DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and anpep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	1092	Identity:	315/1092 - (28%)
Similarity:	513/1092 - (46%)	Gaps:	176/1092 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GVYVSKACLIIAAFITVLALLFTIAITYFVTRQ-GLNPKEVTPPSCITADHPDVNATPIQTAGWV 214
            |.||||..|.:.....|.|:...||:....::: |.|.....||...|
Frog     4 GFYVSKLVLAVGIIFAVAAVSTIIALAVVYSQEKGKNNDVAKPPETTT----------------- 51

  Fly   215 SMNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDN 279
                             |.:.|:|.|.|||....|::
Frog    52 -----------------SSSGTSTATTTTTATATATA---------------------------- 71

  Fly   280 TTKPINRPLKLY---EGWRPLHYSLLIEP---------------SVATSISNGSLTIEIERDVSK 326
            ||...|.|...|   :...|:||.:.::|               |.|..|.|.:..:.|
Frog    72 TTAQSNDPWNKYRLPKTLSPVHYDVELQPFLVKNADGLYVFRGKSTAFFICNDATDLII------ 130

  Fly   327 VTSWEPIVLDVHNVSISNVR---VIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVE 388
                      :|:..:::.:   ....|.|||::.:.:...     :.:|....|:..:..|...
Frog   131 ----------IHSNKLNHTKFNSFDAKLQDGATDVALKSTF-----FQKDKQFLVVQAAANLVPG 180

  Fly   389 TQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFS 453
            .|..  |..:||.::.|.|.|.|::.|.....  .:.:.:||....|||:||||||.|.|||.|:
Frog   181 KQYG--LYTEFVGELADDLAGFYRSEYLEDGV--TKIIATTQMQAPDARKAFPCFDEPAMKATFN 241

  Fly   454 ISIVRPMQFKMALSNMPKSGSRRFRRGFIRDD--------FETTPKMPTYLVAFIVSNMVDSRLA 510
            |::.....:| |:|||     |...|..:.:|        |:.||||.:||||||||..  ..:.
Frog   242 ITLKYRQPYK-AMSNM-----REIDRSTVTEDGQQWTVSKFDKTPKMSSYLVAFIVSEF--EAVG 298

  Fly   511 SQDSGLTPRVEIWTRPQFV---GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAM 572
            ...:.....|:||.|.:.:   ....||..:.:..|.::.:::.....|||.|.|::|||...||
Frog   299 DPGNATVTGVQIWGRKKAIQDENQGEYALSVTKPILDFFAEYYRTPYPLPKSDQVALPDFSAGAM 363

  Fly   573 ENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACY 637
            |||||:|:|::|||.  |.|::|.....:||. :|||||||||||||||.:||:||||.||||.|
Frog   364 ENWGLVTYRETALLF--DDQVSSIGNKERVVT-VIAHELAHQWFGNLVTIRWWNDLWLNEGFASY 425

  Fly   638 MSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISF---DVRSTNDVRRIFDPISYSKGT 699
            :.|...:.|.|.:...|.:.:.:....|..||..:||.::.   :|.|.:::..:||.|:||||.
Frog   426 VEYLGADKAEPNWNIKDLIVLNDVHRVMAVDALASSHPLTSREDEVNSPSEISALFDSIAYSKGA 490

  Fly   700 ILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWIT 764
            .::|||:..:.:..|.......||.|.|.|....|||..|....:.|..:...|.:|.|||:|:.
Frog   491 SVIRMLSEFLTEPLFVDGLASYLKGFEYSNTVYSDLWTHLQWAVNNQTAVKLPLPIKDIMDTWVL 555

  Fly   765 QPGYPVVNVERRGADLVLRQERYLLPSKNTADQST-----WFIPITFETDELRKGDNIPTHWMRS 824
            |.|:|||.::.  |..|:.|:.:||...:...:.:     |.:||:::...  |.|||   |:::
Frog   556 QMGFPVVKIDT--ATGVVTQKHFLLDPDSVVTRPSPFDYKWKVPISYKISS--KEDNI---WLQN 613

  Fly   825 EDE--EEL-IVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWLALKKNFST----LPRITRAQ 882
            |.|  |:. |.||         :.:.:|||..||||||||..:|..|.....|    :|.|.|||
Frog   614 ESETVEDFKITGN---------DWLLVNLNVTGYYRVNYDDNNWSRLLNQLQTSHQAIPVINRAQ 669

  Fly   883 LLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLIYNLKREPAYETFRAFMKF 947
            ::|||.:|::|:.:| .|......:...|..:.:.|.||..||:|......|...:...:.:||.
Frog   670 IIDDAFNLARAKQIT-TIQALDTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKKYMKM 733

  Fly   948 IVRPAFDHYGLHEPDNESHLQLKHRALVAYF--------ACKFNYDRCTQKAQMKFREWMRDPKN 1004
            .|.|.|::: ..|..|.::..:   :|...:        ||.::.:.|.:.|...|.:||..|:.
Frog   734 QVNPLFEYF-KQETGNWTNRPV---SLTDQYCEINTLSTACSYDIEDCLKFASELFSQWMATPQQ 794

  Fly  1005 NPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTIN 1069
            |.|.|||::.:|||::|:|...||.|.:.:::.|..|.|::::..:|.|:.:||:|:::|..:::
Frog   795 NNIHPNLRTNVYCTAVAQGGEQEWNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNRFLEYSLD 859

  Fly  1070 PTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYH 1134
            ||. |.:||......:|.:|.||..:|:||::...|.:...:|:...:...:|:.:|...:.::.
Frog   860 PTM-IRRQDAVSTISSVVNNPIGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRRFSTEFE 923

  Fly  1135 KHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSLKNFLEGIV 1186
            ..|||...|..:..|......|:|.|:|:...||.|.:.:..::|.:.|..|
Frog   924 LQQLLQFKADNQNPGFGTASQALEQAIEKTKANINWVNQNKAAVKKWFEDAV 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	138/433 (32%)
		M1_APN_2	297..769	CDD:189008	161/503 (32%)
		ERAP1_C	846..1138	CDD:288671	88/303 (29%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	159/498 (32%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	97/332 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110