Protein Alignment drl and AXL

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_068713.2
• Gene: AXL / 558
• HGNCID: 905
• Length: 894
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 160/656 - (24%)
• Similarity: 261/656 - (39%)
• Gaps: 171/656 - (26%)

  Fly    27 NLHEVLR------------LIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTWQSLVDHPL 79
            |||.|.|            |.|:....:...:..::|..:......|....:...:..|:..|.|
Human   230 NLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQL 294

  Fly    80 ---------PYSINIA-------TSDTEVLP---------RPILNIS--RIGD----------VP 107
                     ||.|.:|       :|.|..||         .|..|||  |.|.          .|
Human   295 RLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAP 359

  Fly   108 VEPQTWGIALKCSGTRNAEVTVTINV--EVIL----DRATNNNTNLIFKRKKICLREEQDSAHEE 166
            ::....|..|...|....||.:.|.:  ||.|    |.:.:|.|        :|:     :|:..
Human   360 LQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT--------VCV-----AAYTA 411

  Fly   167 YDDDDLDL---LQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDF 228
            ..|....|   |:..|.|....:|
Human   412 AGDGPWSLPVPLEAWRPGQAQPVH----------------------------------------- 435

  Fly   229 DPMLRENLVPPAS-GLVTLIVGGILALVLVSTLILIAYCAKGPSKRH-----PS--NGVHLIK-- 283
             .:::|...|..| ....:::|.::|...|..|.|.....:....|:     |:  .|..:::
Human   436 -QLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYR 499

  Fly   284 -TSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSC 347
             ..|:.|..|.::.  ||:.:                      .||...:|:::.|.:.:|.|..
Human   500 VRKSYSRRTTEATL--NSLGI----------------------SEELKEKLRDVMVDRHKVALGK 540

  Fly   348 LVQEGNFGRIYRGTYNDCQEVL---VKTV-AQHASQLQVNLLLQESMMLYEASHPNVLSVLGISI 408
            .:.||.||.:..|..|....:|   |||: ....::.::...|.|::.:.|..||||:.::|:..
Human   541 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCF 605

  Fly   409 -----EDYATPFVL--YAATGSVRNLKSFL------QDPSYARSVTTIQTVLMGSQLAMAMEHLH 460
                 |.:..|.|:  :...|   :|.|||      ..|.|   :.|...|...:.:|..||:|.
Human   606 QGSERESFPAPVVILPFMKHG---DLHSFLLYSRLGDQPVY---LPTQMLVKFMADIASGMEYLS 664

  Fly   461 NHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEG 525
            ....||:|:|||||::::.:.|.:.|..||:.::.|||...|.....|:||:::|:|....|...
Human   665 TKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK 729

  Fly   526 SDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERP 590
            ||||||||.|||:.|.|:.||..::..|:..||:.|.||.||.:|.|.|:.:|:.||...|.:||
Human   730 SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRP 794

  Fly   591 SFSQLQ 596
            ||::|:
Human   795 SFTELR 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	40/184 (22%)
		PTK_Ryk	336..606	CDD:270639	94/278 (34%)
AXL	NP_068713.2	interaction with Gas6	26..92
		IgI_1_Axl_like	35..135	CDD:409558
		Ig strand A	35..40	CDD:409558
		Ig strand A'	43..46	CDD:409558
		Ig strand B	50..60	CDD:409558
		Ig strand C	66..71	CDD:409558
		Ig strand C'	74..76	CDD:409558
		Ig strand D	81..88	CDD:409558
		Ig strand E	95..106	CDD:409558
		Ig strand F	113..121	CDD:409558
		Ig strand G	124..135	CDD:409558
		IgI_2_Axl_Tyro3_like	140..222	CDD:409407
		Ig strand A	140..143	CDD:409407
		Ig strand A'	146..150	CDD:409407
		Ig strand B	154..163	CDD:409407
		Ig strand C	168..175	CDD:409407
		Ig strand C'	177..180	CDD:409407
		Ig strand E	186..197	CDD:409407
		Ig strand F	200..209	CDD:409407
		Ig strand G	213..222	CDD:409407
		FN3	225..328	CDD:238020	20/97 (21%)
		fn3	335..418	CDD:394996	22/95 (23%)
		PTKc_Axl	535..811	CDD:270660	93/272 (34%)