Protein Alignment drl and Egfr

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 130/613 - (21%)
• Similarity: 225/613 - (36%)
• Gaps: 142/613 - (23%)

  Fly   119 CSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQ--DSAHEEY----DDDDLDLL-- 175
            |.|....:.|:.|......:.|..||...:   |:..|::::  |....||    :...|..|
  Fly   672 CDGCTGPKDTIGIGACTTCNLAIINNDATV---KRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAG 733

  Fly   176 -QTARKGH----------------GGDIHYVDRND-EHVVANGHQAPEKQRPVVTESPVGRGNSG 222
             ...||.|                ....||..|.. |......|...|:||......|...|.:|
  Fly   734 RAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTG 798

  Fly   223 GSKRD---------FD-----PMLRENLV---------------------------PPASGLVT- 245
            ....|         ||     |.:...:.                           ||.|..:|
  Fly   799 PGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITA 863

  Fly   246 -------LIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYV 303
                   .|:.|.:.:..:..|.::.|..:...|               .:..|:..|.  ::..
  Fly   864 NLDVNMIFIITGAVLVPTICILCVVTYICRQKQK---------------AKKETVKMTM--ALSG 911

  Fly   304 CPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQK-CRVRLSCLVQEGNFGRIYRGTYND--- 364
            |..         :.|.|     |......|.:|.:.| ..:|...::..|.|||:|:|.:..
  Fly   912 CED---------SEPLR-----PSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGE 962

  Fly   365 -------CQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATG 422
                   .:|:|..|.|:.:.:     .|:|:.::....|.|:|.:|.:.:.............|
  Fly   963 NVKIPVAIKELLKSTGAESSEE-----FLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLG 1022

  Fly   423 SVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDS 487
            .:.:.....:|...::::....|     |:|..|.:|....::|:|:||||.::.....||:||.
  Fly  1023 CLLDYVRNNRDKIGSKALLNWST-----QIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDF 1082

  Fly   488 ALSRDLFPGDYNSLGDGEYR------PIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546
            .|:: |...|.|     ||:      |||||:||.::...:...||||:|||.:||:.|.|:.|:
  Fly  1083 GLAK-LLSSDSN-----EYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPH 1141

  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYVX 611
            ..|...::...::.|.:|.||..|..:::..:..||....|.||:|.||....:||.....||:
  Fly  1142 ENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLA 1206

  Fly   612 PAVLKHAKTCKYNKRRRRKIFQQTTSST 639
            ....|..:...|..:..:.:.::...:|
  Fly  1207 IPGDKFTRLPAYTSQDEKDLIRKLAPTT 1234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	8/37 (22%)
		PTK_Ryk	336..606	CDD:270639	77/286 (27%)
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	3/11 (27%)
		FU	662..716	CDD:214589	10/46 (22%)
		GF_recep_IV	740..>834	CDD:464344	16/93 (17%)
		PTKc_EGFR_like	930..1208	CDD:270648	79/293 (27%)