DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG46339 and Lta4h

DIOPT Version :9

Sequence 1:NP_001263001.1 Gene:CG46339 / 44359 FlyBaseID:FBgn0285963 Length:1194 Species:Drosophila melanogaster
Sequence 2:NP_032543.2 Gene:Lta4h / 16993 MGIID:96836 Length:611 Species:Mus musculus


Alignment Length:536 Identity:125/536 - (23%)
Similarity:202/536 - (37%) Gaps:131/536 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 LHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNASEE 361
            ||....::.:..|.....:||::     |:..:...:.||..:::|..| ||.         .:|
Mouse    22 LHLRCSVDFARRTLTGTAALTVQ-----SQEENLRSLTLDTKDLTIEKV-VIN---------GQE 71

  Fly   362 QDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWM 426
            .........|...:...|:|...|:...::.:.:|.:                 |:|.:...:|:
Mouse    72 VKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFE-----------------TSPKSSALQWL 119

  Fly   427 ------------ISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNM-------PKS 472
                        :.:|...:..|...||.|.|.:|..::..:..|.:....:|.:       |:.
Mouse   120 TPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPED 184

  Fly   473 GSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYK 537
            .||:..|      |.....:|.||:|.:|     ..|.|:..|  ||..:|:..:.|..:...:.
Mouse   185 PSRKIYR------FNQRVPIPCYLIALVV-----GALESRQIG--PRTLVWSEKEQVEKSANEFS 236

  Fly   538 MVRKFLPYYEDFFGIKNKLPKI----D-LVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSS 597
            .....|...||..|     |.:    | ||..|.|.:..||| ..:||....||..:        
Mouse   237 ETESMLKIAEDLGG-----PYVWGQYDLLVLPPSFPYGGMEN-PCLTFVTPTLLAGD-------- 287

  Fly   598 EHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSY--------KALEHAHP-----E 649
               :.::.:||||::|.|.|||||.|.||..||.||...|:..        :...|.|.     |
Mouse   288 ---KSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGE 349

  Fly   650 FQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDP------ISYSKGTILLRMLNSI 708
            .|:    |:..|.|         ||..:..|....||    ||      |.|.||..||..|..:
Mouse   350 LQN----TIKTFGE---------SHPFTKLVVDLKDV----DPDVAYSSIPYEKGFALLFYLEQL 397

  Fly   709 V-GDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVV- 771
            : |...|....:..:|||:|.::..||..:.|..|..::    .||..:...::|:..||.|.| 
Mouse   398 LGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDK----VDLLNQVDWNTWLYAPGLPPVK 458

  Fly   772 ---NVERRGADLVLRQ 784
               :|....|.:.|.|
Mouse   459 PNYDVTLTNACIALSQ 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG46339NP_001263001.1 Peptidase_M1 296..698 CDD:279741 99/443 (22%)
M1_APN_2 297..769 CDD:189008 119/515 (23%)
ERAP1_C 846..1138 CDD:288671
Lta4hNP_032543.2 leuko_A4_hydro 6..608 CDD:274120 125/536 (23%)
M1_LTA4H 6..450 CDD:189006 117/510 (23%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 135..137 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 267..272 0/4 (0%)
Leuk-A4-hydro_C 468..607 CDD:286244 3/7 (43%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960 564..566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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