Protein Alignment drl and InR

DIOPT Version :9

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001138093.1
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 144/600 - (24%)
• Similarity: 243/600 - (40%)
• Gaps: 158/600 - (26%)

  Fly   134 EVILDRATNNNTNLIFKRKK---------ICLREE------QDSAHEEYDDDDLD-LLQTARKGH 182
            ||.......|.|:.:|::.:         :..|||      :|::.::....|.| :.||.::..
  Fly  1138 EVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKK 1202

  Fly   183 GGDIHYVDRND-EHVVANGHQAPEKQRPVVTESPVG----------------------------- 217
            ..||....:.| ||  ||..::|.:.|......|.|
  Fly  1203 FADIVMDLKVDLEH--ANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFN 1265

  Fly   218 ------------------RGNSGGSKRDFDPMLRENLVPPAS--GLVTLIVGGILALVLVSTLIL 262
                              |.||.....||..:....:.||.|  .:...::|..||.::||....
  Fly  1266 QTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGY 1330

  Fly   263 IAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPE 327
            :.|..|   ::.|||.:|:                       .:.:.|.||::       ::.|:
  Fly  1331 VCYLHK---RKVPSNDLHM-----------------------NTEVNPFYASM-------QYIPD 1362

  Fly   328 EFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDC------QEVLVKTVAQHASQLQVNLLL 386
            :: ..|:|..:|     |:.|.| |:||.:|.|.....      :|..:|||.::|:..:....|
  Fly  1363 DW-EVLRENIIQ-----LAPLGQ-GSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFL 1420

  Fly   387 QESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFL-------------------- 431
            .|:.::.|....:|:.:||:.  ....|.::........:|||:|
  Fly  1421 SEASVMKEFDTYHVVRLLGVC--SRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIG 1483

  Fly   432 -----QDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR 491
                 |.|:|.|      ...|..::|..|.:|.....:|:|:|||||::.|.|.||:.|..::|
  Fly  1484 VTGNVQPPTYGR------IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR 1542

  Fly   492 DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEH 556
            |::..||...|.....|::|:..|:|:...|:..|||:||||::|||.||...||..:...::..
  Fly  1543 DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLR 1607

  Fly   557 YLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQI-------CLSEFHTQITRYVXPAV 614
            |:.||..:.:|.||||.|..:|..||....:.||||  |.|       |.:....:::.|...|.
  Fly  1608 YVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSF--LDIIAYLEPQCPNSQFKEVSFYHSEAG 1670

  Fly   615 LKHAKTCKYNKRRRR 629
            |:|.:  |..|.|.:
  Fly  1671 LQHRE--KERKERNQ 1683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	5/31 (16%)
		PTK_Ryk	336..606	CDD:270639	88/307 (29%)
		Pkinase_Tyr	343..599	CDD:285015	86/293 (29%)
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	8/77 (10%)
		PTKc_InsR_like	1364..1652	CDD:173625	89/304 (29%)
		Pkinase_Tyr	1371..1650	CDD:285015	87/294 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940