DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and NTRK3

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:XP_016877743.1 Gene:NTRK3 / 4916 HGNCID:8033 Length:850 Species:Homo sapiens


Alignment Length:723 Identity:153/723 - (21%)
Similarity:272/723 - (37%) Gaps:217/723 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LTLIASGQAHLNIF-LNLHEV-LRLIGVSAELYYVREGAINDYAL----NFAVPVPANISDVTFT 70
            |..|.:..:.|.:| :|:.:. |..|.||.....||||   |.|:    ....|:| ::..:...
Human   187 LYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREG---DNAVITCNGSGSPLP-DVDWIVTG 247

  Fly    71 WQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKC-----SGTRNAEVTVT 130
            .||:..|    ..|:..::...:...::|::        .:..|..|.|     .|..||.|.:|
Human   248 LQSINTH----QTNLNWTNVHAINLTLVNVT--------SEDNGFTLTCIAENVVGMSNASVALT 300

  Fly   131 I--------------NVEVILDRATNNN--TNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTAR 179
            :              .:|..::.....|  ..|.:......|||.: ..|.||..:         
Human   301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESK-IIHVEYYQE--------- 355

  Fly   180 KGHGGDI-----------HYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGN---SGGSKRDFDP 230
                |:|           ||         .||:..      ::.::|:|..|   :|...::..|
Human   356 ----GEISEGCLLFNKPTHY---------NNGNYT------LIAKNPLGTANQTINGHFLKEPFP 401

  Fly   231 MLRENLV--------PPASGL---------VTLIVG--GILALVLVSTLILI-------AYCAKG 269
            ...:|.:        ||.:..         |::.||  ....::||...::|       .:..||
Human   402 ESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKG 466

  Fly   270 P-----------SKRHPSNGVHLIKTSS------------FQRLPTISSTAHNSIYVCPSTITPT 311
            |           |..|..|  |.|.|.|            ..|:|.|.:              |.
Human   467 PVAVISGEEDSASPLHHIN--HGITTPSSLDAGPDTVVIGMTRIPVIEN--------------PQ 515

  Fly   312 YATLTRPFREYE--HEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRG-TYN-----DCQEV 368
            |      ||:..  |:|:.:.:.     :::..:.|...:.||.||:::.. .||     |...|
Human   516 Y------FRQGHNCHKPDTYVQH-----IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLV 569

  Fly   369 LVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL---YAATGSVRNLKSF 430
            .||.:.......:.: ..:|:.:|....|.:::...|:..:  ..|.::   |...|   :|..|
Human   570 AVKALKDPTLAARKD-FQREAELLTNLQHEHIVKFYGVCGD--GDPLIMVFEYMKHG---DLNKF 628

  Fly   431 LQ------------DPSYARSVTTIQTVL-MGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRV 482
            |:            .|..|:....:..:| :.||:|..|.:|.:...:|:|:|.|||::...|.|
Human   629 LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV 693

  Fly   483 KLTDSALSRDLFPGDY-------------------------NSLGDGEYRPIKWLSLEALQKSHY 522
            |:.|..:|||::..||                         :::|.....||:|:..|::....:
Human   694 KIGDFGMSRDVYSTDYYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKF 758

  Fly   523 NEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPA 587
            ...||||||||::||:.|.||.|:.::...|:...:..|..|.:|..||.|::.:|..||...|.
Human   759 TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQ 823

  Fly   588 ERPSFSQL 595
            :|.:..::
Human   824 QRLNIKEI 831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 31/162 (19%)
PTK_Ryk 336..606 CDD:270639 75/307 (24%)
NTRK3XP_016877743.1 LRR_8 103..160 CDD:404697
leucine-rich repeat 105..128 CDD:275378
leucine-rich repeat 129..151 CDD:275378
leucine-rich repeat 152..164 CDD:275378
LRRCT_2 163..208 CDD:465313 5/20 (25%)
ig 214..299 CDD:395002 22/100 (22%)
Ig strand B 227..231 CDD:409568 1/3 (33%)
Ig strand C 240..244 CDD:409568 0/3 (0%)
Ig strand E 266..270 CDD:409568 0/3 (0%)
Ig strand F 281..286 CDD:409568 2/4 (50%)
Ig strand G 294..297 CDD:409568 2/2 (100%)
IgI_TrKABC_d5 304..396 CDD:409360 19/120 (16%)
Ig strand A 305..311 CDD:409360 0/5 (0%)
Ig strand A' 313..316 CDD:409360 0/2 (0%)
Ig strand B 319..327 CDD:409360 0/7 (0%)
Ig strand C 330..337 CDD:409360 1/6 (17%)
Ig strand C' 340..343 CDD:409360 0/2 (0%)
Ig strand D 348..354 CDD:409360 3/5 (60%)
Ig strand E 358..366 CDD:409360 1/7 (14%)
Ig strand F 374..382 CDD:409360 1/13 (8%)
Ig strand G 385..393 CDD:409360 2/7 (29%)
PTKc_TrkC 532..843 CDD:270676 75/311 (24%)
Blue background indicates that the domain is not in the aligned region.

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