DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and Erbb2

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_058699.2	Gene:	Erbb2 / 24337	RGDID:	2561	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	108/389 - (27%)
Similarity:	171/389 - (43%)	Gaps:	77/389 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ENLVPPASGLVTLIVGGILALVLVSTL-ILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTA 297
            |....|.:.::..:||.:|.|:||..: |||        ||....    |:..:.:||...:...
  Rat   649 EQRASPVTFIIATVVGVLLFLILVVVVGILI--------KRRRQK----IRKYTMRRLLQETELV 701

  Fly   298 HNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY 362
            ..   :.||...|..|.:               |.|:|..::|.:|     :..|.||.:|:|.:
  Rat   702 EP---LTPSGAMPNQAQM---------------RILKETELRKVKV-----LGSGAFGTVYKGIW 743

  Fly   363 -----NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFVLYA 419
                 |....|.:|.:.::.|......:|.|:.::.....|.|..:|||   |.....|..:.|.
  Rat   744 IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYG 808

  Fly   420 A-TGSVRNLKSFLQDPSYARSVTTIQTVLMGS--------QLAMAMEHLHNHGVIHKDIAARNCV 475
            . ...||..:..|                 ||        |:|..|.:|.:..::|:|:||||.:
  Rat   809 CLLDHVREHRGRL-----------------GSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVL 856

  Fly   476 IDDQLRVKLTDSALSR--DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEM 538
            :.....||:||..|:|  |:...:|::  ||...||||::||::.:..:...|||||:||.:||:
  Rat   857 VKSPNHVKITDFGLARLLDIDETEYHA--DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL 919

  Fly   539 CTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF 602
            .|.|..||..|...|:...|:.|.||.||..|..:::.||..||......||.|.:|   :|||
  Rat   920 MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFREL---VSEF 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	85/286 (30%)
		Pkinase_Tyr	343..599	CDD:285015	81/274 (30%)
Erbb2	NP_058699.2	Recep_L_domain	55..177	CDD:279382
		Furin-like	193..342	CDD:279142
		FU	239..284	CDD:238021
		Recep_L_domain	370..490	CDD:279382
		GF_recep_IV	514..647	CDD:291509
		FU	515..565	CDD:238021
		FU	561..607	CDD:214589
		TM_ErbB2	645..688	CDD:213055	14/50 (28%)
		PTKc_HER2	716..994	CDD:270684	88/307 (29%)
		Pkinase_Tyr	724..980	CDD:285015	83/282 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900