Protein Alignment drl and Erbb4

DIOPT Version :9

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_067719.2
• Gene: Erbb4 / 59323
• RGDID: 620486
• Length: 1308
• Species: Rattus norvegicus
• Alignment Length: 566
• Identity: 136/566 - (24%)
• Similarity: 213/566 - (37%)
• Gaps: 167/566 - (29%)

  Fly   149 FKRKKICL----------RE--------EQDSAHEEYDDDDLDLLQTARKGHGGD-----IHYVD 190
            |.|.|||:          ||        |.||..|:.:|.    |.|.. |.|.|     .|:.|
  Rat   526 FSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDG----LLTCH-GPGPDNCTKCSHFKD 585

  Fly   191 -RNDEHVVANGHQA--------PEKQR------PVVTESPVGRGNSGGSKRD--FDPMLRENLVP 238
             .|......:|.|.        .::.|      |..|:     |.:|.:..|  :.|....:.:|
  Rat   586 GPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQ-----GCNGPTSHDCIYYPWTGHSTLP 645

  Fly   239 P-------ASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISST 296
            .       |:|    ::||:..||:::....:....|...|:....  ..::|...:.|
  Rat   646 QHARTPLIAAG----VIGGLFILVIMALTFAVYVRRKSIKKKRALR--RFLETELVEPL------ 698

  Fly   297 AHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGT 361
                   .||...|..|.|               |.|:|..:::.:|     :..|.||.:|:|.
  Rat   699 -------TPSGTAPNQAQL---------------RILKETELKRVKV-----LGSGAFGTVYKGI 736

  Fly   362 YNDCQEVLVKTVA----QHASQLQVNL-LLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAAT 421
            :....|.:...||    ...:..:.|: .:.|::::....||:::.:||:.:.
  Rat   737 WVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLS------------ 789

  Fly   422 GSVRNLKSFLQDPSYARSVTTIQTVL------------------MGSQL--------AMAMEHLH 460
                               .|||.|.                  :||||        |..|.:|.
  Rat   790 -------------------PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 835

  Fly   461 NHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGD---YNSLGDGEYRPIKWLSLEALQKSHY 522
            ...::|:|:||||.::.....||:||..|:| |..||   ||:  ||...||||::||.:....:
  Rat   836 ERRLVHRDLAARNVLVKSPNHVKITDFGLAR-LLEGDEKEYNA--DGGKMPIKWMALECIHYRKF 897

  Fly   523 NEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPA 587
            ...|||||:||.:||:.|.|..||..|...|:...|:.|.||.||..|..:::.:|..||.....
  Rat   898 THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDAD 962

  Fly   588 ERPSFSQLQICLSEFHTQITRYVXPAVLKHAKTCKYNKRRRRKIFQ 633
            .||.|.:|....|.......||:   |::.....|.......|.||
  Rat   963 SRPKFKELAAEFSRMARDPQRYL---VIQGDDRMKLPSPNDSKFFQ 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	5/17 (29%)
		PTK_Ryk	336..606	CDD:270639	81/303 (27%)
		Pkinase_Tyr	343..599	CDD:285015	80/289 (28%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:395817
		Furin-like	186..332	CDD:395614
		Recep_L_domain	358..478	CDD:395817
		GF_recep_IV	502..634	CDD:405525	28/117 (24%)
		TM_ErbB4	642..685	CDD:213053	9/46 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	676..684		2/7 (29%)
		PTKc_HER4	710..1012	CDD:173655	92/353 (26%)
		PPxy motif 1	1032..1035
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900