DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and RYK

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001005861.1	Gene:	RYK / 6259	HGNCID:	10481	Length:	610	Species:	Homo sapiens

Alignment Length:	652	Identity:	225/652 - (34%)
Similarity:	341/652 - (52%)	Gaps:	113/652 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PNLLTIGLLLTLIASGQA-----------------HLNIFLNLHEVLRLIGVSAELYYVREGAIN 50
            |.||.:.||..|.|.|.|                 .::::|:..||.||||:.|||||||...|:
Human    28 PLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLIS 92

  Fly    51 DYALNFAVPVPANISDVTFTW--QSLVDHPLPYSI-NIATSDTEVLPRPILNISRIGDVPVEPQT 112
            .|||:|::.||:..:.:.|||  :|.|::.|.:.: |:...|     .|.:|||..|:||.....
Human    93 HYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMD-----MPQVNISVQGEVPRTLSV 152

  Fly   113 WGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQT 177
            :.:.|.|:|..::||.:.:.:.:.:: ::.|.|.|.|||:|:|.::             |:.::|
Human   153 FRVELSCTGKVDSEVMILMQLNLTVN-SSKNFTVLNFKRRKMCYKK-------------LEEVKT 203

  Fly   178 ARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASG 242
            :.         :|:|....:                              :||:   :..|..|.
Human   204 SA---------LDKNTSRTI------------------------------YDPV---HAAPTTST 226

  Fly   243 LVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRL--PTISSTAHNSIYV-- 303
            .|..|..|:...|:....|::|.......||...:. .:..:||.|.|  |:..:|.    |:
Human   227 RVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDD-SISASSSSQGLSQPSTQTTQ----YLRA 286

  Fly   304 -CPSTITPTYATLTRPFREYEHEP------EEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGT 361
             .|:..||..::|..|....|...      .|...:::::.:.:.|:.|..::|||.||||:.|.
Human   287 DTPNNATPITSSLGYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGI 351

  Fly   362 Y------NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL--Y 418
            .      |..::..||||...||::||.::|.||..|....|.|:|.:..:.||:...|.|:  |
Human   352 LIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPY 416

  Fly   419 AATGSVRNLKSFLQ-----DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDD 478
            ...|   |||.||:     :.:..::::....|.|..|:|..|.:|....|||||:|||||||||
Human   417 MNWG---NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDD 478

  Fly   479 QLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGK 543
            .|:||:||:||||||||.||:.|||.|.||::|::||:|..:.::..||||:|||.:||:.|||:
Human   479 TLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ 543

  Fly   544 LPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITR 608
            .||.:|||:||..|||||||:|||.|||||||.:||.|||..|.|||.|.||..||:|||..:..
Human   544 TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGA 608

  Fly   609 YV 610
            ||
Human   609 YV 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	49/138 (36%)
		PTK_Ryk	336..606	CDD:270639	135/282 (48%)
		Pkinase_Tyr	343..599	CDD:285015	129/268 (48%)
RYK	NP_001005861.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		WIF	63..196	CDD:128745	49/138 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		7/27 (26%)
		PTK_Ryk	326..606	CDD:270639	135/282 (48%)
		Pkinase_Tyr	333..599	CDD:285015	129/268 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1843
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2192
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	1	1.010	-	-		QHG45854
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm41336
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830