DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and Y53F4B.20

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_497105.3	Gene:	Y53F4B.20 / 175160	WormBaseID:	WBGene00013166	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	807	Identity:	164/807 - (20%)
Similarity:	284/807 - (35%)	Gaps:	211/807 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 DNTTKPINRPLK------------------LYEGWRPLHYSL--LIEPSVATSISNGSLTIEIER 322
            |:...||.:||.                  |:.|...:|:.:  .|.|..|....:.|....|:.
Worm    29 DDRLPPILKPLSYDLQLQLPLSEVSDPDVPLFTGRCVMHFEINQQIGPESAFISDSTSNRARIKF 93

  Fly   323 DVSKVTSWE--PIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTL 385
            |:..:..:|  .:|::.|.:.|.||:    |.|.:...|.:|.:.|...|             ||
Worm    94 DIIMLDHFENVSLVMNGHELEIFNVQ----LTDDSMELSVDQPVLFPGRY-------------TL 141

  Fly   386 AVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKA 450
            .:.                 ..:|:..::....|. .|..:..:...|..|...||.:.....|.
Worm   142 TIH-----------------RYKGLIGSAIYYRDA-GEHAVFGSNLFPNRAPAVFPSYLASTEKV 188

  Fly   451 NFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSG 515
            .|||::|.|:......|...:...|:....:....|.|||.:...::.|::.....:.:.|..:|
Worm   189 TFSITMVHPVGTLALTSGSNEGAPRKIDENWQMTTFSTTPSITPSMLCFLLLPHEYTHIESTYTG 253

  Fly   516 LTPRVEIWTRPQFVGMTHYAYKMVRK------------FLPYYEDFFGIKNKLPKIDLVSVPDFG 568
            :...|            ||....|:|            .|...:|.|.....:||||::::.:..
Worm   254 VNISV------------HYNRFRVQKEQTKHLLHTATQVLALLKDIFSSLIPVPKIDIITMNEVS 306

  Fly   569 FAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEG 633
            ..|.  :|.|        |..::|..|:....||  .::|..||.||.|.........:|.|:|.
Worm   307 STAC--FGSI--------VVSEVQFFSADYANQV--KMLATWLAKQWIGGYAAISEGSELCLQED 359

  Fly   634 FACYMSYKALEH-AHPEFQSMDTLTMLEFKESMEHDADN---TSHAISFDVRSTNDVRRIFDPIS 694
            ...:::.|.::. .:.||..:..|..:...|::....|.   ..|...|:         ||:...
Worm   360 LVAFIADKVIKRMTNDEFTRLGHLAKIYLSETIFTAGDTLKLDEHPNEFE---------IFEKCG 415

  Fly   695 YSKGTILLRMLNSIVGDVAFRSATRDLL---KKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVK 756
            . ||..:|..:.|::|:.:..|...:::   ||.:|.:.         |.:|....|:.:|:.|.
Worm   416 L-KGVAMLESIESLIGEKSMISKINEMIYNSKKGSYSSR---------TLYGLLNSTVDEDIYVS 470

  Fly   757 QIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTAD----QSTWFIPITFETDELRKGDNI 817
            |::..|....|.|.:||:|....:.:.|....:..||.|.    ...|.:|:.|...:|
Worm   471 QLLHYWHEHGGLPYMNVDRLANSIKITQNGSNMTVKNGAGTWERMPLWPLPLKFTEFKL------ 529

  Fly   818 PTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWLALKKNFSTLPRITRAQ 882
            |.         :::|.:....|...|.:|:.||....|||||||:.:|..:|
Worm   530 PI---------QIMVSHGIHLSPIRDGLIFSNLGFTNYYRVNYDIDTWREIK------------- 572

  Fly   883 LLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLIYNLKR--EPAYETFR-AF 944
                       ..||.:.....|.|.|..|.|...:           |::|.  |||....| .|
Worm   573 -----------TVLTENATSYTLRERFQLVSDFCYF-----------YSIKSLPEPAASVLRNEF 615

  Fly   945 MKFI-VRPA---------FDHYGLHEPDNESHL------QLKHRALVAYFACKFNYDRCTQKAQM 993
            ::.: :||.         |.....||.....||      ||:.:.          :|.....::|
Worm   616 VQLVRLRPTSFPICDAAIFQCVVTHEHTKPRHLDKSTMVQLRRKV----------FDSFANSSEM 670

  Fly   994 KFREWMRDPKNNPIKPNLKSVIYCTSL 1020
            :.|..:.....|.:         ||.|
Worm   671 ECRAGLAHDALNDL---------CTKL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	82/421 (19%)
		M1_APN_2	297..769	CDD:189008	99/494 (20%)
		ERAP1_C	846..1138	CDD:288671	42/194 (22%)
Y53F4B.20	NP_497105.3	GluZincin	39..>300	CDD:301352	58/307 (19%)
Y53F4B.20	NP_497105.3	ERAP1_C	552..>593	CDD:288671	17/64 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010