Protein Alignment drl and ryk

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_012825927.1
• Gene: ryk / 550026
• XenbaseID: XB-GENE-485290
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 615
• Identity: 221/615 - (35%)
• Similarity: 326/615 - (53%)
• Gaps: 93/615 - (15%)

  Fly    22 LNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTW--QSLVDHPLPYSIN 84
            ||::|:..||.||||:.|||||:|...||.|||:|.:.||:..:.:.|||  :|.|::.|.:.::
 Frog    54 LNLYLSEEEVRRLIGLDAELYYIRNDIINHYALSFNLLVPSETNSLHFTWHAKSKVEYKLGFQVD 118

  Fly    85 IATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIF 149
                :...:..|:.|||..|:||.....:.:.|.|||..::||...:.:.:.:..| .|.|.|.|
 Frog   119 ----NPMAMTMPLTNISMQGEVPSSLTVFRVDLYCSGKMDSEVLFLMQLNITISSA-KNITVLNF 178

  Fly   150 KRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTES 214
            ||:|:|.|        :.:|..:.:||             |:|:..:
 Frog   179 KRRKMCYR--------KLEDIKVPVLQ-------------DKNNTRI------------------ 204

  Fly   215 PVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKR------ 273
                        .|||:   |:.|..|..|..|..|:...|:....|::|.......||
 Frog   205 ------------HFDPV---NVAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRVELDDS 254

  Fly   274 ----HPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEP-EEFNRRL 333
                ..|.|:....|.:.|.|.  :.|.:|:   .|.|.:..|.||.....:.:... :|...::
 Frog   255 MSDSSSSQGLSQPSTQTTQYLR--ADTPNNA---TPVTSSSGYPTLRIEKNDLKSVTLQEAKAKV 314

  Fly   334 QELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQE------VLVKTVAQHASQLQVNLLLQESMML 392
            :::.:.:.||.|..::|||.||||:.|...|.::      |.||||...||::|:.::|.||..|
 Frog   315 KDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKAVFVKTVKDQASEVQITMMLTESCKL 379

  Fly   393 YEASHPNVLSVLGISIEDYATPFVL--YAATGSVRNLKSFLQ-----DPSYARSVTTIQTVLMGS 450
            ....|.|:|.:..:..||...|.||  |...|   |||.||:     :.:..::::....|.|..
 Frog   380 RGLHHRNLLPIGHVCTEDGEKPMVLLPYMNWG---NLKLFLRQCKLVEANNPQAISQQDLVHMAI 441

  Fly   451 QLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLE 515
            |:|..|.:|....|||||:||||||||:.|:||:||:||||||||.||:.|||.|.||::|::||
 Frog   442 QIACGMSYLARREVIHKDLAARNCVIDESLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALE 506

  Fly   516 ALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAY 580
            :|....::...|||:|||.:||:.|||:.||.:|||:||..|||||||:|||.|||||||.:||.
 Frog   507 SLVNKEFSSAGDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMAC 571

  Fly   581 CWASMPAERPSFSQLQICLSEFHTQITRYV 610
            |||..|.|||.|.||..||:|||:.:..||
 Frog   572 CWALDPEERPKFQQLVQCLTEFHSALGAYV 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	51/136 (38%)
		PTK_Ryk	336..606	CDD:270639	135/282 (48%)
ryk	XP_012825927.1	WIF	57..180	CDD:460414	45/127 (35%)
		PTK_Ryk	317..597	CDD:270639	135/282 (48%)