Protein Alignment drl and SYK

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_003168.2
• Gene: SYK / 6850
• HGNCID: 11491
• Length: 635
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 144/610 - (23%)
• Similarity: 231/610 - (37%)
• Gaps: 146/610 - (23%)

  Fly    44 VREGAINDYALNFAVPVPANISDVTFTW--------QSLVDHPLPYSINIATSDTEVLPRPILNI 100
            ::|..|.:|              |..||        |:::.........|||:..|.:|.....|
Human   123 LKENLIREY--------------VKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKI 173

  Fly   101 SRIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEV---ILDRATNNNTNLIFKRKKICLREEQDS 162
            ||                    ..:|..|.|..:.   .|.||.:||.:.     .:||..|...
Human   174 SR--------------------EESEQIVLIGSKTNGKFLIRARDNNGSY-----ALCLLHEGKV 213

  Fly   163 AHEEYDDDDLDLLQTARKGHGGDI------HYVDRNDEHVVANGHQAPEKQR----PVVTESPVG 217
            .|...|.|....| :..:|...|.      ||           .::|....|    |.......|
Human   214 LHYRIDKDKTGKL-SIPEGKKFDTLWQLVEHY-----------SYKADGLLRVLTVPCQKIGTQG 266

  Fly   218 RGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLI 282
            ..|.||.     |.|      |.|...|...|||     :|.:...::...|..|..|:.|....
Human   267 NVNFGGR-----PQL------PGSHPATWSAGGI-----ISRIKSYSFPKPGHRKSSPAQGNRQE 315

  Fly   283 KTSSF------------------QRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEF 329
            .|.||                  :.|| :.:..:.|.|..|..|.|....|.|.....|.:.
Human   316 STVSFNPYEPELAPWAADKGPQREALP-MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKE--- 376

  Fly   330 NRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQHASQLQVN------LLLQE 388
                               :..||||.:.:|.|.  .:.:|||||....:.:.|      .||.|
Human   377 -------------------LGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAE 420

  Fly   389 SMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLA 453
            :.::.:..:|.::.::||.   .|..::|......:..|..:||...:.:....|:.|   .|::
Human   421 ANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV---HQVS 479

  Fly   454 MAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGD--YNSLGDGEYRPIKWLSLEA 516
            |.|::|.....:|:|:||||.::..|...|::|..||:.|...:  |.:...|:: |:||.:.|.
Human   480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW-PVKWYAPEC 543

  Fly   517 LQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYC 581
            :....::..||||||||||||..:.|:.||..:...|:...|:.|.|:..|..||.|::.:|..|
Human   544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608

  Fly   582 WASMPAERPSFSQLQICLSEFHTQI 606
            |......||.|:.:::.|..::..:
Human   609 WTYDVENRPGFAAVELRLRNYYYDV 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	24/123 (20%)
		PTK_Ryk	336..606	CDD:270639	77/277 (28%)
SYK	NP_003168.2	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191
		Interdomain A	108..167		11/57 (19%)
		SH2_C-SH2_Syk_like	164..262	CDD:198264	27/134 (20%)
		Interdomain B	260..370		29/126 (23%)
		PTKc_Syk	375..631	CDD:133247	77/286 (27%)