DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and INSRR

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_055030.1 Gene:INSRR / 3645 HGNCID:6093 Length:1297 Species:Homo sapiens


Alignment Length:397 Identity:101/397 - (25%)
Similarity:183/397 - (46%) Gaps:59/397 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 LVPPASGLVTLIVGGILALVLVSTLI-------LIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTI 293
            |:||         |...|.|..::|.       .:|:...|| :...:.|:|::.|::...|..:
Human   880 LLPP---------GNYSARVRATSLAGNGSWTDSVAFYILGP-EEEDAGGLHVLLTATPVGLTLL 934

  Fly   294 SSTA----------HNSIYVCPSTITPTYATLTRPFREYEHE-PEEFNRRLQELTVQKCRVRLSC 347
            ...|          :.::|   :::.|.|.:.:..:...|.| |.|....::||           
Human   935 IVLAALGFFYGKKRNRTLY---ASVNPEYFSASDMYVPDEWEVPREQISIIREL----------- 985

  Fly   348 LVQEGNFGRIYRG------TYNDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI 406
              .:|:||.:|.|      ...:...|.:|||.:.||..:....|:|:.::......:|:.:||:
Human   986 --GQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGV 1048

  Fly   407 SIEDYATPFVLYAATGSVRNLKSFLQD--PSYARSVTTIQTVL-----MGSQLAMAMEHLHNHGV 464
            ..:...|..::...|..  :|||.|:.  |....:....|..|     |..::|..|.:|..:..
Human  1049 VSQGQPTLVIMELMTRG--DLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKF 1111

  Fly   465 IHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVW 529
            :|:|:|||||::.....||:.|..::||::..||...|.....|::|::.|:|:...:...||||
Human  1112 VHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVW 1176

  Fly   530 SFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQ 594
            ||||::||:.||.:.||..:...::..::.||..|.:...||.:|..:|:.||...|..||||:.
Human  1177 SFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTH 1241

  Fly   595 LQICLSE 601
            :...:.|
Human  1242 ILDSIQE 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745
PTK_Ryk 336..606 CDD:270639 78/279 (28%)
INSRRNP_055030.1 Recep_L_domain 47..158 CDD:460032
Furin-like 173..326 CDD:395614
Recep_L_domain 346..461 CDD:460032
FN3 <489..>640 CDD:442628
FN3 605..>649 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..687
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..758
FN3 819..908 CDD:238020 8/36 (22%)
PTKc_InsR_like 972..1248 CDD:173625 81/290 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1297
Blue background indicates that the domain is not in the aligned region.

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