Protein Alignment drl and Mertk

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_075232.1
• Gene: Mertk / 65037
• RGDID: 69283
• Length: 994
• Species: Rattus norvegicus
• Alignment Length: 664
• Identity: 172/664 - (25%)
• Similarity: 283/664 - (42%)
• Gaps: 116/664 - (17%)

  Fly     2 APNLLTI-GLLLTLIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANIS 65
            :|::||: ||..|.:.|.:||.:..|.:.:     ||...:..:.......:.||      :...
  Rat   240 SPSVLTVAGLTETAVFSCEAHNDKGLTVSK-----GVQINIKVIPSPPTEVHILN------STAH 293

  Fly    66 DVTFTWQSLVDHPLPY---SINIATSD-----------TEVLP--------RPILNIS------- 101
            .:..:|....|...|.   ||.:..:|           |...|        :.:.|.|
  Rat   294 SILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRN 358

  Fly   102 RIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEE 166
            .||...|.|  |.:|   |.|..|.....:|:.|.|:. ::||..:.:.:..|   :.||.....
  Rat   359 EIGWSAVSP--WILA---STTEGAPAVAPLNITVFLNE-SSNNLEIRWTKPPI---KRQDGELVG 414

  Fly   167 YDDDDLDLLQTARKGHGGDIHYVDRN-DEHVVANGHQAPEKQRPV--------VTESPVGRGNSG 222
            |           |..|..:.....:. .|.|..||..|   |.||        |..:.:.:|..|
  Rat   415 Y-----------RISHVWESAGTSKELSEEVSQNGSWA---QVPVQMHNATCTVRIAVITKGGIG 465

  Fly   223 GSKRDFDPML----RENLVP---PASG---LVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSN 277
            ......|..:    |.:..|   ||.|   .:.:|:|.....||:..::.::...|...:.....
  Rat   466 PFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLMGLILYLSLAIKRRVQETKFG 530

  Fly   278 GVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCR 342
            |....:.|..    .::..|..|.  |...|..|..:|        ...||...:|:::.|.:..
  Rat   531 GAFSEEDSQL----VVNYRAKKSF--CRRAIELTLQSL--------GVSEELQNKLEDVVVDRNL 581

  Fly   343 VRLSCLVQEGNFGRIYRGTYND----CQEVLVKTV-AQHASQLQVNLLLQESMMLYEASHPNVLS 402
            :.|..::.||.||.:..|....    .|:|.|||: ..:.|..::...|.|:..:.:.:||||:.
  Rat   582 LILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFNHPNVIR 646

  Fly   403 VLGISIE---------DYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVL-MGSQLAMAME 457
            :||:.||         ....||:.|   |.:.....:.:..|..:|: .:||:| ....:|..||
  Rat   647 LLGVCIELSSQGIPKPMVILPFMKY---GDLHTFLLYSRIESVPKSI-PLQTLLKFMVDIAQGME 707

  Fly   458 HLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHY 522
            :|.:...:|:|:|||||::.|.:.|.:.|..||:.::.|||...|.....|:||:::|:|....|
  Rat   708 YLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVY 772

  Fly   523 NEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPA 587
            ...||||:|||.|||:.|.|..||..:..:||..||..|:||.||.:|.|:|:.||..||::.|.
  Rat   773 TSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCWSADPL 837

  Fly   588 ERPSFSQLQICLSE 601
            :||:||.|::.|.:
  Rat   838 DRPTFSVLRLQLEK 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	31/164 (19%)
		PTK_Ryk	336..606	CDD:270639	95/281 (34%)
Mertk	NP_075232.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..77
		Ig	96..189	CDD:472250
		Ig strand B	105..109	CDD:409353
		Ig strand C	122..126	CDD:409353
		Ig strand E	153..157	CDD:409353
		Ig strand F	167..172	CDD:409353
		Ig strand G	181..184	CDD:409353
		IgI_2_Axl_Tyro3_like	193..274	CDD:409407	12/38 (32%)
		Ig strand A	193..196	CDD:409407
		Ig strand A'	199..203	CDD:409407
		Ig strand B	207..216	CDD:409407
		Ig strand C	221..228	CDD:409407
		Ig strand C'	230..233	CDD:409407
		Ig strand E	238..249	CDD:409407	3/8 (38%)
		Ig strand F	252..261	CDD:409407	3/8 (38%)
		Ig strand G	265..274	CDD:409407	3/13 (23%)
		FN3	279..373	CDD:238020	18/104 (17%)
		FN3	381..473	CDD:238020	22/109 (20%)
		PTKc_Mer	574..857	CDD:271106	95/282 (34%)