DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	964	Identity:	281/964 - (29%)
Similarity:	467/964 - (48%)	Gaps:	129/964 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 TTKPINRPLKLY---EGWRPLHYSLLIEPSVATS-------ISNGSLTIEIERDVSKVTSWEPIV 334
            ||:....|.|.|   :...|.:|::.:.|.:...       ..|.|:..:..|:.      :.|:
Zfish    35 TTESHVEPWKEYRLPDTLFPHYYNITLWPRLQPDDHGLYVFTGNSSVVFKCLRET------DIII 93

  Fly   335 LDVHNVSISNVRVIRALADG------ASNASEEQDLDFDSDYGEDNATFVINLSKTLAVET---- 389
            :..:.:::::       .||      |.:.||...:         ..|::..:::.|.::.
Zfish    94 IHCNKLNLTS-------EDGYLAKLSAFSTSEVPSV---------KKTWIEEMTQYLVLQLNGKL 142

  Fly   390 ---QLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMIST-QFSPVDARRAFPCFDRPDMKA 450
               :|.||.: :||.::.|.|.|:|::.|   |...|:.:::| |..|..||:.|||||.|.|||
Zfish   143 KAGELYVLYT-EFVGELADDLAGLYRSEY---DEDGEKKIVATSQMHPTHARKTFPCFDEPAMKA 203

  Fly   451 NFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRD-------DFETTPKMPTYLVAFIVSNMVDSR 508
            .|.|:::.. :..:||||    |........|.|       .||.|..|.:||:|.:||:.  :.
Zfish   204 VFHITLIHD-RGTVALSN----GMEIENVDTIVDGQPVTVTTFEPTKIMSSYLLALVVSDY--TN 261

  Fly   509 LASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAA 571
            :.|.|..|   :.||.|.:.:  |...||..:....|.::|:::.:...|.|.|.:::|||.|.|
Zfish   262 VTSADGTL---IRIWARKKAIEDGHGDYALNITGPILKFFENYYNVPYPLSKSDQIALPDFYFGA 323

  Fly   572 MENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFAC 636
            ||||||:.:|:|.||....:   ||:.:.:..|.||||||||.|||||||.|||:::||.||||.
Zfish   324 MENWGLVMYRESNLLYDPTV---SSNANKERTATIIAHELAHMWFGNLVTLKWWNEVWLNEGFAS 385

  Fly   637 YMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISF---DVRSTNDVRRIFDPISYSKG 698
            |:||...:.|.|.:...|.:.:.:.......||..:||.:|.   |:.....:...||.:|||||
Zfish   386 YVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLSSKEEDIIKPEQIIEQFDTVSYSKG 450

  Fly   699 TILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGT-LPKDLSVKQIMDSW 762
            ..:||||:..:.:..|.......|..||..|...:|||..|....::.|| ||  ||||.|||.|
Zfish   451 ASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWDHLQTAVNKTGTVLP--LSVKVIMDRW 513

  Fly   763 ITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQST-----WFIPITFETDELRKGDNIPTHWM 822
            :.|.|:|||.|......  :.|..:||..:::..:::     |.:||               :||
Zfish   514 VLQMGFPVVTVNTTTGQ--VSQMHFLLDPESSLQRTSPFNYEWIVPI---------------NWM 561

  Fly   823 RSED--------EEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTL 875
            :|:.        |...:..::   .:.....:.||||..||||||||:.:|    ..|.:|...:
Zfish   562 KSKMVQSRFWLLERTAVYNDM---KTTGSEWVLLNLNITGYYRVNYDIGNWERLLNQLAENHKVI 623

  Fly   876 PRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDE---LLWIAAKPGLNYLIYNLKREPA 937
            ..|.|||::|||.:|::|:.    ||:|..::....:.:|   :.|.:|...|:|......:...
Zfish   624 SVINRAQIVDDAFNLARAKI----IPVTLALKTTTYLSEEREYMPWQSALNNLDYFYLMFTQTEV 684

  Fly   938 YETFRAFMKFIVRPAFDHYGLHEPD----NESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREW 998
            |...:::.|..|.|.||::.....|    ...|....::.....|||....|.|.......:::|
Zfish   685 YRLLQSYTKKQVTPLFDYFKTITEDWSDVPSGHTDQYNQVNAIRFACSTGVDECQNLTSSWYKQW 749

  Fly   999 MRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKY 1063
            |..|.:|||.|||:|.:||:::|.|.:.||.|.:..:|  .:|.|.:::::||.|.....||.:|
Zfish   750 MDQPNHNPIHPNLRSTVYCSAIATGGAEEWDFGWTMFK--NAAIEADKLMSSLACAKNQTLLKRY 812

  Fly  1064 LNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIY 1128
            |..|::| |.|.|||.......:|||..|.::|::|::...:.:...||.|....:.:|..:|..
Zfish   813 LGYTLDP-SMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTEYGVGSFNFASLISGITKT 876

  Fly  1129 MNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYWRSHSYHSLKNFL 1182
            .:.:....|||...:...::|..:..:|:|.|:|:...||.|.:.:...:.::|
Zfish   877 FSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKWVAENQEDITDWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	131/434 (30%)
		M1_APN_2	297..769	CDD:189008	159/505 (31%)
		ERAP1_C	846..1138	CDD:288671	90/302 (30%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	131/441 (30%)
		M1_APN_2	57..520	CDD:189008	159/503 (32%)
		ERAP1_C	590..911	CDD:288671	97/327 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850