF 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	147/506 (29%)
		ERAP1_C	846..1126	CDD:463368	70/318 (22%)
Y67D8C.9	NP_001122826.1	M1_APN-Q_like	190..645	CDD:341064	146/503 (29%)