Protein Alignment drl and Drl-2

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_610835.2
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 691
• Identity: 238/691 - (34%)
• Similarity: 338/691 - (48%)
• Gaps: 136/691 - (19%)

  Fly     3 PNLLTIGLLLTLIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDV 67
            |.||   |.||:..|...:||||::.|||::|:|:.|:|:||.|||||.||::|.|||||::.::
  Fly    11 PILL---LCLTISTSVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHEL 72

  Fly    68 TFTWQSLVDHPLPYSINIA-TSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTI 131
            .|:||||:.:||||:|:|. .:|.|.|..|.|:|...|.||.|.:::.:.|.|:|  ||.:.:.:
  Fly    73 EFSWQSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTG--NASLQMPV 135

  Fly   132 NVEVILDRATN--NNTNLIFKRKKICLR-----EEQDSAHEEYDDDDLDLLQTARKGHG------ 183
            ||.::: ||..  |:|.|.|||.|||.:     ..|..|..........||..|....|
  Fly   136 NVNMVV-RAPPRFNDTRLHFKRNKICAKGISPEPNQSPAPAHAPSQGPALLSAAACALGLVLAVG 199

  Fly   184 --GDIHYVD-----RNDE-HVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPA 240
              ..:.||.     |.|. |...........|...:...|:||                  .|.|
  Fly   200 LVASMMYVRARKQLRQDSLHTSFTTAAYGSHQNVFIRLDPLGR------------------PPSA 246

  Fly   241 SGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRL-----PTISSTA--- 297
            :|                     :|.......::|::...  ..|.|.|.     ||..:||
  Fly   247 TG---------------------SYATIASLNKYPADSKK--SCSIFDRFRSSPTPTPYATALLP 288

  Fly   298 ------HNSIY-----VCPSTIT----------------------------------------PT 311
                  ..:||     :|||.|:                                        ||
  Fly   289 MNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPT 353

  Fly   312 YATLTRPFREYEHEPEEFNRRLQELT-VQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQ 375
            .:|:|     .....|:.|:||:.:| ||...:....||:||.|||||.|...:..|.|||||..
  Fly   354 GSTIT-----MASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAGKLGESCEALVKTVID 413

  Fly   376 HASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQ-DPSYARS 439
            .||..||..|||::.:|...||.::|:.|..:.|....|.:.|... |..|||.:|| ....:.:
  Fly   414 GASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHP-SKGNLKMYLQKSRESSTA 477

  Fly   440 VTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDG 504
            ::|.|.|..|..:...:.:||:.|::|||||.|||.:|::..||:.||||||||||.||:.|||.
  Fly   478 LSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDN 542

  Fly   505 EYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFN 569
            |.||:||||||:|||..|....|||:.||..||:.||.::|:.|:|.:|:.:||..|:||.||.|
  Fly   543 ENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVN 607

  Fly   570 CPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            ||||.||:|..||.....:||:.|||...|.:||..:..|:
  Fly   608 CPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	65/138 (47%)
		PTK_Ryk	336..606	CDD:270639	124/271 (46%)
Drl-2	NP_610835.2	WIF	30..156	CDD:460414	57/128 (45%)
		PTK_Ryk	373..644	CDD:270639	124/271 (46%)