DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and TYRO3

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_006284.2 Gene:TYRO3 / 7301 HGNCID:12446 Length:890 Species:Homo sapiens


Alignment Length:605 Identity:152/605 - (25%)
Similarity:258/605 - (42%) Gaps:151/605 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 ALNFAVPV-------PANISD-VTFTWQSLVDHPLPYSINIATSDT-------EVLPRPILNISR 102
            |.|:::.|       |:..:| |.|..:.|.....|.:::...:|:       ||:|...|    
Human   291 ATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPL---- 351

  Fly   103 IGDVPVEPQ--TWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHE 165
              :.|:.|.  :|   ::.:||:: |:||                             |...|:.
Human   352 --EGPLGPYKLSW---VQDNGTQD-ELTV-----------------------------EGTRANL 381

  Fly   166 EYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDP 230
            ...|...||:...                 .|:|........:|:|..|....|..|      .|
Human   382 TGWDPQKDLIVRV-----------------CVSNAVGCGPWSQPLVVSSHDRAGQQG------PP 423

  Fly   231 MLRENLVPPASGLVT-LIVGGILALVLV-----STLILIAY---CAKGPSKRHPSNGVHLIKTSS 286
            ..|.:.||...|::| |:....|||:|:     .|....|:   .|:|    .|:  ||.....|
Human   424 HSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARG----EPA--VHFRAARS 482

  Fly   287 FQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQE 351
            |.|             ..|..|..|..:|        ...:|...:|:::.:.:.:..|..::.:
Human   483 FNR-------------ERPERIEATLDSL--------GISDELKEKLEDVLIPEQQFTLGRMLGK 526

  Fly   352 GNFGRIYR-------GTYNDCQEVLVKTV-AQHASQLQVNLLLQESMMLYEASHPNVLSVLGISI 408
            |.||.:..       |::   .:|.||.: |...:...:...|:|:..:.|..||:|..::|:|:
Human   527 GEFGSVREAQLKQEDGSF---VKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSL 588

  Fly   409 EDYA----------TPFVLYAATGSVRNLKSFL------QDPSYARSVTTIQTVLMGSQLAMAME 457
            ...|          .||:.:.      :|.:||      ::|......|.|:.::   .:|..||
Human   589 RSRAKGRLPIPMVILPFMKHG------DLHAFLLASRIGENPFNLPLQTLIRFMV---DIACGME 644

  Fly   458 HLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHY 522
            :|.:...||:|:|||||::.:.:.|.:.|..|||.::.|||...|.....|:|||:||:|..:.|
Human   645 YLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLY 709

  Fly   523 NEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPA 587
            ...||||:|||.|||:.|.|:.|||.|:..|:.:||..|.||.||..|.::::.:|..||::.|.
Human   710 TVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPK 774

  Fly   588 ERPSFSQLQICLSEFHTQIT 607
            :||||:.|::.|.....|::
Human   775 QRPSFTCLRMELENILGQLS 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 22/120 (18%)
PTK_Ryk 336..606 CDD:270639 90/293 (31%)
TYRO3NP_006284.2 Ig1_Tyro3_like 50..136 CDD:409553
Ig strand A 50..55 CDD:409553
Ig strand B 58..67 CDD:409553
Ig strand C 73..78 CDD:409553
Ig strand C' 81..83 CDD:409553
Ig strand D 87..92 CDD:409553
Ig strand E 97..104 CDD:409553
Ig strand F 113..119 CDD:409553
Ig strand G 125..136 CDD:409553
IgI_2_Axl_Tyro3_like 140..220 CDD:409407
Ig strand A 140..143 CDD:409407
Ig strand A' 146..150 CDD:409407
Ig strand B 154..163 CDD:409407
Ig strand C 168..175 CDD:409407
Ig strand C' 177..180 CDD:409407
Ig strand E 184..195 CDD:409407
Ig strand F 198..207 CDD:409407
Ig strand G 211..220 CDD:409407
FN3 225..317 CDD:238020 7/25 (28%)
fn3 324..406 CDD:394996 21/137 (15%)
PTKc_Tyro3 508..791 CDD:270659 91/294 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..871
Blue background indicates that the domain is not in the aligned region.

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