DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and sev

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	156/690 - (22%)
Similarity:	274/690 - (39%)	Gaps:	186/690 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTWQSLVDHPL- 79
            :|.:.|:..|..|.| |:|:            .:..|:|             :.||....| ||
  Fly  1890 SSERLHVRSFAELPE-LQLL------------ELGPYSL-------------SLTWAGTPD-PLG 1927

  Fly    80 -----------PYSINIATSDTEVLPRPILNISR---------------------------IGDV 106
                       ....|:|.:.|:::..|:...:|                           :||.
  Fly  1928 SLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDA 1992

  Fly   107 PVEP--------------QTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLR 157
            |.:|              .||..|     ..|.......|:|.:..|:.       .:|::...|
  Fly  1993 PSQPGKPQLEHIAEEVFRVTWTAA-----RGNGAPIALYNLEALQARSD-------IRRRRRRRR 2045

  Fly   158 EEQDSAHEE---------YDDDDLDLLQT------ARKGHGGDI---HYVDRNDEHVVANGHQAP 204
            .....:.|:         .:|..||...|      .:..|...:   ....|:.||  ..|..:.
  Fly  2046 RNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEH--GWGPYSE 2108

  Fly   205 EKQR---PVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYC 266
            |.:|   |.|  ||..||:           |...::.||:    ::...:||||||..:......
  Fly  2109 ESERVAEPFV--SPEKRGS-----------LVLAIIAPAA----IVSSCVLALVLVRKVQKRRLR 2156

  Fly   267 AKG-PSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFN 330
            ||. ..:..||...:|....:.|:|..:.:.|.:      :|::.....|.         |:
  Fly  2157 AKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFS------TTLSDADIALL---------PQ--- 2203

  Fly   331 RRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY-----NDCQEVLVKTVAQHASQLQVNLLLQESM 390
                   :...:::|...:..|.||.:|.|..     .:.|.|.:|::.:.||:...  ||||:.
  Fly  2204 -------INWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAE--LLQEAQ 2259

  Fly   391 MLYEASHPNVLSVLGISIEDYATPFVL-YAATGSVRNLKSFL--------QDPSYARSVTTIQTV 446
            ::....|.|::.::||..:..:...:: :...|   :|.|:|        |:|.....::..:.:
  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAG---DLLSYLRAARATSTQEPQPTAGLSLSELL 2321

  Fly   447 LMGSQLAMAMEHLHNHGVIHKDIAARNCVI-------DDQLRVKLTDSALSRDLFPGD-YNSLGD 503
            .|...:|....:|.:...:|:|:|.|||::       |.:..||:.|..|:||::..| |...|:
  Fly  2322 AMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGE 2386

  Fly   504 GEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPF 568
            | ..|::|:|.|:|....:...||||:||||.||:.|||:.|||..:.:|:..::|:|.||.||.
  Fly  2387 G-LLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPP 2450

  Fly   569 NCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITR 608
            .|.::|::::..||.:.|.|||||.:....|....|.:.|
  Fly  2451 MCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRR 2490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	30/188 (16%)
		PTK_Ryk	336..606	CDD:270639	85/291 (29%)
		Pkinase_Tyr	343..599	CDD:285015	83/277 (30%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	2/6 (33%)
		FN3	1993..2111	CDD:238020	22/131 (17%)
		Pkinase_Tyr	2209..2481	CDD:285015	83/277 (30%)
		PTKc_c-ros	2213..2483	CDD:270640	83/275 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940