DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and ROR2

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:561 Identity:123/561 - (21%)
Similarity:210/561 - (37%) Gaps:165/561 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 CLR-----EEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQA-------PEKQ 207
            |:|     |.....|:.|:...:|...||                ....:|||.       |...
Human   300 CMRIGIPAERLGRYHQCYNGSGMDYRGTA----------------STTKSGHQCQPWALQHPHSH 348

  Fly   208 RPVVTESP-VGRG-----NSGG------------------------SKRDFDPMLRENLVPPASG 242
            ....|:.| :|.|     |.||                        |.||...|          |
Human   349 HLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKM----------G 403

  Fly   243 LVTLIVGGI-LALVLVSTLILIAYC-------AKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHN 299
            ::.::|..| :.||:.....|:..|       |..|.:|.     .:...|....:|.|:     
Human   404 ILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQ-----LMASPSQDMEMPLIN----- 458

  Fly   300 SIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY-- 362
                                   :|:    ..:|:|:::.  .||....:.|..||::|:|..  
Human   459 -----------------------QHK----QAKLKEISLS--AVRFMEELGEDRFGKVYKGHLFG 494

  Fly   363 ----NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL-YAATG 422
                ...|.|.:||:...|..........|:|:.....||||:.:||:..:|.....:. |.:.|
Human   495 PAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 559

  Fly   423 SV-------------------RNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKD 468
            .:                   |.:||.|:.|.:...|         :|:|..||:|.:|.|:|||
Human   560 DLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV---------AQIAAGMEYLSSHHVVHKD 615

  Fly   469 IAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGV 533
            :|.||.::.|:|.||::|..|.|:::..||..|......||:|::.||:....::..||:||:||
Human   616 LATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGV 680

  Fly   534 LMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQIC 598
            ::||:.:.|..||......::...:::...|..|.:||..::.:|..||...|:.||.|      
Human   681 VLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRF------ 739

  Fly   599 LSEFHTQITRYVXPAVLKHAKTCKYNKRRRRKIFQQTTSST 639
             .:.|:::..:        .....||...:......||.::
Human   740 -KDIHSRLRAW--------GNLSNYNSSAQTSGASNTTQTS 771

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 1/1 (100%)
PTK_Ryk 336..606 CDD:270639 80/295 (27%)
ROR2NP_004551.2 I-set 64..152 CDD:400151
Ig strand B 79..83 CDD:409353
Ig strand C 92..96 CDD:409353
Ig strand E 118..122 CDD:409353
Ig strand F 132..137 CDD:409353
Ig strand G 145..148 CDD:409353
CRD_TK_ROR2 170..309 CDD:143577 2/8 (25%)
KR 314..395 CDD:214527 16/96 (17%)
PTKc_Ror2 466..749 CDD:270673 81/300 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796 2/15 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931
Blue background indicates that the domain is not in the aligned region.

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