Protein Alignment drl and Fgfr2

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_036844.1
• Gene: Fgfr2 / 25022
• RGDID: 2611
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 156/596 - (26%)
• Similarity: 249/596 - (41%)
• Gaps: 146/596 - (24%)

  Fly   102 RIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLRE-EQDSAHE 165
            |||...|..|.|.:.:                |.::.....|.|         ||.| |..|.:.
  Rat   222 RIGGYKVRNQHWSLIM----------------ESVVPSDKGNYT---------CLVENEYGSINH 261

  Fly   166 EYDDDDLD------LLQTARKGH-----GGDIHYVDR--ND--------EHVVANGHQAPEKQRP 209
            .|..|.::      :||.....:     |||:.:|.:  :|        :||..||.:......|
  Rat   262 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLP 326

  Fly   210 V---------------------VTESPVGR---------GNSGGS------KRDFDPMLRENLVP 238
            .                     |||...|.         |.:..|      .:...| :||..:.
  Rat   327 YLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAP-VREKEIT 390

  Fly   239 PASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHP----SNGVH-LIKTSSFQRLPTISSTAH 298
            .:...:.:.:..|...::...::.:.:|....:.:.|    ...|| |.|....:|..|:|:.:.
  Rat   391 ASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESS 455

  Fly   299 NSIYVCPSTITPTYATLTR-------PF----REYE--HEPE-EFNRRLQELTVQKCRVRLSCLV 349
            :|:    ::.||.....||       |.    .|||  .:|: ||.|  .:||:.|       .:
  Rat   456 SSM----NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPR--DKLTLGK-------PL 507

  Fly   350 QEGNFGRIY--------RGTYNDCQEVLVKTVAQHASQLQVNLLLQE-SMMLYEASHPNVLSVLG 405
            .||.||::.        :....:...|.||.:...|::..::.|:.| .||.....|.|::::||
  Rat   508 GEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLG 572

  Fly   406 ISIED---YATPFVLYAATGSVRNLKSFLQ-------DPSY------ARSVTTIQTVLMGSQLAM 454
            ...:|   |.  .|.||:.|   ||:.:|:       :.||      ...:|....|....|||.
  Rat   573 ACTQDGPLYV--IVEYASKG---NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 632

  Fly   455 AMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQK 519
            .||:|.:...||:|:||||.::.:...:|:.|..|:||:...||.........|:||::.|||..
  Rat   633 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD 697

  Fly   520 SHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWAS 584
            ..|...||||||||||||:.|||..||..|...|:...||:|:|:.:|.||.:||:.:|..||.:
  Rat   698 RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHA 762

  Fly   585 MPAERPSFSQL 595
            :|::||:|.||
  Rat   763 VPSQRPTFKQL 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	10/54 (19%)
		PTK_Ryk	336..606	CDD:270639	96/285 (34%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:472250
		Ig strand B	77..81	CDD:409362
		Ig strand C	88..92	CDD:409362
		Ig strand E	109..113	CDD:409362
		Ig strand F	123..128	CDD:409362
		Ig strand G	136..139	CDD:409362
		IgI_2_FGFR	173..267	CDD:409443	15/69 (22%)
		Ig strand A	173..176	CDD:409443
		Ig strand A'	184..189	CDD:409443
		Ig strand B	193..201	CDD:409443
		Ig strand C	207..212	CDD:409443
		Ig strand C'	215..217	CDD:409443
		Ig strand D	226..229	CDD:409443	0/2 (0%)
		Ig strand E	233..238	CDD:409443	1/20 (5%)
		Ig strand F	247..254	CDD:409443	4/15 (27%)
		Ig strand G	257..267	CDD:409443	2/9 (22%)
		Ig	275..377	CDD:472250	18/101 (18%)
		Ig strand B	293..297	CDD:409353	0/3 (0%)
		Ig strand C	306..310	CDD:409353	0/3 (0%)
		Ig strand E	342..346	CDD:409353	0/3 (0%)
		Ig strand F	356..361	CDD:409353	0/4 (0%)
		Ig strand G	369..372	CDD:409353	0/2 (0%)
		PTKc_FGFR2	476..788	CDD:270679	104/312 (33%)