Protein Alignment drl and ZAP70

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 150/677 - (22%)
• Similarity: 266/677 - (39%)
• Gaps: 184/677 - (27%)

  Fly    20 AHLNIF------LNLHEVLRLIGVSAELYYVRE--GAINDYALNFAVPVPANISDVTFTWQSLVD 76
            |||..|      ....|.|:|.|::..|:.:|:  .::..|.|:.       :.||.|
Human    94 AHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-------VHDVRF------- 144

  Fly    77 HPLP--------YSI-------------NIATSDTEVLPRPILNISRIGDVP--VEP-------- 110
            |..|        |:|             ...:.|.:.||   .|:.:..:.|  :||
Human   145 HHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLP---CNLRKPCNRPSGLEPQPGVFDCL 206

  Fly   111 ----------QTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHE 165
                      |||  .|:......|.::....||.::  ||..:..:.:....:...|.:...:.
Human   207 RDAMVRDYVRQTW--KLEGEALEQAIISQAPQVEKLI--ATTAHERMPWYHSSLTREEAERKLYS 267

  Fly   166 EYDDDDLDLLQTARKG--------HGGDI-HYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNS 221
            ....|...||:..::.        :|..: ||:...|:   |..:..||
Human   268 GAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDK---AGKYCIPE---------------- 313

  Fly   222 GGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAK---------------GPS 271
             |:|.|....|.|.|...|.||:                    ||.|               .|:
Human   314 -GTKFDTLWQLVEYLKLKADGLI--------------------YCLKEACPNSSASNASGAAAPT 357

  Fly   272 -KRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFRE---------YE--- 323
             ..|||...|     ..:|:.|::|..:          ||..|.:|.|.:.         ||
Human   358 LPAHPSTLTH-----PQRRIDTLNSDGY----------TPEPARITSPDKPRPMPMDTSVYESPY 407

  Fly   324 HEPEEFNRR---LQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQ---EVLVKTVAQHASQLQV 382
            .:|||...:   |:...:....:.|.|    ||||.:.:|.|...:   :|.:|.:.|...:...
Human   408 SDPEELKDKKLFLKRDNLLIADIELGC----GNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 468

  Fly   383 NLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVL 447
            ..:::|:.::::..:|.::.::|: .:..|...|:..|.|.  .|..||........|:.:..:|
Human   469 EEMMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELL 530

  Fly   448 MGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGD--YNSLGDGEYRPIK 510
              .|::|.|::|.....:|:|:||||.::.::...|::|..||:.|...|  |.:...|:: |:|
Human   531 --HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW-PLK 592

  Fly   511 WLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELF 575
            |.:.|.:....::..|||||:||.|||..:.|:.||.::...|:..:::.|.|:..|..||.||:
Human   593 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 657

  Fly   576 TIMAYCWASMPAERPSF----SQLQIC 598
            .:|:.||.....:||.|    .:::.|
Human   658 ALMSDCWIYKWEDRPDFLTVEQRMRAC 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	34/184 (18%)
		PTK_Ryk	336..606	CDD:270639	73/272 (27%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191	23/119 (19%)
		SH2_C-SH2_Zap70	240..343	CDD:198265	25/144 (17%)
		PTKc_Zap-70	421..689	CDD:270686	73/274 (27%)