Protein Alignment drl and MET

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_011514525.1
• Gene: MET / 4233
• HGNCID: 7029
• Length: 1409
• Species: Homo sapiens
• Alignment Length: 723
• Identity: 164/723 - (22%)
• Similarity: 297/723 - (41%)
• Gaps: 197/723 - (27%)

  Fly     9 GLLLTLIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDY------ALNFAVPVPANISDV 67
            |.||||..:   :||...:.|  :.:.|.:..|..|....:..|      :..|||.:..::::.
Human   691 GTLLTLTGN---YLNSGNSRH--ISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANR 750

  Fly    68 TFTWQSLVDHPLPYSINIATS---------------DTEVLPRPILNISRIGDVPVEPQTWGIAL 117
            ..:..|..:.|:.|.|:...|               ::..:||.::|:...|.        ...:
Human   751 ETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGR--------NFTV 807

  Fly   118 KCSGTRNAEVTV-------TINVEV--------ILDRATNNNTNLIFKRKKICLREEQ----DSA 163
            .|....|:|:..       .:|:::        :||...:...:||:....:....|:    ...
Human   808 ACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMG 872

  Fly   164 HE---EYDDDDLD-------LLQTARKG------HGGDIHYVDRNDEHVVANGHQAPEKQRPVVT 212
            :|   |...:|:|       :|:...|.      |...:.....||  ::....:...:.:..::
Human   873 NENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPND--LLKLNSELNIEWKQAIS 935

  Fly   213 ESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLIL--------------- 262
            .:.:|:                .:|.|......||.|    :|.:||.:|
Human   936 STVLGK----------------VIVQPDQNFTGLIAG----VVSISTALLLLLGFFLWLKKRKQI 980

  Fly   263 ---------------------------------------IAYCAKGPSKRHPS---NG------- 278
                                                   :.|.|..|..:.|:   ||
Human   981 KDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQY 1045

  Fly   279 ----VHLIKTSSFQRL--PTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELT 337
                :..|.||....:  |.:.:|.|..:    |.:.|                 |..:.:|.:.
Human  1046 PLTDMSPILTSGDSDISSPLLQNTVHIDL----SALNP-----------------ELVQAVQHVV 1089

  Fly   338 V--QKCRVRLSCLVQEGNFGRIYRGTY--NDCQEV--LVKTVAQHASQLQVNLLLQESMMLYEAS 396
            :  ....|..:.::..|:||.:|.||.  ||.:::  .||::.:.....:|:..|.|.:::.:.|
Human  1090 IGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFS 1154

  Fly   397 HPNVLSVLGISIEDYATPFVL--YAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHL 459
            ||||||:|||.:....:|.|:  |...|.:||   |:::.::..:|..:  :..|.|:|..|::|
Human  1155 HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRN---FIRNETHNPTVKDL--IGFGLQVAKGMKYL 1214

  Fly   460 HNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGD--GEYRPIKWLSLEALQKSHY 522
            .:...:|:|:|||||::|::..||:.|..|:||::..:|.|:.:  |...|:||::||:||...:
Human  1215 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF 1279

  Fly   523 NEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPA 587
            ...|||||||||:||:.|.|..||.:::.:::..||..|.||.||..|||.|:.:|..||.....
Human  1280 TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAE 1344

  Fly   588 ERPSFSQL 595
            .|||||:|
Human  1345 MRPSFSEL 1352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	27/171 (16%)
		PTK_Ryk	336..606	CDD:270639	96/270 (36%)
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539
		PSI	538..580	CDD:214655
		IPT_plexin_repeat1	582..675	CDD:238585
		IPT_plexin_repeat2	676..759	CDD:238584	16/72 (22%)
		IPT_plexin_repeat3	761..856	CDD:238586	16/102 (16%)
		IPT	857..953	CDD:214657	13/113 (12%)
		PTKc_Met_Ron	1101..1362	CDD:270649	95/257 (37%)