DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and Anpep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	1063	Identity:	322/1063 - (30%)
Similarity:	506/1063 - (47%)	Gaps:	160/1063 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GVYVSKACLIIAAFITVLALLFTIAITYFVTRQGLNPKEVTPPSCITADHPDVNATPIQTAGWVS 215
            |.|:||...|:...:.|.|:...||:                 |.:.|...:.||.
Mouse     4 GFYISKTLGILGILLGVAAVCTIIAL-----------------SVVYAQEKNRNAE--------- 42

  Fly   216 MNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDNT 280
             ||     |..||   .|..|:..|.|||                          ||..|
Mouse    43 -NS-----ATAPT---LPGSTSATTATTT--------------------------PAVDE----- 67

  Fly   281 TKPINRPLKLYEGWRPLHYSLLIEPSVATS-----ISNGSLTIEIERDVSKVTSWEPIVLDVHNV 340
            :||.|: .:|.:...|..|.:::.|.:..:     |..|:.|:..  ..::.|.    |:.:|:.
Mouse    68 SKPWNQ-YRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRF--TCNQTTD----VIIIHSK 125

  Fly   341 SIS-----NVRVIRALADG--ASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLD 398
            .::     |.||:....||  |.|. ::.:|...::|      .|::|..:|....|..  :...
Mouse   126 KLNYTLKGNHRVVLRTLDGTPAPNI-DKTELVERTEY------LVVHLQGSLVEGRQYE--MDSQ 181

  Fly   399 FVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFK 463
            |..::.|.|.|.|::.|...|.|  :.:.:||....|||::|||||.|.|||.|:|:::.|...
Mouse   182 FQGELADDLAGFYRSEYMEGDVK--KVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNL- 243

  Fly   464 MALSNMPKSGSRRFRR--GFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRP 526
            :|||||....|:.:..  .....:|.:||||.|||:|:|||   :.:..|..|....::.||.||
Mouse   244 IALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVS---EFKNISSVSANGVQIGIWARP 305

  Fly   527 QFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPE 589
            ..:  |...||..:....|.::...:.....|||.|.:::|||...|||||||:|:|:|:|:.
Mouse   306 SAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVF-- 368

  Fly   590 DLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMD 654
            |.|.:|.|...:||. :|||||||||||||||..||:||||.||||.|:.|...::|.|.:...|
Mouse   369 DSQSSSISNKERVVT-VIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKD 432

  Fly   655 TLTMLEFKESMEHDADNTSHAISF---DVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRS 716
            .:.:.:....|..||..:||.:|.   ::::.:.:..:||.|:||||..::|||:|.:.:..|:.
Mouse   433 LMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKK 497

  Fly   717 ATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLV 781
            .....|..:.|.|....|||..|.:..::|..:....:|:.|||.||.|.|:||:.|.....:
Mouse   498 GLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGE-- 560

  Fly   782 LRQERYLLPSKNTADQST-----WFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSSN 841
            :.|:.:||.||:...:.:     |..||.|    |:.|.. ..:|:..|..:..    .|..|||
Mouse   561 ISQKHFLLDSKSNVTRPSEFNYIWIAPIPF----LKSGQE-DHYWLDVEKNQSA----KFQTSSN 616

  Fly   842 SDNVIYLNLNRQGYYRVNYDMTSWLALKK----NFSTLPRITRAQLLDDALHLSQAEYLTYDIPL 902
              ..|.||:|..|||.||||..:|..|:.    :.|.:|.|.|||::.|:.:|:.|:.    ||:
Mouse   617 --EWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKM----IPI 675

  Fly   903 TFLME--LFDAVDDELL-WIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHY-------- 956
            |..::  ||...:.|.: |.||...|||......|...|...:.::|..|.|.|.::
Mouse   676 TLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWV 740

  Fly   957 ----GLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYC 1017
                .|.|..||.:        ....||......|.......:.:||::|.||.|.|||:|.:||
Mouse   741 NRPPTLMEQYNEIN--------AISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYC 797

  Fly  1018 TSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALA 1082
            .::|.|...||.||::|::..|..:|.:::.::|.|:...|:|::||:.|:|| ..|.|||....
Mouse   798 NAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNP-DYIRKQDTTST 861

  Fly  1083 FRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRK 1147
            ..::|||..||.:.:||::.|.|::.|.||.|..:.:.:|:.:|...:.::...||....|....
Mouse   862 IISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSA 926

  Fly  1148 LGLHAVESAIELALEQVNNNIYW 1170
            .|......|:|.|||:...||.|
Mouse   927 TGFGTGTRALEQALEKTRANIDW 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	140/420 (33%)
		M1_APN_2	297..769	CDD:189008	162/490 (33%)
		ERAP1_C	846..1138	CDD:288671	96/310 (31%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		11/65 (17%)
		Metalloprotease	69..966		295/932 (32%)
		M1_APN-Q_like	84..545	CDD:341064	159/484 (33%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		2/3 (67%)
		ERAP1_C	618..945	CDD:403137	105/339 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850