DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drl and TEK

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:641 Identity:151/641 - (23%)
Similarity:255/641 - (39%) Gaps:194/641 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VPVPANISDVTFTWQSLVDHPLPYSINIATSDTEVLPR--PILNISRIGDV-PVEPQTWGIALKC 119
            :.||.|::.|..  .:|  ||....:..|..:|:....  ..|....:.|: |.:|:.    :|.
Human   591 IKVPGNLTSVLL--NNL--HPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPEN----IKI 647

  Fly   120 SGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGG 184
            |...::...::   ..|||..:.::..:.:|     ::.:.:..|.:....:..:.|...||...
Human   648 SNITHSSAVIS---WTILDGYSISSITIRYK-----VQGKNEDQHVDVKIKNATITQYQLKGLEP 704

  Fly   185 DIHY-VDRNDEHVVANGHQA--------PEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPA 240
            :..| ||...|:.:.:.:.|        ||.|.|         .:.||.|.              
Human   705 ETAYQVDIFAENNIGSSNPAFSHELVTLPESQAP---------ADLGGGKM-------------- 746

  Fly   241 SGLVTLIVG--GILAL-VLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIY 302
              |:..|:|  |:..| ||::.||::.                 :|.::.||             
Human   747 --LLIAILGSAGMTCLTVLLAFLIILQ-----------------LKRANVQR------------- 779

  Fly   303 VCPSTITPTYATLTRPFREYEHEPE-EFNRRLQELTVQKCR---------------VRLSCLVQE 351
                       .:.:.|:....||. :||.....|. :|.:               ::...::.|
Human   780 -----------RMAQAFQNVREEPAVQFNSGTLALN-RKVKNNPDPTIYPVLDWNDIKFQDVIGE 832

  Fly   352 GNFGRIYRGTYND---CQEVLVKTVAQHAS---------QLQVNLLLQESMMLYEASHPNVLSVL 404
            ||||::.:.....   ..:..:|.:.::||         :|:|...|        ..|||::::|
Human   833 GNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKL--------GHHPNIINLL 889

  Fly   405 G---------ISIEDYATPFVLYAATGSVRNLKSFLQ-------DPSYARSVTTIQTVLMGSQL- 452
            |         ::||        ||..|   ||..||:       ||::|.:.:|..| |...|| 
Human   890 GACEHRGYLYLAIE--------YAPHG---NLLDFLRKSRVLETDPAFAIANSTAST-LSSQQLL 942

  Fly   453 ------AMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEY----- 506
                  |..|::|.....||:|:||||.::.:....|:.|..|||          |...|     
Human   943 HFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR----------GQEVYVKKTM 997

  Fly   507 --RPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFN 569
              .|::|:::|:|..|.|...|||||:|||:||:.:||..||..:...|:...|..||||.:|.|
Human   998 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLN 1062

  Fly   570 CPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYVXPAVLKHAKTCKYNK 625
            |.||::.:|..||...|.|||||:|:.:.|:....:...||        .|..|.|
Human  1063 CDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYV--------NTTLYEK 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 19/101 (19%)
PTK_Ryk 336..606 CDD:270639 94/326 (29%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
EGF_Lam 314..>342 CDD:238012
IgI_Tie2 348..439 CDD:409556
Ig strand A 348..352 CDD:409556
Ig strand A' 358..362 CDD:409556
Ig strand B 365..374 CDD:409556
Ig strand C 382..387 CDD:409556
Ig strand C' 391..393 CDD:409556
Ig strand D 397..401 CDD:409556
Ig strand E 404..412 CDD:409556
Ig strand F 420..428 CDD:409556
Ig strand G 431..439 CDD:409556
fn3 445..520 CDD:394996
fn3 544..626 CDD:394996 9/38 (24%)
FN3 639..731 CDD:238020 17/103 (17%)
PTKc_Tie2 816..1118 CDD:133219 97/333 (29%)
Blue background indicates that the domain is not in the aligned region.

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