Protein Alignment drl and dnt

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 355/615 - (57%)
• Similarity: 440/615 - (71%)
• Gaps: 74/615 - (12%)

  Fly    11 LLTLIA----SGQ---AHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVT 68
            ||.|.|    ||.   ||||:|||..||:||:|||||:||||||.||:|||||.||||||:.|::
  Fly    29 LLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVPANVKDIS 93

  Fly    69 FTWQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINV 133
            ||||||....||||||:.:||.||||||.:|:|..|::|...|||.|||||||.:.|||.||:::
  Fly    94 FTWQSLAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSL 158

  Fly   134 EVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVA 198
            ||:|:|:.||.|:|:|:||||||.  .|||.:..:|.|
  Fly   159 EVVLNRSLNNVTHLVFRRKKICLM--NDSAEDLSEDVD--------------------------- 194

  Fly   199 NGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILI 263
                                          ||.|.|.::.|.:||:||:||..:|:..|..|::|
  Fly   195 ------------------------------DPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMI 229

  Fly   264 AYCAKGPS--KRHPSNGVHLIKTSSFQRL---PTISSTAHNSIYVCPSTITPTY-ATLTR--PFR 320
            |||.||.:  ::|..:|...::|||||||   |...|:..::.|:.||.|.|.: ::|.|  |..
  Fly   230 AYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVS 294

  Fly   321 EYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQHASQLQVNLL 385
            ..:..|||.:||:.||||::||||||.|:|||.|||:|||||||.|:||||||||||||:||.||
  Fly   295 VEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLL 359

  Fly   386 LQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGS 450
            |||.|:||.||||.:|||||:||||:.||||||.|..:.||||.||.||:.||:|||||.|:|.|
  Fly   360 LQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVTTIQIVMMAS 424

  Fly   451 QLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLE 515
            ||:||::|||:|||:|||||.|||||||||||||:||:|||||||.|||.|||.|.||:||:|||
  Fly   425 QLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLE 489

  Fly   516 ALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAY 580
            |||...::|.||.|:|||||||:||..|.||||:||:||||||||||||||||||||||||||||
  Fly   490 ALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAY 554

  Fly   581 CWASMPAERPSFSQLQICLSEFHTQITRYV 610
            |||.:|||||:|:|||.|||||::||||||
  Fly   555 CWALLPAERPTFAQLQSCLSEFYSQITRYV 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	88/135 (65%)
		PTK_Ryk	336..606	CDD:270639	203/269 (75%)
dnt	NP_477341.2	WIF	46..182	CDD:128745	88/135 (65%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	203/269 (75%)