Protein Alignment drl and zap70

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001006825.1
• Gene: zap70 / 448557
• XenbaseID: XB-GENE-956409
• Length: 609
• Species: Xenopus tropicalis
• Alignment Length: 523
• Identity: 123/523 - (23%)
• Similarity: 220/523 - (42%)
• Gaps: 90/523 - (17%)

  Fly   111 QTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLL 175
            |||  .|:......|.::....||.::  ||..:..:.:....|...|.:...:.....|...|:
 Frog   129 QTW--KLEGDALEQAIISQAPQVEKLI--ATTAHERMAWYHGTISRDEAERKLYSGAQPDGKFLM 189

  Fly   176 QTARKG--------HGGDI-HYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPM 231
            :..::.        :|..: ||....|:   :..:..||                 |:|.|....
 Frog   190 RERKENGTYALSVMYGKTVYHYKIDQDK---SGKYSIPE-----------------GTKFDTLWQ 234

  Fly   232 LRENLVPPASGLVTLIVGGILALVLV----STLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPT 292
            |.|.|        .|...||:|::..    |....||..|..||                  ||.
 Frog   235 LVEYL--------KLKSDGIMAVLKESCPNSCTFSIAPAAAPPS------------------LPK 273

  Fly   293 ISSTAHNSIYVCPSTITPTYATLTRPFREYE---HEPEEFNRRLQELTVQKCRVRLSCLVQE--- 351
            |...|.||....|.........|......||   .:|||...|  :|.|:    |...|:.|
 Frog   274 IRQAASNSDGYTPEPFIGKSRILPMDTSVYESPYSDPEELKER--KLFVK----RELLLIDEVEL 332

  Fly   352 --GNFGRIYRGTYNDCQ---EVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDY 411
              ||||.:.:|.|...:   :|.:|.:.....:...:.:::|:.::::..:|.::.::|: .|..
 Frog   333 GSGNFGCVKKGVYKLKKRQIDVAIKVLKVQDEKNVRDEMMKEAEIMHQLDNPYIVRMIGV-CEAE 396

  Fly   412 ATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVL-MGSQLAMAMEHLHNHGVIHKDIAARNCV 475
            ....|:..|:|.  .|..||   ...:.|..:..:: :..|:::.|::|.....:|:|:||||.:
 Frog   397 NLMLVMEMASGG--PLNKFL---GAKKDVIPMSNIVELMHQVSIGMKYLEGKNFVHRDLAARNVL 456

  Fly   476 IDDQLRVKLTDSALSRDLFPGD--YNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEM 538
            :.:|...|::|..||:.|...|  |.:...|:: |:||.:.|.:....::..|||||:|:.|||.
 Frog   457 MVNQHYAKISDFGLSKALAADDSYYKAKSFGKW-PLKWYAPECINYRKFSSRSDVWSYGITMWEA 520

  Fly   539 CTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFH 603
            .|.|:.||.::...|:..:::...|||.|..||.|::.:|..||.....:||:|..::..:..::
 Frog   521 FTYGQKPYKKLKGTEVMSFIERNERLACPAGCPPEMYQVMLDCWIFKMEDRPNFDNVEYRMRMYY 585

  Fly   604 TQI 606
            ..|
 Frog   586 YSI 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	10/45 (22%)
		PTK_Ryk	336..606	CDD:270639	73/280 (26%)
zap70	NP_001006825.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191
		SH2_C-SH2_Zap70	152..256	CDD:198265	22/133 (17%)
		Protein Kinases, catalytic domain	321..589	CDD:473864	72/279 (26%)