DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and lnpep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_002933474.1	Gene:	lnpep / 100216271	XenbaseID:	XB-GENE-950921	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	1137	Identity:	310/1137 - (27%)
Similarity:	497/1137 - (43%)	Gaps:	222/1137 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LVAKLRNFKLDDTKNIRKRFHFDYISKDRFLGGQLKTKNGQKYVFNGPPSGVYVSKA-------- 157
            ||..|...:||:.:.       ||.|..:.||.....::          ||:..|.|
Frog    53 LVRGLGENELDEDEE-------DYESSAKLLGMSFMNRS----------SGLRNSAANYRQVQDG 100

  Fly   158 -CLIIAAFITVLALLFTIAITYFVTRQGLNPK-EVTPPSCITADHPDVNATPIQTAG----WVSM 216
             |.:.:|...::.::..|.....||...|.|| ..|...|....||.....||.|.|    |...
Frog   101 LCPVPSARTVIVCVVVVIIAVSVVTVVYLLPKCTFTKDGCHEKKHPLELVYPIATNGKVFPWAKS 165

  Fly   217 NSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDNTT 281
            ..|                                                           |:.
Frog   166 RLP-----------------------------------------------------------NSI 171

  Fly   282 KPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVR 346
            ||:             ||.|.:.|.:.|....|  |::|:.:::  .|...|||  |:   |.:|
Frog   172 KPV-------------HYVLTLHPDMTTMYFAG--TVQIKLNIT--ASSNNIVL--HS---SGLR 214

  Fly   347 VIRALADGASNASEEQDLDFDSDYGEDNATF---VINLSKTLAVETQLRVLLSLDFVSQVTDTLQ 408
            :|:|      :.|..:....|::..| ..||   .|.|.::|....:  .||::.:.|..:.|..
Frog   215 IIKA------HVSVTEGTTMDAEVLE-YPTFEEIAIILPESLPKGKE--CLLTIQYTSNFSSTYY 270

  Fly   409 GIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSG 473
            |.||..|.  :..|:..:.:|||.|:.||:.|||||.|..|:.|.|:|:| .|..::||||||:.
Frog   271 GFYKIDYM--EKGNKRSLAATQFEPLAARKVFPCFDEPAFKSTFQINIIR-NQSMISLSNMPKAK 332

  Fly   474 SRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKM 538
            :.....|.:.|::.|:..|.||||||||.::.::...:.|:    .|.::..|:.:....||...
Frog   333 TSTMSDGLLLDEYSTSVNMSTYLVAFIVGDIKNTTQETNDT----LVSVYAVPEKMDQVKYALDS 393

  Fly   539 VRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVV 603
            ..|.|.:|.:::.|...|.|:|||::|||...|||||||||||::|||..||   :||....|.:
Frog   394 AMKLLYFYSNYYNIAYPLKKLDLVAIPDFQAGAMENWGLITFRETALLYKED---SSSVADKQSI 455

  Fly   604 AGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHD 668
            ..:|||||||||||||||.:||:||||.||||.||.|.::....||..|.::...:.| .:::.|
Frog   456 TKVIAHELAHQWFGNLVTMEWWNDLWLNEGFATYMEYVSMSSLFPELNSENSFLKMRF-TALQKD 519

  Fly   669 ADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRD 733
            :.|.||.||.|::|...:..:||.:||.||..:|.||.:.:.:..|.....:.|:...||:...|
Frog   520 SLNASHPISTDIQSPEQIEEMFDDLSYIKGASILLMLQAFLSEDVFHHCIMEYLQAHQYGSTTSD 584

  Fly   734 DLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYL---LPSKNTA 795
            .||..:      .....|:.:||.:|.:|..:.|||:|...|:|.::.::|||:|   .|...|.
Frog   585 SLWDSM------NVVTNKNPNVKNMMKTWTQKAGYPLVTALRKGEEITVQQERFLRTPSPDHATN 643

  Fly   796 DQSTWFIPITFETDELR----KGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYY 856
            ..:.|.||:|:.|.:..    :.|||   ::..|....:.|.:.|..       :..|:|..|||
Frog   644 ASTVWHIPLTYVTRKCSGIEPQCDNI---YLLKEVTGRINVSSEFPW-------VKFNVNMTGYY 698

  Fly   857 RVNYDMTSWLALKKNFSTLPRITRAQLLDD--ALHLSQAEYLTYDI---------PLTFLMELFD 910
            .|:|....|.||.|           |||.|  .||.|....|.:||         ||....||..
Frog   699 IVDYGADGWDALIK-----------QLLRDHTVLHSSDRANLIHDIFMLAGVGKVPLAKAFELLG 752

  Fly   911 AVDDELLWIAAKPGLN--YLIYN--LKR------EPAYETFRAFMKFIVRPAFDHYGLHEPDNES 965
            .:.:|.........||  |.|:.  |||      :...|.....:..::...::       |..:
Frog   753 YLANETNSAPITQALNQFYHIHGILLKRGLDELSDKVMERGLKLLSNLINQTWE-------DEGT 810

  Fly   966 HLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIY--CTSLAEGSSPEW 1028
            ..:.:.|:.:..|||......|..||...|..|..:  |..|..::..|::  ....|||    |
Frog   811 LAERELRSSLLDFACSSGLQSCVDKAMELFNIWRLN--NTRIPTDVMKVVFKVGAKTAEG----W 869

  Fly  1029 YFAYKQYKTTTSASEKEEILTSLGCTTK----PWLLSKYLNMTINPTSGILKQD---GALAFRAV 1086
            .|.:.:|.|:...:||.:||.:|..|..    .||:.:.|:      .|:::..   ..|.|  :
Frog   870 AFLWDKYTTSLYETEKRKILEALASTDNGRKLQWLMQESLD------GGLIRSQELPAVLGF--I 926

  Fly  1087 ASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLH 1151
            :..:.|:.:|::|.:.|...|.:.:..|...:..::.:.|.:.:.|.|.::::....:.:  |..
Frog   927 SKGSPGYLLAWEFAKQNWDLITQKFMPGSFPIQSIVSTTTYHFSTDTHLNEVIAFFNSTK--GKS 989

  Fly  1152 AVESAIELALEQVNNNIYWRSHSYHSLKNFLE 1183
            .....::.|:|.:..||.|..::..|||.:|:
Frog   990 REMWCVKEAVETIKFNIEWMKNNLDSLKTWLQ 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	150/404 (37%)
		M1_APN_2	297..769	CDD:189008	168/474 (35%)
		ERAP1_C	846..1138	CDD:288671	75/321 (23%)
lnpep	XP_002933474.1	M1_APN-Q_like	174..609	CDD:341064	167/482 (35%)
lnpep	XP_002933474.1	ERAP1_C	687..1003	CDD:378732	78/356 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020