Protein Alignment drl and ryk

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_005165988.1
• Gene: ryk / 558502
• ZFINID: ZDB-GENE-070209-277
• Length: 632
• Species: Danio rerio
• Alignment Length: 663
• Identity: 222/663 - (33%)
• Similarity: 329/663 - (49%)
• Gaps: 119/663 - (17%)

  Fly     8 IGLLLTLIASG-----------------QAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALN 55
            :|..|.|:..|                 :.::|||::..||.:|:|:.|||||||:..:|.|||:
Zfish    29 VGFFLLLLLEGARCLANPSNSPGINNNNRPNVNIFMSEEEVKKLLGLDAELYYVRDDVVNHYALS 93

  Fly    56 FAVPVPANISDVTFTWQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCS 120
            |.:|||::.:.:.|||.|  ...:.|.:.....:|..:.:|..|||..|:||.....:.:.|.||
Zfish    94 FVLPVPSDTNSLHFTWHS--SSKVDYRLGFHVENTSAMDQPQSNISVQGEVPRTRSVFRVDLFCS 156

  Fly   121 GTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLRE-EQDSAHEEYDDDDLDLLQTARKGHGG 184
            |..:.|..:|:.:.:   ....|.|.|.|||:|:|.|. ||....:
Zfish   157 GKADGEAVLTVQLNL---STAANFTVLNFKRRKMCYRRIEQPEPPK------------------- 199

  Fly   185 DIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVG 249
            .:.:.:...:.:.|:...||..                 |.|.|          ..|..|..||.
Zfish   200 TLPFPNTTIQRIDASSPNAPTT-----------------STRVF----------YISVCVCCIVI 237

  Fly   250 GILALVLVSTLILIAYCAK------GPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVC---- 304
            .::|::|.   :|..:..|      ..|....|.|:....|.:.|.|.  :.|.:|:..|.
Zfish   238 FLVAIILA---VLHLHSMKRVEMDDSVSDSGSSQGLSQPSTQTTQYLR--ADTPNNATPVTNAQT 297

  Fly   305 -------------PSTITPTYATLTRPFREYEHEP------EEFNRRLQELTVQKCRVRLSCLVQ 350
                         |....|::.|.:.|....|...      .|...:::::.:.:.||.|..::.
Zfish   298 GSAPMLQLAGASFPHPGAPSHETKSYPSLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLRDVLH 362

  Fly   351 EGNFGRIYRGTYND------CQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIE 409
            ||.||||:.|...|      .::|.||.|..|||::||.::|.||..|....|.|:|.:..:.||
Zfish   363 EGTFGRIFHGVLLDEKDPSKEKQVFVKAVKDHASEVQVTMMLTESCKLRGLHHRNLLPISHVCIE 427

  Fly   410 DYATPFVL--YAATGSVRNLKSFLQDPSYA-----RSVTTIQTVLMGSQLAMAMEHLHNHGVIHK 467
            |...|.||  |...|   |||.||:....|     ::::....|.|..|::..|.:|....||||
Zfish   428 DGEKPMVLLPYMNWG---NLKLFLRQCKLAEANNPQAISQQDLVHMAIQISCGMSYLARREVIHK 489

  Fly   468 DIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFG 532
            |:||||||||:.::||:||:||:|||||.||:.|||.|.||::|::||:|..:.::..||||:||
Zfish   490 DLAARNCVIDNSMQVKITDNALARDLFPMDYHCLGDNENRPVRWMALESLLNNDFSSASDVWAFG 554

  Fly   533 VLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQI 597
            |.:||:.|||:.||.:|||:||..|||||||:|||.|||||||.:||.|||..|.|||.|.||..
Zfish   555 VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ 619

  Fly   598 CLSEFHTQITRYV 610
            ||:|||..:..||
Zfish   620 CLTEFHAALGAYV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	49/135 (36%)
		PTK_Ryk	336..606	CDD:270639	135/282 (48%)
ryk	XP_005165988.1	WIF	63..184	CDD:460414	43/125 (34%)
		PTK_Ryk	348..628	CDD:270639	135/282 (48%)