DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and trhde

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	935	Identity:	295/935 - (31%)
Similarity:	469/935 - (50%)	Gaps:	78/935 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 EDNTTKPINRPLKLYEGW---------RPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEP 332
            |.....|:..|.:.::.|         |||||:|::...:......|.:.:|||    .:.|...
Frog   114 EGTQRPPVKDPEEEWKPWTYLRLPTHLRPLHYNLMVTAFMNNFTFCGEVNVEIE----CLNSSRY 174

  Fly   333 IVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSL 397
            ||:..|.:::..|:|......|      |..:.....|.: |...|:.|:::|  |.|....|.:
Frog   175 IVVHAHRLTVERVQVAEDRVAG------EVKVSHYFPYPQ-NQVLVVVLNRSL--EAQKSYNLKI 230

  Fly   398 DFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQF 462
            .:.:.:.:.|.|.:::||.....:..  :..|||||:.||:||||||.|..||.|.||| |....
Frog   231 IYSAIIENELLGFFRSSYVLHGERRS--LAVTQFSPIHARKAFPCFDEPIYKATFKISI-RHQTS 292

  Fly   463 KMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQ 527
            .::|||||...|.....|::.|.|..||.|.||.:|:.|.|.......:| ||:.  |.::.||.
Frog   293 YLSLSNMPVETSVFEEGGWVTDHFSQTPLMSTYYLAWAVCNFTFKEAVTQ-SGVV--VRLYARPD 354

  Fly   528 FV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPED 590
            .:  |...||..:.::.|.:|||:|.:...|||:||::||...:||||||||..|.:..:|:...
Frog   355 AIRRGSGDYALNITKRLLEFYEDYFRVPYSLPKLDLLAVPKHPYAAMENWGLSVFVEQRILLDPS 419

  Fly   591 LQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDT 655
            :   ||..::..|..:|.||:.|||||:||||.||:|:|||||.|.|..:...::.:|.: :|:.
Frog   420 I---SSISYLLDVTMVIVHEICHQWFGDLVTPIWWEDVWLKEGLAHYFEFVGTDYLYPGW-NMEK 480

  Fly   656 LTMLE--FKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSAT 718
            ...|.  ..|.|..|...:||.:|.:|....|:.|:||.|:|.||..|:|||.:.:|...|:...
Frog   481 QRFLTDVLHEVMLLDGLASSHPVSQEVLKATDIDRVFDWIAYKKGAALIRMLANFMGHKVFQRGL 545

  Fly   719 RDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGA--DLV 781
            :|.|....|||..|:|||..||:....:|.|   |:::::||.|..|.||||:.:.|...  |::
Frog   546 QDYLTTHKYGNAARNDLWNTLTKVLKNEGKL---LNIREVMDQWTLQMGYPVITILRNDTTDDII 607

  Fly   782 -LRQERYLLP-SKNTADQ------STWFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAH 838
             :.||.:|.. .|.|.|:      |.|.||:|...............|:.::.|...|      .
Frog   608 TITQEHFLYNIDKRTRDKEFRNKSSLWQIPLTIAVGNTSHISPQAIIWVSNKSEYHRI------P 666

  Fly   839 SSNSDNVIYLNLNRQGYYRVNYDMTSWL----ALKKNFSTLPRITRAQLLDDALHLSQAEYLTYD 899
            |.:..|.:..||::.||:|||||:.:|.    .|.:|...:....||.|:|||.:|::|.|||.:
Frog   667 SLDESNWVLGNLDQIGYFRVNYDVRNWRLLTDQLMRNSEVISVSNRAALIDDAFNLARAGYLTQN 731

  Fly   900 IPLTFLMELFDAVDDELLWIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFD-HYGLHEPDN 963
            |||..:..|.:. .|.|.|.||...|..|...|.|.   |.:..|.::|::.... ::.|..|.|
Frog   732 IPLEIIRYLSEE-KDFLPWHAASRALYPLDKLLDRT---EDYSIFSEYILKQVSTMYFRLGWPTN 792

  Fly   964 --------ESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSL 1020
                    .|:...:.|..|...||.|...:|.|||.....:|:...:|. |.||::.::|||.:
Frog   793 GQNGSAVPTSYQTEELRREVIMLACSFGNKQCHQKAATMISDWISSNRNR-IPPNVRDIVYCTGV 856

  Fly  1021 AEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRA 1085
            :......|.|.:.::.::|:.|||:.:|.:|.|:....||::.||:::| :..:|.||.......
Frog   857 SLMDEDVWEFIWMKFHSSTAVSEKKILLEALTCSDNRNLLNRLLNLSLN-SEVVLDQDAIDVIIH 920

  Fly  1086 VASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGL 1150
            ||.|..|.::|:.|.:...|.:...||:.....|::|..:|.::|.:...::|.|...  :..|.
Frog   921 VARNPHGRDLAWKFFRDKWKILNARYGEALFMNSKLISGVTEFLNTEEELNELKDFIQ--QHKGG 983

  Fly  1151 HAVESAIELALEQVNNNIYWRSHSY 1175
            .||.| :..|.|.|:.|:.|: |.|
Frog   984 SAVAS-LSRATETVDANVRWQ-HLY 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	139/405 (34%)
		M1_APN_2	297..769	CDD:189008	165/475 (35%)
		ERAP1_C	846..1138	CDD:288671	90/304 (30%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	163/470 (35%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	99/333 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020